Higher Gait Variability is Associated with Decreased Parietal Gray Matter Volume Among Healthy Older Adults

2013 ◽  
Vol 27 (2) ◽  
pp. 293-295 ◽  
Author(s):  
Olivier Beauchet ◽  
Cédric Annweiler ◽  
Sébastien Celle ◽  
Robert Bartha ◽  
Jean-Claude Barthélémy ◽  
...  
Keyword(s):  
Older Adults ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Gait Variability ◽  
Healthy Older Adults ◽  
Matter Volume

Differential age-dependent associations of gray matter volume and white matter integrity with processing speed in healthy older adults

NeuroImage ◽  
2015 ◽  
Vol 123 ◽  
pp. 42-50 ◽  
Author(s):  
Zhaoping Hong ◽  
Kwun Kei Ng ◽  
Sam K.Y. Sim ◽  
Mei Yi Ngeow ◽  
Hui Zheng ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Gray Matter ◽  
Processing Speed ◽  
Gray Matter Volume ◽  
White Matter Integrity ◽  
Healthy Older Adults ◽  
Matter Volume ◽  
Age Dependent

scholarly journals Leukoaraiosis and Gray Matter Volume Alteration in Older Adults: The PROOF Study

2022 ◽  
Vol 15 ◽  
Author(s):  
Sébastien Celle ◽  
Claire Boutet ◽  
Cédric Annweiler ◽  
Romain Ceresetti ◽  
Vincent Pichot ◽  
...  
Keyword(s):  
Older Adults ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Parahippocampal Gyrus ◽  
Middle Temporal Gyrus ◽  
Healthy Older Adults ◽  
Matter Volume ◽  
Fazekas Scale ◽  
The Right ◽  
The Relationship

Background and Purpose: Leukoaraiosis, also called white matter hyperintensities (WMH), is frequently encountered in the brain of older adults. During aging, gray matter structure is also highly affected. WMH or gray matter defects are commonly associated with a higher prevalence of mild cognitive impairment. However, little is known about the relationship between WMH and gray matter. Our aim was thus to explore the relationship between leukoaraiosis severity and gray matter volume in a cohort of healthy older adults.Methods: Leukoaraiosis was rated in participants from the PROOF cohort using the Fazekas scale. Voxel-based morphometry was performed on brain scans to examine the potential link between WMH and changes of local brain volume. A neuropsychological evaluation including attentional, executive, and memory tests was also performed to explore cognition.Results: Out of 315 75-year-old subjects, 228 had punctuate foci of leukoaraiosis and 62 had begun the confluence of foci. Leukoaraiosis was associated with a decrease of gray matter in the middle temporal gyrus, in the right medial frontal gyrus, and in the left parahippocampal gyrus. It was also associated with decreased performances in memory recall, executive functioning, and depression.Conclusion: In a population of healthy older adults, leukoaraiosis was associated with gray matter defects and reduced cognitive performance. Controlling vascular risk factors and detecting early cerebrovascular disease may prevent, at least in part, dementia onset and progression.

scholarly journals A Metabolic Obesity Profile Is Associated With Decreased Gray Matter Volume in Cognitively Healthy Older Adults

2019 ◽  
Vol 11 ◽  
Author(s):  
Frauke Beyer ◽  
Shahrzad Kharabian Masouleh ◽  
Jürgen Kratzsch ◽  
Matthias L. Schroeter ◽  
Susanne Röhr ◽  
...  
Keyword(s):  
Older Adults ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Healthy Older Adults ◽  
Matter Volume

scholarly journals Voxel-based correlation of 18F-THK5351 accumulation and gray matter volume in the brain of cognitively normal older adults

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yoko Shigemoto ◽  
Daichi Sone ◽  
Miho Ota ◽  
Norihide Maikusa ◽  
Masayo Ogawa ◽  
...  
Keyword(s):  
Older Adults ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Cognitively Normal ◽  
Matter Volume ◽  
The Brain

scholarly journals Alterations of frontal-temporal gray matter volume associate with clinical measures of older adults with COVID-19

2021 ◽  
pp. 100326
Author(s):  
Kuaikuai Duan ◽  
Enrico Premi ◽  
Andrea Pilotto ◽  
Viviana Cristillo ◽  
Alberto Benussi ◽  
...  
Keyword(s):  
Older Adults ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Clinical Measures

scholarly journals Gray Matter Volume Covariance Networks, Social Support, and Cognition in Older Adults

2019 ◽  
Vol 75 (6) ◽  
pp. 1219-1229 ◽  
Author(s):  
Kelly Cotton ◽  
Joe Verghese ◽  
Helena M Blumen
Keyword(s):  
Social Support ◽  
Older Adults ◽  
Executive Function ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Neural Substrates ◽  
Functional Health ◽  
Matter Volume ◽  
With Memory ◽  
Gray Matter Network

Abstract Objective We examined the neural substrates of social support in older adults. Social support is associated with better outcomes in many facets of aging—including cognitive and functional health—but the underlying neural substrates remain largely unexplored. Methods Voxel-based morphometry and multivariate statistics were used to identify gray matter volume covariance networks associated with social support in 112 older adults without dementia (M age = 74.6 years, 50% female), using the Medical Outcomes Study Social Support Survey. Results A gray matter network associated with overall social support was identified and included prefrontal, hippocampal, amygdala, cingulate, and thalamic regions. A gray matter network specifically associated with tangible social support (e.g., someone to help you if you were confined to bed) was also identified, included prefrontal, hippocampal, cingulate, insular, and thalamic regions, and correlated with memory and executive function. Discussion Gray matter networks associated with overall and tangible social support in this study were composed of regions previously associated with memory, executive function, aging, and dementia. Longitudinal research of the interrelationships between social support, brain structure, and cognition is needed, but strengthening social support may represent a new path toward improving cognition in aging that should be explored.

Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000013215
Author(s):  
Tiing Yee Siow ◽  
Cheng Hong Toh ◽  
Jung-Lung Hsu ◽  
Geng-Hao Liu ◽  
Shwu-Hua Lee ◽  
...  
Keyword(s):  
Older Adults ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Community Dwelling ◽  
Intracranial Volume ◽  
Waste Products ◽  
Glymphatic System ◽  
Matter Volume ◽  
Gray Matter Volumes ◽  
Community Dwelling Older Adults

Background and Objectives:The glymphatic system, which is robustly enabled during some stages of sleep, is a fluid-transport pathway that clears cerebral waste products. Most contemporary knowledge regarding glymphatic system is inferred from rodent experiments and human research is limited. The objective of the research is to explore the associations between human glymphatic function, sleep, neuropsychological performances, and cerebral gray matter volumes.Methods:This cross-sectional study included individuals 60 years or older who had participated in the Integrating Systemic Data of Geriatric Medicine to Explore the Solution for Health Aging study between September 2019 and October 2020. Community-dwelling older adults were enrolled at 2 different sites. Participants with dementia, major depressive disorders, and other major organ system abnormalities were excluded. Sleep profile was accessed using questionnaires and polysomnography. Administered neuropsychological test batteries included Everyday Cognition (ECog) and the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Battery (CERAD-NB). Gray matter volumes were estimated based on magnetic resonance imaging (MRI). Diffusion tensor imaging-analysis along the perivascular space (DTI-ALPS) index was used as the MRI marker of glymphatic function.Results:A total of 84 participants (mean [SD] age, 73.3 [7.1] years, 47 [56.0%] women) were analyzed. Multivariate linear regression model determined that age (unstandardized β, -0.0025 [SE, 0.0001]; P = 0.02), N2 sleep duration (unstandardized β, 0.0002 [SE, 0.0001]; P = 0.04), and the apnea-hypopnea index (unstandardized β, -0.0011 [SE, 0.0005]; P = 0.03) were independently associated with DTI-ALPS. Higher DTI-ALPS was associated with better ECog language scores (unstandardized β, -0.59 [SE, 0.28]; P = 0.04) and better CERAD-NB word-list-learning delayed recall subtest scores (unstandardized β, 6.17 [SE, 2.31]; P = 0.009) after co-varying for age and education. Higher DTI-ALPS was also associated with higher gray matter volume (unstandardized β, 107.00 [SE, 43.65]; P = 0.02) after controlling for age, gender, and total intracranial volume.Discussion:Significant associations were identified between glymphatic function and sleep stressing the importance of sleep for brain health. This study also revealed associations between DTI-ALPS, neuropsychological performances, and cerebral gray matter volumes suggesting the potential of DTI-ALPS as a biomarker for cognitive disorders.

scholarly journals What factors explain racial differences in memory‐related gray matter volume regions of interest among cognitively normal older adults?

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Sara L Godina ◽  
Caterina Rosano ◽  
Peter Gianaros ◽  
Howard J Aizenstein ◽  
Michelle C Carlson ◽  
...  
Keyword(s):  
Older Adults ◽  
Racial Differences ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Regions Of Interest ◽  
Cognitively Normal ◽  
Matter Volume
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