Plasma copper/zinc ratio: an inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population

Abstract Context The evidence of whether hypothyroidism increases mortality in the elderly population is currently inconsistent and conflicting. Objective The objective of this meta-analysis is to determine the impact of hypothyroidism on mortality in the elderly population. Data Sources PubMed, Embase, Cochrane Library, Scopus, and Web of Science databases were searched from inception until May 10, 2019. Study Selection Studies evaluating the association between hypothyroidism and all-cause and/or cardiovascular mortality in the elderly population (ages ≥ 60 years) were eligible. Data Extraction Two reviewers independently extracted data and assessed the quality of the studies. Relative risk (RR) was retrieved for synthesis. A random-effects model for meta-analyses was used. Data Synthesis A total of 27 cohort studies with 1 114 638 participants met the inclusion criteria. Overall, patients with hypothyroidism experienced a higher risk of all-cause mortality than those with euthyroidism (pooled RR = 1.26, 95% CI: 1.15-1.37); meanwhile, no significant difference in cardiovascular mortality was found between patients with hypothyroidism and those with euthyroidism (pooled RR = 1.10, 95% CI: 0.84-1.43). Subgroup analyses revealed that overt hypothyroidism (pooled RR = 1.10, 95% CI: 1.01-1.20) rather than subclinical hypothyroidism (pooled RR = 1.14, 95% CI: 0.92-1.41) was associated with increased all-cause mortality. The heterogeneity primarily originated from different study designs (prospective and retrospective) and geographic locations (Europe, North America, Asia, and Oceania). Conclusions Based on the current evidence, hypothyroidism is significantly associated with increased all-cause mortality instead of cardiovascular mortality among the elderly. We observed considerable heterogeneity, so caution is needed when interpreting the results. Further prospective, large-scale, high-quality studies are warranted to confirm these findings.

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Effect of gestational age on cord blood plasma copper, zinc, magnesium and albumin

Early Human Development ◽

10.1016/s0378-3782(02)00024-5 ◽

2002 ◽

Vol 69 (1-2) ◽

pp. 15-23 ◽

Cited By ~ 24

Author(s):

Shahana Perveen ◽

Waseem Altaf ◽

Nidhi Vohra ◽

Maria Lourdes Bautista ◽

Rita G Harper ◽

...

Keyword(s):

Blood Plasma ◽

Cord Blood ◽

Gestational Age ◽

Plasma Copper ◽

Copper Zinc

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Copper, zinc, magnesium, and calcium in plasma and cerebrospinal fluid of patients with neurological diseases.

Clinical Chemistry ◽

10.1093/clinchem/23.3.485 ◽

1977 ◽

Vol 23 (3) ◽

pp. 485-489 ◽

Cited By ~ 25

Author(s):

J D Bogden ◽

R A Troiano ◽

M M Joselow

Keyword(s):

Cerebrospinal Fluid ◽

Neurological Diseases ◽

Correlation Coefficients ◽

Atomic Absorption Spectrophotometry ◽

The Other ◽

Plasma Zinc ◽

Or Management ◽

Absorption Spectrophotometry ◽

Plasma Copper ◽

Copper Zinc

Abstract We investigated whether information on concentrations of some trace-mental concentrations in blood plasma or cerebrospinal fluid, or both, could be of value in diagnosis or management of various neurological diseases, and whether concentrations in plasma could serve as a means of estimating the protein or metal concentrations in cerebropsinal fluid. Samples of both from 82 patients were analyzed for copper, zinc, magnesium, and calcium by atomic absorption spectrophotometry. Protein concentrations in cerebrospinal fluid were also determined. Metal and protein concentrations in plasma and in cerebrospinal fluid were not strongly enough correlated to permit the estimation of one from the other. However, the correlation coefficients between calcium in plasma and cerebrospinal fluid (r = 0.41), magnesium and protein in cerebrospinal fluid (r = 0.40), magnesium in plasma and calcium in cerebrospinal fluid (r = 0.36), and magnesium and calcium in cerebrospinal fluid (r = 0.66) were statistically significant (P less than .01). Patients with cerebral infarctions had abnormally high copper concentrations in their plasma and cerebrospinal fluid. The ratio of plasma copper to plasma zinc was also significantly higher in cases of cerebral infarction.

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Plasma calcium, copper, magnesium, and zinc concentrations in patients with the alcohol withdrawal syndrome.

Clinical Chemistry ◽

10.1093/clinchem/24.9.1553 ◽

1978 ◽

Vol 24 (9) ◽

pp. 1553-1556 ◽

Cited By ~ 24

Author(s):

J D Bogden ◽

R A Troiano

Keyword(s):

Alcohol Withdrawal ◽

Delirium Tremens ◽

Alcohol Withdrawal Syndrome ◽

Atomic Absorption Spectrophotometry ◽

Underlying Disease ◽

Plasma Copper ◽

Metabolic Imbalance ◽

Zinc Concentrations ◽

Copper Zinc

Abstract We determined zinc, copper, magnesium, and calcium concentrations by atomic absorption spectrophotometry in the plasma of 30 patients hospitalized for treatment of seizures during a period of alcohol withdrawal. Those patients who developed delirium tremens or a prolonged hallucinatory state had significantly higher plasma copper concentrations (P = 0.026), significantly lower zinc concentrations (P = 0.004), and significantly higher copper/zinc ratios (P = 0.001) than the patients who recovered uneventfully. Zinc deficiency may be one of the factors that contribute to the neurologic complications of alcoholism. A determination of the plasma copper/zinc ratio early in the course of alcohol withdrawal could be of value in indicating which patients have the most substantial underlying disease or metabolic imbalance and therefore may be at greatest risk of developing delirium tremens or prolonged hallucinosis.

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