Diagnosis of depressive symptoms is critical in wellness programs. This study determined the extent to which Female Sex Workers (FSWs) registered inselected areas in Ilocos Sur, Philippines, experienced depressive symptoms andhow their socio-demographic, medical profile, and self-esteem relate with it. Itutilized the descriptive-correlational method of research, with a Personal DataSheet, the Rosenberg Self-Esteem Scale and the Center for Epidemiologic StudiesDepression Scale (CES-D) as tools for data gathering. The data were statisticallytreated with frequency, percentage, mean and simple correlational analysis.Findings reveal that the majority of the respondents are single; have no children;earn Php10,000/USD 232 and below per month; are already working as FSWs for 1-5 years, 7 days a week and 7-9 hours daily; were employed locally beforeworking as FSWs, drink alcohol and undergo the required medical/laboratoryexaminations regularly. Further, most are 16-20 years old, from the NationalCapital Region, and finished high school education. Their level of self-esteem isaverage, and depressive symptoms, mild to moderate. The socio-demographic andmedical profile is not significantly related with the level of depressive symptoms.Self-esteem is inversely related to the level of depressive symptoms. The lower the level of self-esteem, the higher is the level of depressive symptoms and vice versa.Keywords: Social Sciences, depressive symptoms, descriptive-correlational design,Philippines