The Role of Free Radical Oxidation in the Development of Experimental Urate Nephropathy

2017 ◽  
Vol 163 (1) ◽  
pp. 28-30
Author(s):  
V. Yu. Perfil’ev ◽  
Ya. F. Zverev ◽  
A. Yu. Zharikov ◽  
V. M. Bryukhanov
Keyword(s):  
Free Radical ◽  
Free Radical Oxidation ◽  
Radical Oxidation ◽  
Urate Nephropathy

Clinical and pathogenetic role of state of prooxidant-antioxidant regulation in patients with purulent meningitis in the dynamics of disease

2014 ◽  
Vol 18 (4 (72)) ◽  
Author(s):  
D. A. Zadyraka ◽  
E. V. Riabokon
Keyword(s):  
Free Radical ◽  
Conventional Treatment ◽  
Free Radical Oxidation ◽  
Oxidative Modification ◽  
Blood Proteins ◽  
Radical Oxidation ◽  
Pathogenetic Role ◽  
Purulent Meningitis ◽  
Laboratory Changes

The paper shows, that patients with purulent meningitis on the background of severe clinical and laboratory changes had a disturbance of prooxidant-antioxidant regulation with a shift towards activation of free radical oxidation. In the dynamics of the disease, after 7-10 days of conventional treatment, against the background of a reduction of cephalic and meningeal syndromes intensity, a normalization of liquor and hemogram indices, in most patients there was a further decrease in catalase activity and an increase of nitrites, of parameters of spontaneous and induced oxidative modification of blood proteins that remained when the patients were discharged, compared with healthy people.

scholarly journals Chemiluminescence Studies of Lipoperoxidation Processes in Arterial Hypertension and Stress

2019 ◽  
Vol 4 (1) ◽  
pp. 133-137
Author(s):  
Anastasiya S. Brichagina ◽  
Mariya I. Dolgikh ◽  
Larisa R. Kolesnikova ◽  
Larisa V. Natyaganova
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Free Radical Oxidation ◽  
The State ◽  
Male Rats ◽  
Antioxidant Protection ◽  
Radical Oxidation ◽  
Biochemical Methods ◽  
Peroxidation Processes

Various pathologies, in particular hypertension, accompany violation of the processes of free radical oxidation. The state of the system lipid peroxidation – antioxidant protection can be assessed only by a complex of biochemical methods. The chemiluminescent method is used to obtain a faster result. The method has a number of advantages: measurement of chemiluminescence parameters is carried out in natural conditions and does not require sample preparation, is highly selective, it can be used to identify the presence of free radical pathology, analysis of the intensity of lipid peroxidation processes, the effectiveness of treatment with antioxidant medicament. The aim of the research was to study the lipid peroxidation under hypertension and stress by chemiluminescence. The experiment was conducted on male rats of the ISIAH line. The experiment consisted of 2 stages: stage of alarm and stage of chronic stress. We found that, depending on the type of stress, the state of the system lipid peroxidation-antioxidant protection differed. The role of stress in violation of the processes of lipoperoxidation in hypertension was established. The efficacy of the chemiluminescence method as an alternative to a complex of biochemical methods is shown. Express assessment of pro- and antioxidant status is possible for patients with hypertension.

scholarly journals Specific features of biological oxidation processes in helminthiases of horses

2020 ◽  
Vol 61 (3) ◽  
pp. 126-130
Author(s):  
Larisa V. Pilip ◽  
◽  
Olga V. Byakova ◽  
Maria E. Kazakova ◽  
◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Free Radical ◽  
Free Radical Oxidation ◽  
The Body ◽  
Luminous Intensity ◽  
Radical Oxidation ◽  
Pathological Conditions ◽  
Oxidized Products

The chemical processes occurring in the animal body under pathological conditions are of interest to researchers. The objective of the research was to study the indicators of lipid peroxidation and antioxidant activity in horses infested with helminthiases and treated with anthelmintic paste with an antioxidant. The study has proved the role of parasitic infestation in accelerating the processes of free radical oxidation, which is manifested by a decrease in the light sum of radicals (36.62-39.21), the maximum luminous intensity (6.13-6.98) and antioxidant activity (5.65-6.2) at the start of the research. Chronic invasion increases the concentration of under-oxidized products up to 38.59, and the rate of initiating free radical oxidation – up to 6.95, the values of antioxidant activity being stably low (5.51-5.91). An important role in the regulation of lipid peroxidation in horses during helminthiases, as well as in the process of deworming, is played by the antioxidants contained in anthelmintic preparations. The antioxidant santohin included as a compound in the «Alezan» preparation suppresses enhanced peroxidation and activates the antioxidant protection of the body, which is reflected in a decrease in the light sum of the radicals to as low as 26.73, a maximum luminous intensity to – 3.76, and an increase in antioxidant activity – up to 7.16.

scholarly journals The role of free radical oxidation and inflammation in the development of post-pericardiotomy syndrome after coronary heart disease artery bypass grafting

2017 ◽  
Vol 94 (11) ◽  
pp. 827-831
Author(s):  
V. V. Vnukov ◽  
Roman V. Sidorov ◽  
N. P. Milyutina ◽  
A. A. Ananyan ◽  
D. Yu. Pospelov ◽  
...  
Keyword(s):  
Free Radical ◽  
Antioxidant System ◽  
Artery Bypass ◽  
Myocardial Revascularization ◽  
Free Radical Oxidation ◽  
Bypass Grafting ◽  
Radical Oxidation ◽  
Artery Bypass Grafting ◽  
Postpericardiotomy Syndrome

The purpose of this research was the clinical biochemical study of the role of the antioxidant system, products of lipid peroxidation and proinflammatory mediators in the mechanisms of development of postpericardiotomy syndrome. 50 patients who underwent coronary-artery bypass grafting were examined. They were divided into two groups: those without postpericardiotomy syndrome (1) and patients with this syndrome (2). The results suggest tension of the antioxidant system, overproduction of proinflammatory interleukin-6 and intensification of free radical oxidation in the patients undergoing direct myocardial revascularization.

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