Long-term outcome of patients with triphasic mitral flow with a mid-diastolic L wave: prognostic role of left atrial volume and N-terminal pro-brain natriuretic peptide

Abstract Background Left ventricular (LV) longitudinal dysfunction has been identified in type 2 diabetes mellitus (T2DM) patients with preserved LV ejection fraction (LVEF). However, the impact of T2DM on LV longitudinal function or the association of LV longitudinal function with outcome for dilated cardiomyopathy (DCM) remains unclear. Methods We retrospectively studied 206 patients with non-ischemic DCM, mean age of 59 ± 17 years and LVEF of 31 ± 8% (all < 45%). All patients underwent a standard echocardiographic examination, and LV longitudinal function was assessed in terms of global longitudinal strain (GLS). Long-term outcomes were assessed, with a median follow-up period of 6.2 years, as primary endpoints of death from or hospitalization for deteriorating heart failure. Results GLS of DCM patients with T2DM (n = 55) was significantly lower than that in DCM patients without T2DM (n = 151) in spite of similar conventional LV function (7.0 ± 2.0% vs. 7.8 ± 2.2%, p = 0.03). Kaplan-Meier curves indicated that long-term outcomes for DCM patients without T2DM were better than for those with T2DM (log-rank p = 0.001). Subdividing the two groups into four with by using the median value of GLS (7.9%) showed long-term outcome was worst for DCM patients with T2DM and low GLS. Cox proportional hazards analyses demonstrated an independent association of T2DM, GLS and left atrial volume index with long-term outcome. Moreover, multiple regression analysis for the association of GLS showed that T2DM was the independent determinant parameter for GLS as well as for LVEF and left atrial volume index. Conclusion Management of DCM patients with T2DM may be improved by using GLS guidance.

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The Prognostic Role of Cancer Stem Cell Markers for Long-term Outcome After Resection of Colonic Liver Metastases

Anticancer Research ◽

10.21873/anticanres.12224 ◽

2018 ◽

Vol 38 (1) ◽

Cited By ~ 1

Keyword(s):

Stem Cell ◽

Cancer Stem Cell ◽

Liver Metastases ◽

Stem Cell Markers ◽

Prognostic Role ◽

Term Outcome ◽

Long Term Outcome ◽

Cancer Stem Cell Markers

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The role of fibroblast growth factor-23 in left atrial volume

American Heart Journal ◽

10.1016/j.ahj.2013.02.022 ◽

2013 ◽

Vol 165 (5) ◽

pp. e21 ◽

Cited By ~ 2

Author(s):

Supawat Ratanapo ◽

Wonngarm Kittanamongkolchai ◽

Narat Srivali ◽

Saeed Ahmed ◽

Wisit Cheungpasitporn ◽

...

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Left Atrial ◽

Fibroblast Growth Factor 23 ◽

Left Atrial Volume ◽

Fibroblast Growth ◽

Atrial Volume

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The Role of ECT in Schizophrenia

Australasian Psychiatry ◽

10.1046/j.1440-1665.2002.00500.x ◽

2002 ◽

Vol 10 (4) ◽

pp. 385-388 ◽

Cited By ~ 4

Author(s):

Richard Keuneman ◽

Rajiv Weerasundera ◽

David Castle

Keyword(s):

Acute Onset ◽

Clinical Settings ◽

Limited Data ◽

Term Outcome ◽

Long Term Outcome ◽

Affective Symptoms ◽

Maintenance Ect ◽

The Subject

Objective: To review the place of electroconvulsive therapy (ECT) in the treatment of schizophrenia. Conclusions: ECT is as effective, if not more so, than the antipsychotic drugs in certain clinical settings. It can be rapidly effective in acute episodes. When used alone, antipsychotics have comparable or superior efficacy to ECT alone in the short term. However, ECT possibly confers better long-term outcome. Combination treatment with antipsychotic medications and ECT is superior to either treatment alone, and is safe and effective, notably in medication resistant schizophrenia. Benefits of acute courses of ECT may be short-lived unless maintenance ECT is instituted, although there are limited data on the subject. Clinically, patients with acute onset, shorter episodes are more likely to respond to ECT. Catatonia, preoccupation with delusions and hallucinations, and a relative absence of premorbid schizoid and paranoid personality traits, are other clinical factors less strongly predictive of positive response. The presence of affective symptoms is often thought to be predictive of clinical response. However, there is little research evidence for this. While medications remain the mainstay of treatment in schizophrenia, ECT does have a clear and increasingly recognised role which requires further evaluation.

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