Protein N-glycosylation alteration and glycolysis inhibition both contribute to the antiproliferative action of 2-deoxyglucose in breast cancer cells

2018 ◽  
Vol 171 (3) ◽  
pp. 581-591 ◽  
Author(s):  
Audrey Berthe ◽  
Marie Zaffino ◽  
Claire Muller ◽  
François Foulquier ◽  
Marine Houdou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Antiproliferative Action

Inhibition of 11 beta-hydroxysteroid dehydrogenase activity enhances the antiproliferative effect of glucocorticosteroids on MCF-7 and ZR-75-1 breast cancer cells

1997 ◽  
Vol 155 (1) ◽  
pp. 171-180 ◽  
Author(s):  
S Hundertmark ◽  
H Buhler ◽  
M Rudolf ◽  
HK Weitzel ◽  
V Ragosch
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
In Vitro Study ◽  
Hydroxysteroid Dehydrogenase ◽  
Antiproliferative Effect ◽  
Continuous Exposure ◽  
Antiproliferative Action ◽  
Mcf 7

This in vitro study on MCF-7 and ZR-75-1 breast cancer cells showed that the antiproliferative action of glucocorticosteroids (GCS) on breast cancer cells is weakened by a high oxidative activity of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD; EC 1.1.1.146): both endogenic as well as synthetic GCS (dexamethasone, prednisolone) were metabolised to hormonally inactive 11-dehydro metabolites. This enzymatic shield protected the breast cancer cells from the antiproliferative action of GCS. Continuous exposure of breast cancer cells to GCS resulted in enhanced 11 beta-HSD activity. The intracellular GCS concentration was further reduced by this feedback and thus the antiproliferative effect was additionally weakened. These mechanisms of GCS deactivation could be influenced by inhibiting 11 beta-HSD with the liquorice compound glycyrrhetinic acid (GLY). In MCF-7 and ZR-75-1 cultures the antiproliferative effect of GCS was significantly increased by GLY.

Leptin potentiates antiproliferative action of cAMP elevation via protein kinase A down-regulation in breast cancer cells

2010 ◽  
Vol 225 (3) ◽  
pp. 801-809 ◽  
Author(s):  
Silvio Naviglio ◽  
Davide Di Gesto ◽  
Fausto Illiano ◽  
Emilio Chiosi ◽  
Antonio Giordano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Down Regulation ◽  
Antiproliferative Action ◽  
Camp Elevation ◽  
Kinase A

Antiproliferative action of menadione and 1,25(OH)2D3 on breast cancer cells

2009 ◽  
Vol 113 (3-5) ◽  
pp. 227-232 ◽  
Author(s):  
Ana M. Marchionatti ◽  
Gabriela Picotto ◽  
Carmen J. Narvaez ◽  
JoEllen Welsh ◽  
Nori G. Tolosa de Talamoni
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Antiproliferative Action

Evidence for separate mechanisms of antiproliferative action of indomethacin and prostaglandin on MCF-7 breast cancer cells

Life Sciences ◽  
1995 ◽  
Vol 57 (12) ◽  
pp. 1233-1240 ◽  
Author(s):  
P. Planchon ◽  
N. Veber ◽  
V. Magnien ◽  
G. Prévost ◽  
A.B. Starzec ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Antiproliferative Action ◽  
Mcf 7

scholarly journals Inorganic Phosphate as a Novel Signaling Molecule with Antiproliferative Action in MDA-MB-231 Breast Cancer Cells

2013 ◽  
Vol 2 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Annamaria Spina ◽  
Luigi Sapio ◽  
Antonietta Esposito ◽  
Francesca Di Maiolo ◽  
Luca Sorvillo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Inorganic Phosphate ◽  
Breast Cancer Cells ◽  
Signaling Molecule ◽  
Antiproliferative Action

Prohibitin Is a Novel Target Gene of Vitamin D Involved in Its Antiproliferative Action in Breast Cancer Cells

2006 ◽  
Vol 66 (14) ◽  
pp. 7361-7369 ◽  
Author(s):  
Xinjian Peng ◽  
Rajeshwari Mehta ◽  
Sheng Wang ◽  
Srikumar Chellappan ◽  
Rajendra G. Mehta
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Target Gene ◽  
Antiproliferative Action ◽  
Novel Target

The proliferation of breast cancer cells are inhibited by the human intrabody targeting cyclinD1

2010 ◽  
Vol 34 (8) ◽  
pp. S49-S49
Author(s):  
Lei Wang ◽  
Xun Zhou ◽  
Lihong Zhou ◽  
Yong Chen ◽  
Xun Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells
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