Endoscopic removal of high-risk colorectal adenomas: safe and effective?

2017 ◽  
Author(s):  
Mariann Rutka
Keyword(s):  
High Risk ◽  
Colorectal Adenomas ◽  
Endoscopic Removal

scholarly journals Proteins in stool as biomarkers for non‐invasive detection of colorectal adenomas with high risk of progression

2020 ◽  
Vol 250 (3) ◽  
pp. 288-298 ◽  
Author(s):  
Malgorzata A Komor ◽  
Linda JW Bosch ◽  
Veerle MH Coupé ◽  
Christian Rausch ◽  
Thang V Pham ◽  
...  
Keyword(s):  
High Risk ◽  
Colorectal Adenomas ◽  
Non Invasive ◽  
Risk Of Progression

Impact of colonoscopy screening on individuals at high risk of hereditary nonpolyposis colorectal cancer (HNPCC).

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 384-384
Author(s):  
C. Guillen-Ponce ◽  
C. Martinez-Sevila ◽  
R. Jover ◽  
R. Perea ◽  
M. Molina-Garrido ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Early Stage ◽  
Colorectal Adenomas ◽  
Medical Documentation ◽  
Synchronous Tumors ◽  
Colonoscopy Screening ◽  
Amsterdam Criteria ◽  
The Impact

384 Background: Colonoscopy screening reduces the incidence of, and mortality from, colorectal cancer (CRC) in individuals with HNPCC. The aim of this study was to determine the impact of colonoscopic follow-up in individuals at high risk of HNPCC, in terms of detection of precursor lesions (adenomas) or cancer. Methods: Between 2005-2008, 163 individuals with HNPCC were advised to undergo regular follow-up colonoscopy. Compliance and results of the scans were evaluated annually and were verified with medical documentation. Results: Of the 125 individuals who underwent at least one colonoscopy during the follow-up period of colonoscopy screening, in 33 subjects (26%) at least one colonic adenoma was detected. The median number of adenomas detected per colonoscopy in individuals with polyps was 2. The number of colonoscopies with polyps did not differ between women and men. However, the number of polyps removed by colonoscopy and the total number of polyps removed during the follow-up period was significantly higher in men (p = 0.005, p = 0.05 bilateral, respectively). 5 individuals (4%) were diagnosed with CRC, one of whom had two synchronous tumors. Of these, four individuals had properly followed the screening recommendations with the recommended frequency. In the case where two synchronous tumors were detected, it was the first colonoscopy screening that had been performed on the individual. None had had cancer previously, they were healthy relatives of an index case. All except one belonged to families that fulfilled the Amsterdam criteria I / II. All the tumors were diagnosed at an early stage, except two, which exhibited positive nodes. Conclusions: Colonoscopy screening is effective in diagnosing colorectal adenomas and cancer in individuals with HNPCC. Men with HNPCC have a greater number of colorectal adenomas. Screening allows the detection of colorectal cancer at an early stages. Funded by a young researcher's grant from the Spanish Society of Medical Oncology 2006. No significant financial relationships to disclose.

Cost-Effectiveness of Surveillance Guidelines for Patients with Low-Risk or High-Risk Colorectal Adenomas

2017 ◽  
Vol 152 (5) ◽  
pp. S535-S536
Author(s):  
Reinier Meester ◽  
Iris Lansdorp-Vogelaar ◽  
Ann G. Zauber ◽  
Michal F. Kaminski ◽  
Oeyvind Holme ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
High Risk ◽  
Low Risk ◽  
Colorectal Adenomas

scholarly journals Gastroenterology visitation and reminders predict surveillance uptake for patients with adenomas with high-risk features

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anthony Myint ◽  
Edgar Corona ◽  
Liu Yang ◽  
Bao Sean Nguyen ◽  
Christina Lin ◽  
...  
Keyword(s):  
High Risk ◽  
Health System ◽  
Population Surveillance ◽  
Colorectal Adenomas ◽  
Screening Colonoscopy ◽  
High Risk Population ◽  
Tubular Adenoma ◽  
Surveillance Colonoscopy ◽  
Potential Health ◽  
Increased Risk

AbstractIndividuals diagnosed with colorectal adenomas with high-risk features during screening colonoscopy have increased risk for the development of subsequent adenomas and colorectal cancer. While US guidelines recommend surveillance colonoscopy at 3 years in this high-risk population, surveillance uptake is suboptimal. To inform future interventions to improve surveillance uptake, we sought to assess surveillance rates and identify facilitators of uptake in a large integrated health system. We utilized a cohort of patients with a diagnosis of ≥ 1 tubular adenoma (TA) with high-risk features (TA ≥ 1 cm, TA with villous features, TA with high-grade dysplasia, or ≥ 3 TA of any size) on colonoscopy between 2013 and 2016. Surveillance colonoscopy completion within 3.5 years of diagnosis of an adenoma with high-risk features was our primary outcome. We evaluated surveillance uptake over time and utilized logistic regression to detect factors associated with completion of surveillance colonoscopy. The final cohort was comprised of 405 patients. 172 (42.5%) patients successfully completed surveillance colonoscopy by 3.5 years. Use of a patient reminder (telephone, electronic message, or letter) for due surveillance (adjusted odds = 1.9; 95%CI = 1.2–2.8) and having ≥ 1 gastroenterology (GI) visit after diagnosis of an adenoma with high-risk features (adjusted odds = 2.6; 95%CI = 1.6–4.2) significantly predicted surveillance colonoscopy completion at 3.5 years. For patients diagnosed with adenomas with high-risk features, surveillance colonoscopy uptake is suboptimal and frequently occurs after the 3-year surveillance recommendation. Patient reminders and visitation with GI after index colonoscopy are associated with timely surveillance completion. Our findings highlight potential health system interventions to increase timely surveillance uptake for patients diagnosed with adenomas with high-risk features.

Mo1620 Chromosomal Aberrations Implicated in Colorectal Adenoma to Carcinoma Progression as Markers of High Risk Colorectal Adenomas

2012 ◽  
Vol 142 (5) ◽  
pp. S-643 ◽  
Author(s):  
Jochim S. Terhaar sive Droste ◽  
Anne S. Bolijn ◽  
Myrthe Burink ◽  
van ◽  
Nicole C. van Grieken ◽  
...  
Keyword(s):  
High Risk ◽  
Colorectal Adenoma ◽  
Chromosomal Aberrations ◽  
Colorectal Adenomas

Increased risk of ‘high-risk’ colorectal adenomas in overweight men

1993 ◽  
Vol 104 (1) ◽  
pp. 137-144 ◽  
Author(s):  
Ekkehard Bayerdörffer ◽  
Gerd Alexander Mannes ◽  
Thomas Ochsenkühn ◽  
Wolfgang Köpcke ◽  
Baldur Wiebecke ◽  
...  
Keyword(s):  
High Risk ◽  
Colorectal Adenomas ◽  
Increased Risk

scholarly journals Untargeted Metabolomics Reveals Major Differences in the Plasma Metabolome between Colorectal Cancer and Colorectal Adenomas

Metabolites ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 119
Author(s):  
Tanja Gumpenberger ◽  
Stefanie Brezina ◽  
Pekka Keski-Rahkonen ◽  
Andreas Baierl ◽  
Nivonirina Robinot ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Molecular Mechanisms ◽  
Low Risk ◽  
Colorectal Adenomas ◽  
Colorectal Carcinogenesis ◽  
Sporadic Colorectal Cancer ◽  
Molecular Features ◽  
Colorectal Cancer Patients

Sporadic colorectal cancer is characterized by a multistep progression from normal epithelium to precancerous low-risk and high-risk adenomas to invasive cancer. Yet, the underlying molecular mechanisms of colorectal carcinogenesis are not completely understood. Within the “Metabolomic profiles throughout the continuum of colorectal cancer” (MetaboCCC) consortium we analyzed data generated by untargeted, mass spectrometry-based metabolomics using plasma from 88 colorectal cancer patients, 200 patients with high-risk adenomas and 200 patients with low-risk adenomas recruited within the “Colorectal Cancer Study of Austria” (CORSA). Univariate logistic regression models comparing colorectal cancer to adenomas resulted in 442 statistically significant molecular features. Metabolites discriminating colorectal cancer patients from those with adenomas in our dataset included acylcarnitines, caffeine, amino acids, glycerophospholipids, fatty acids, bilirubin, bile acids and bacterial metabolites of tryptophan. The data obtained discovers metabolite profiles reflecting metabolic differences between colorectal cancer and colorectal adenomas and delineates a potentially underlying biological interpretation.

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