Cyclodextrin polymers decorated with RGD peptide as delivery systems for targeted anti-cancer chemotherapy

2018 ◽  
Vol 37 (4) ◽  
pp. 771-778 ◽  
Author(s):  
Maurizio Viale ◽  
Rita Tosto ◽  
Valentina Giglio ◽  
Giuseppe Pappalardo ◽  
Valentina Oliveri ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Delivery Systems ◽  
Rgd Peptide ◽  
Anti Cancer ◽  
Cyclodextrin Polymers

Cancer Treatment with Liposomes Based Drugs and Genes Co-delivery Systems

2018 ◽  
Vol 25 (28) ◽  
pp. 3319-3332 ◽  
Author(s):  
Chuanmin Zhang ◽  
Shubiao Zhang ◽  
Defu Zhi ◽  
Jingnan Cui
Keyword(s):  
Cell Cycle ◽  
Cancer Cells ◽  
Synergistic Effects ◽  
Resistance Mechanisms ◽  
Delivery Systems ◽  
Cell Cycle Checkpoints ◽  
Drug Efflux ◽  
Cancer Resistance ◽  
Cancer Models ◽  
Anti Cancer

There are several mechanisms by which cancer cells develop resistance to treatments, including increasing anti-apoptosis, increasing drug efflux, inducing angiogenesis, enhancing DNA repair and altering cell cycle checkpoints. The drugs are hard to reach curative effects due to these resistance mechanisms. It has been suggested that liposomes based co-delivery systems, which can deliver drugs and genes to the same tumor cells and exhibit synergistic anti-cancer effects, could be used to overcome the resistance of cancer cells. As the co-delivery systems could simultaneously block two or more pathways, this might promote the death of cancer cells by sensitizing cells to death stimuli. This article provides a brief review on the liposomes based co-delivery systems to overcome cancer resistance by the synergistic effects of drugs and genes. Particularly, the synergistic effects of combinatorial anticancer drugs and genes in various cancer models employing multifunctional liposomes based co-delivery systems have been discussed. This review also gives new insights into the challenges of liposomes based co-delivery systems in the field of cancer therapy, by which we hope to provide some suggestions on the development of liposomes based co-delivery systems.

Factors Influencing the Immunogenicity and Immunotoxicity of Cyclic RGD Peptide-Modified Nanodrug Delivery Systems

2020 ◽  
Vol 17 (9) ◽  
pp. 3281-3290
Author(s):  
Xiaoyi Wang ◽  
Nana Meng ◽  
Songli Wang ◽  
Linwei Lu ◽  
Huan Wang ◽  
...  
Keyword(s):  
Delivery Systems ◽  
Rgd Peptide ◽  
Nanodrug Delivery ◽  
Factors Influencing

PEG-conjugated triacontanol micelles as docetaxel delivery systems for enhanced anti-cancer efficacy

2019 ◽  
Vol 10 (1) ◽  
pp. 122-135 ◽  
Author(s):  
Xiaoyu Lu ◽  
Min Fang ◽  
Yue Yang ◽  
Yu Dai ◽  
Jiaqiu Xu ◽  
...  
Keyword(s):  
Delivery Systems ◽  
Anti Cancer

scholarly journals Polymeric Co-Delivery Systems in Cancer Treatment: An Overview on Component Drugs’ Dosage Ratio Effect

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1035 ◽  
Author(s):  
Jiayi Pan ◽  
Kobra Rostamizadeh ◽  
Nina Filipczak ◽  
Vladimir Torchilin
Keyword(s):  
Cancer Therapy ◽  
Cancer Treatment ◽  
Therapeutic Agent ◽  
Polymeric Nanoparticles ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Individual Therapy ◽  
Multiple Factors ◽  
Therapeutic Outcomes ◽  
Anti Cancer

Multiple factors are involved in the development of cancers and their effects on survival rate. Many are related to chemo-resistance of tumor cells. Thus, treatment with a single therapeutic agent is often inadequate for successful cancer therapy. Ideally, combination therapy inhibits tumor growth through multiple pathways by enhancing the performance of each individual therapy, often resulting in a synergistic effect. Polymeric nanoparticles prepared from block co-polymers have been a popular platform for co-delivery of combinations of drugs associated with the multiple functional compartments within such nanoparticles. Various polymeric nanoparticles have been applied to achieve enhanced therapeutic efficacy in cancer therapy. However, reported drug ratios used in such systems often vary widely. Thus, the same combination of drugs may result in very different therapeutic outcomes. In this review, we investigated polymeric co-delivery systems used in cancer treatment and the drug combinations used in these systems for synergistic anti-cancer effect. Development of polymeric co-delivery systems for a maximized therapeutic effect requires a deeper understanding of the optimal ratio among therapeutic agents and the natural heterogenicity of tumors.

Clinical factors predicting bacteremia in low-risk febrile neutropenia after anti-cancer chemotherapy

2010 ◽  
Vol 19 (11) ◽  
pp. 1761-1767 ◽  
Author(s):  
Young Eun Ha ◽  
Jae-Hoon Song ◽  
Won Ki Kang ◽  
Kyong Ran Peck ◽  
Doo Ryeon Chung ◽  
...  
Keyword(s):  
Febrile Neutropenia ◽  
Cancer Chemotherapy ◽  
Low Risk ◽  
Clinical Factors ◽  
Anti Cancer
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