Increased expression of phospho-acetyl-CoA carboxylase protein is an independent prognostic factor for human gastric cancer without lymph node metastasis

2014 ◽  
Vol 31 (7) ◽  
Author(s):  
Wenzhang Fang ◽  
Hongmei Cui ◽  
Danyang Yu ◽  
Ying Chen ◽  
Jiejun Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Lymph Node Metastasis ◽  
Independent Prognostic Factor ◽  
Human Gastric Cancer ◽  
Acetyl Coa Carboxylase ◽  
Acetyl Coa ◽  
Node Metastasis

scholarly journals Lymph Node Metastasis, a Unique Independent Prognostic Factor in Early Gastric Cancer

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0129531 ◽  
Author(s):  
Bai-Wei Zhao ◽  
Yong-Ming Chen ◽  
Shan-Shan Jiang ◽  
Yin-Bo chen ◽  
Zhi-Wei Zhou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Independent Prognostic Factor ◽  
Node Metastasis

scholarly journals miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Yuejuan Xu ◽  
Jue Sun ◽  
Jianhua Xu ◽  
Qi Li ◽  
Yuewu Guo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Malignant Disease ◽  
Close Association ◽  
Survival Rates ◽  
Expression Level ◽  
Human Gastric Cancer ◽  
Node Metastasis ◽  
Kaplan Meier

Background. Gastric cancer (GC) is an important malignant disease around the world. Abnormalities of microRNAs (miRNAs) have been implicated in carcinogenesis of various cancers. In the present study, we examined miR-21 expression in human gastric cancer with lymph node metastasis and attempted to uncover its relationship with clinicopathologic data, especially with lymph node metastasis.Materials and Methods. The expression levels of miR-21 in the tumor specimens of GC patients were quantified by RT-PCR. The correlation between miR-21 level and multiple clinicopathological factors was then examined by Mann-Whitney test, Kaplan-Meier survival analysis, and operating characteristic (ROC) analysis.Results. The expression level of miR-21 was higher in GC patients with lymph node metastasis than in those without lymph node metastasis (P<0.05). Expression level of miR-21 was significantly correlated with histologic type, T stage, lymph node metastasis and pTNM stage. The overall survival rates in GC patients with low upregulated miR-21 expression were significantly higher than those with high upregulated miR-21 (P<0.05).Conclusion. A close association is implicated between the elevated miR-21and lymph node metastasis, which could potentially be exploited as a practical biomarker for lymph node metastasis in patients with GC.

Significance of lymph node metastasis in pancreatic neuroendocrine tumors.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 210-210
Author(s):  
Katsunobu Taki ◽  
Daisuke Hashimoto ◽  
Nobuyuki Ozaki ◽  
Shinjiro Tomiyasu ◽  
Risa Inoue ◽  
...  
Keyword(s):  
Lymph Node ◽  
Prognostic Factor ◽  
Lymph Node Metastasis ◽  
Lymph Node Dissection ◽  
Disease Free Survival ◽  
Independent Prognostic Factor ◽  
University Hospital ◽  
Clinicopathological Parameters ◽  
Node Dissection ◽  
Node Metastasis

210 Background: Pancreatic neuroendocrine tumor (PNET) is uncommon, and its prognosis is generally better than that of pancreatic cancer. Although some PNET patients have lymph node metastasis, its effect on their prognosis is unclear, lymph node dissection for PNET is controversial. Our study aimed to clarify the significance of lymph node metastasis in PNET. Methods: We retrospectively examined 83 PNET patients who underwent pancreatic resections at Kumamoto University Hospital, Saiseikai Kumamoto Hospital and Kumamoto Regional Medical Center from April 2001 to December 2014. We excluded NET G3 from them. Their clinicopathological parameters were analyzed by the absence or presence of lymph node metastasis, and with regard to disease-free survival (DFS) and overall survival (OS). Results: Although 5-year DFS was lymph node metastasis group: 73.3%, and no lymph node metastasis group: 85.0% (P = 0.474); and 5-year OS was lymph node metastasis: 91.7% and no lymph node metastasis: 96.2% (P = 0.055), lymph node metastasis was not an independent risk factor for DFS or OS in multivariate analysis. However, tumors larger than 1.8 cm were found to be an independent prognostic factor. Conclusions: Although lymph node metastasis was not an independent prognostic factor, tumors larger than 1.8 cm were an independent prognostic factor, and warrant lymph node dissection for PNET patients with tumors of this size.

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