The Role of Inducible NOS2 Gene Polymorphism in the Development of Essential Arterial Hypertension

2019 ◽  
Vol 168 (1) ◽  
pp. 79-83
Author(s):  
L. V. Topchieva ◽  
O.V. Balan ◽  
V. A. Korneeva ◽  
I. E. Malysheva
Keyword(s):  
Gene Polymorphism ◽  
Arterial Hypertension ◽  
Essential Arterial Hypertension

Isolated Peripheral Hypoglossal Nerve Palsy Associated with Arterial Hypertension Caused by Neurovascular Compression

1997 ◽  
Vol 10 (3) ◽  
pp. 369-372 ◽  
Author(s):  
S. Giuffrida ◽  
S. De Luca ◽  
L. Tomarchio ◽  
P. Milone ◽  
D. Restivo ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Nerve Palsy ◽  
Hypoglossal Nerve ◽  
Similar Case ◽  
Left Vertebral Artery ◽  
Neurovascular Compression ◽  
Hypoglossal Nerve Palsy ◽  
Essential Arterial Hypertension ◽  
The Brain

We report a case of isolated left peripheral hypoglossal nerve palsy caused by neurovascular compression associated with essential arterial hypertension. MR and MR-angiography revealed an anomalous course of the left vertebral artery and left PICA. A similar case, without arterial hypertension, was reported by Rollnik et Al. According to Jannetta's hypothesis neurovascular compression of the brain stem may cause essential arterial hypertension. To our knowledge no other similar case of peripheral hypoglossal palsy and arterial hypertension caused by neurovascular compression has been reported. The possible role of neurovascular compression in the pathogenesis of essential hypertension is briefly discussed.

scholarly journals Association between arterial hypertension and chronic obstructive pulmonary disease: role of AGT gene polymorphism

Pneumologia ◽  
2020 ◽  
Vol 68 (4) ◽  
pp. 174-182
Author(s):  
Mariya Marushchak ◽  
Khrystyna Maksiv ◽  
Inna Krynytska ◽  
Kateryna Kozak
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Gene Polymorphism ◽  
Arterial Hypertension ◽  
Pulmonary Disease ◽  
Polymerase Chain Reaction Amplification ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Agt Gene

AbstractBackgroundChronic obstructive pulmonary disease (COPD) continues to cause a heavy health and economic burden in the Europe and around the world. Arterial hypertension (AH) is considered as one of the principal COPD-associated comorbidi-ties. However, no data for association between gene polymorphism and AH in patients with COPD in Ukraine have ever been internationally published. We assessed the genotype and allele frequencies of angiotensinogen (AGT) M235T polymorphisms in patients with COPD and comorbid AH.MethodsThe study group consisted of 96 patients: Group 1 (25 individuals with COPD), Group 2 (23 individuals with AH) and Group 3 (28 individuals with COPD and AH). The control group consisted of 20 healthy subjects. M/T genotypes of AGT were determined by polymerase chain reaction amplification.ResultsThe results of the study have not demonstrated any significant impact of alleles of AGT genes on the occurrence of diseases such as COPD, AH and combinations thereof. However, analysis of odds ratio has demonstrated the presence of a trend towards a protective role of the M allele of the AGT gene concerning occurrence of COPD, AH and their combinations. At the same time, the presence of the T allele of the AGT gene may increase the risk for occurrence of the above-mentioned diseases.ConclusionsThe study that we have conducted suggests that the presence of T allele of the AGT gene at position 235 of the peptide chain both in homozygous and heterozygous states may increase the risk for AH in patients with COPD.

scholarly journals Treatment of arterial hypertension in prognosis of acute myocardial ishemia. Clinical and genetic analysis

2006 ◽  
Vol 12 (3) ◽  
pp. 222-226 ◽  
Author(s):  
R. T. Saygitov ◽  
M. G. Glezer ◽  
D. P. Sementsov ◽  
I. V. Kostomarova ◽  
IN. A. Malygina
Keyword(s):  
Myocardial Infarction ◽  
Genetic Analysis ◽  
Gene Polymorphism ◽  
Arterial Hypertension ◽  
Ace Gene ◽  
Ace Gene Polymorphism ◽  
Genotypic Group

The aim of the study was to evaluated the role of ID ACE gene polymorphism in the development of acute myocardial ishemia in patients with arterial hypertension (HT). Patients with DD genotype were demonstrated a higher risk of myocardial infarction then patients with ID and II genotype. Conversely, the course of HT in II genotypic group is more favorable, but the efficacy of their treatment by traditional agents is minimal.

scholarly journals THE ROLE OF GENES COMBINATION IN ESSENTIAL ARTERIAL HYPERTENSION

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e157
Author(s):  
Yuliia Repchuk ◽  
Larisa Sydorchuk ◽  
Semen Biletsky ◽  
Oksana Petrynych ◽  
Marianna Semianiv ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Essential Arterial Hypertension

THE α2А-ADRENORECEPTOR GENE AND PERSONALITY CHARACTERISTICS IN ADOLESCENTS WITH ESSENTIAL ARTERIAL HYPERTENSION

2017 ◽  
Vol 96 (3) ◽  
pp. 34-39 ◽  
Author(s):  
A. S. Kosovtseva ◽  
◽  
L. I. Kolesnikova ◽  
L. V. Rychkova ◽  
V. M. Polyakov ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Personality Characteristics ◽  
Essential Arterial Hypertension

Role of genetic factors in the development of hypertension in young patients with metabolic syndrome

2020 ◽  
pp. 23-32
Author(s):  
Elena Korneeva ◽  
Mikhail Voevoda ◽  
Sergey Semaev ◽  
Vladimir Maksimov
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Arterial Hypertension ◽  
Genetic Factors ◽  
Young Patients ◽  
Integrin Αiibβ3 ◽  
Ace Gene ◽  
The Metabolic Syndrome

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

Navigating the Road to Transplant in Pulmonary Arterial Hypertension: A Road Less Taken

2016 ◽  
Vol 15 (1) ◽  
pp. 12-13
Author(s):  
Adaani E. Frost ◽  
Harrison W. Farber
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Lung Transplantation ◽  
Small Cell ◽  
Small Cell Lung ◽  
Donor Organ ◽  
The Road ◽  
Lung Allocation Score ◽  
Pulmonary Arterial

Dramatic advances in therapy for pulmonary arterial hypertension (PAH) in the last 20 years have improved survival from a median of 2.5 years in the pretreatment era to 7.5 years currently. However, impressive as that may seem, it is important to note that a median survival of 7.5 years is equivalent to that of surgically resected non-small cell lung cancer, thus underscoring the importance of lung transplantation as a treatment option in patients with PAH. In this edition of Advances, Edelman has reviewed the pathway to transplantation for patients with PAH, detailing the recommendations for timing of referral, listing for lung transplantation, the role of the lung allocation score in allocating a donor organ, and the outcome of lung transplantation.

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