A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer

2005 ◽  
Vol 21 (8) ◽  
pp. 755-764 ◽  
Author(s):  
Yixing Jiang ◽  
Liwei Wang ◽  
Weida Gong ◽  
Daoyan Wei ◽  
Xiangdong Le ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Lymph Node ◽  
Growth Factor ◽  
Lymph Node Metastasis ◽  
Regional Lymph Node ◽  
Human Gastric Cancer ◽  
Factor I ◽  
Node Metastasis ◽  
High Expression Level

scholarly journals miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Yuejuan Xu ◽  
Jue Sun ◽  
Jianhua Xu ◽  
Qi Li ◽  
Yuewu Guo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Malignant Disease ◽  
Close Association ◽  
Survival Rates ◽  
Expression Level ◽  
Human Gastric Cancer ◽  
Node Metastasis ◽  
Kaplan Meier

Background. Gastric cancer (GC) is an important malignant disease around the world. Abnormalities of microRNAs (miRNAs) have been implicated in carcinogenesis of various cancers. In the present study, we examined miR-21 expression in human gastric cancer with lymph node metastasis and attempted to uncover its relationship with clinicopathologic data, especially with lymph node metastasis.Materials and Methods. The expression levels of miR-21 in the tumor specimens of GC patients were quantified by RT-PCR. The correlation between miR-21 level and multiple clinicopathological factors was then examined by Mann-Whitney test, Kaplan-Meier survival analysis, and operating characteristic (ROC) analysis.Results. The expression level of miR-21 was higher in GC patients with lymph node metastasis than in those without lymph node metastasis (P<0.05). Expression level of miR-21 was significantly correlated with histologic type, T stage, lymph node metastasis and pTNM stage. The overall survival rates in GC patients with low upregulated miR-21 expression were significantly higher than those with high upregulated miR-21 (P<0.05).Conclusion. A close association is implicated between the elevated miR-21and lymph node metastasis, which could potentially be exploited as a practical biomarker for lymph node metastasis in patients with GC.

scholarly journals RELATION BETWEEN LYMPH NODE METASTASIS AND NATURAL KILLER CELLS OF REGIONAL LYMPH NODE IN GASTRIC CANCER

1993 ◽  
Vol 54 (9) ◽  
pp. 2229-2234
Author(s):  
Tadahiko OGAWARA ◽  
Takayoshi SEKIKAWA ◽  
Keisuke SAKAI ◽  
Kohji KOHNO ◽  
Yuji HONDA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Natural Killer Cells ◽  
Lymph Node Metastasis ◽  
Natural Killer ◽  
Regional Lymph Node ◽  
Killer Cells ◽  
Node Metastasis
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