Metformin Use Is Inversely Associated with Prevalent, but Not Incident Colorectal Adenomas

2022 ◽  
Author(s):  
Anna Krigel ◽  
Snow Trinh T. Nguyen ◽  
Nawar Talukder ◽  
Ching-Ho Huang ◽  
Carlos Buitrago ◽  
...  
Keyword(s):  
Colorectal Adenomas

Old Drug Combo Prevents Colorectal Adenomas

2008 ◽  
Vol 38 (10) ◽  
pp. 37
Author(s):  
BETSY BATES
Keyword(s):  
Colorectal Adenomas

The prognostic value of cell proliferation in colorectal adenomas and carcinomas

2010 ◽  
Vol 48 (05) ◽  
Author(s):  
R Harisi ◽  
G Székely ◽  
B Járay ◽  
T Winternitz ◽  
L Harsányi ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Prognostic Value ◽  
Colorectal Adenomas

Su1424 Colorectal Adenomas and its Relationship to Obesity; A Meta-Analysis

2012 ◽  
Vol 75 (4) ◽  
pp. AB327 ◽  
Author(s):  
Sailajah Janarthanan ◽  
Anna G. Taranova
Keyword(s):  
Meta Analysis ◽  
Colorectal Adenomas

scholarly journals Circulating Biomarkers of Colorectal Cancer (CRC)—Their Utility in Diagnosis and Prognosis

2021 ◽  
Vol 10 (11) ◽  
pp. 2391
Author(s):  
Marta Łukaszewicz-Zając ◽  
Barbara Mroczko
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Mediators ◽  
Colorectal Adenomas ◽  
Global Burden ◽  
Circulating Biomarkers ◽  
Specific Nature ◽  
Diagnosis And Prognosis ◽  
Specific Proteins ◽  
Novel Biomarkers ◽  
Number Of Publications

The global burden of colorectal cancer (CRC) is expected to increase, with 2.2 million new cases and 1.1 million annual deaths by 2030. Therefore, the establishment of novel biomarkers useful in the early diagnosis of CRC is of utmost importance. A number of publications have documented the significance of the overexpression of several specific proteins, such as inflammatory mediators, in CRC progression. However, little is known about the potential utility of these proteins as circulating blood tumor biomarkers of CRC. Therefore, in the present review we report the results of our previous original studies as well as the findings of other authors who investigated whether inflammatory mediators might be used as novel biomarkers in the diagnosis and prognosis of CRC. Our study revealed that among all of the tested proteins, serum M-CSF, CXCL-8, IL-6 and TIMP-1 have the greatest value in the diagnosis and progression of CRC. Serum TIMP-1 is useful in differentiating between CRC and colorectal adenomas, whereas M-CSF and CRP are independent prognostic factors for the survival of patients with CRC. This review confirms the promising significance of these proteins as circulating biomarkers for CRC. However, due to their non-specific nature, further validation of their sensitivity and specificity is required.

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