Phosphoproteomic Analysis of Neurotrophin Receptor TrkB Signaling Pathways in Mouse Brain

2006 ◽  
Vol 26 (2) ◽  
pp. 163-175 ◽  
Author(s):  
Artour Semenov ◽  
Gundars Goldsteins ◽  
Eero Castrén
Keyword(s):  
Signaling Pathways ◽  
Mouse Brain ◽  
Neurotrophin Receptor

scholarly journals Pharmacologically Diverse Antidepressants Rapidly Activate Brain-Derived Neurotrophic Factor Receptor TrkB and Induce Phospholipase-Cγ Signaling Pathways in Mouse Brain

2007 ◽  
Vol 32 (10) ◽  
pp. 2152-2162 ◽  
Author(s):  
Tomi Rantamäki ◽  
Panu Hendolin ◽  
Aino Kankaanpää ◽  
Jelena Mijatovic ◽  
Petteri Piepponen ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Mouse Brain ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

Early Induction of Neurotrophin Receptor and miRNA Genes in Mouse Brain after Pentilenetetrazole-Induced Neuronal Activity

2021 ◽  
Vol 86 (10) ◽  
pp. 1326-1341
Author(s):  
Anna A. Shmakova ◽  
Karina D. Rysenkova ◽  
Olga I. Ivashkina ◽  
Anna M. Gruzdeva ◽  
Polina S. Klimovich ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Neuronal Activity ◽  
Neurotrophin Receptor ◽  
Mirna Genes

scholarly journals Identification of biological processes and signaling pathways for the knockout of REV-ERB in mouse brain

2021 ◽  
Author(s):  
Jing Li ◽  
Wei Wang ◽  
Hanming Gu
Keyword(s):  
Signaling Pathways ◽  
Mouse Brain ◽  
Hippo Signaling ◽  
Biological Processes ◽  
Orphan Nuclear Receptor ◽  
Ppi Network ◽  
Illumina Hiseq ◽  
Number Of Genes ◽  
Ppar Signaling ◽  
The Brain

REV-ERB is an orphan nuclear receptor that is widely expressed in the brain and inhibits transcriptional activities. A variety of genes affect the activity and expression of REV-ERB. In this study, our objective is to identify significant signaling pathways and biological processes in the knockout of the REV-ERB mouse brain. The GSE152919 dataset was originally created by using the Illumina HiSeq 4000 (Mus musculus). The KEGG and GO analyses suggested that biological processes "PPAR signaling", "Hippo signaling", and "Hypertrophic cardiomyopathy (HCM)" are mostly affected in the knockout of REV-ERB. Furthermore, we identified a number of genes according to the PPI network including NPAS2, CRY2, BMAL1, and CRY1 which were involved in the lack of REV-ERB in the brain. Therefore, our study provides further insights into the study of circadian clocks.

Sign in / Sign up

Export Citation Format

Share Document