Aristolochic acid I: an investigation into the role of food crops contamination, as a potential natural exposure pathway

2021 ◽  
Author(s):  
Lavinia Paula Drăghia ◽  
Alexandra Teodora Lukinich-Gruia ◽  
Camelia Oprean ◽  
Nikola M. Pavlović ◽  
Virgil Păunescu ◽  
...  
Keyword(s):  
Aristolochic Acid ◽  
Food Crops ◽  
Natural Exposure ◽  
Exposure Pathway ◽  
Aristolochic Acid I

scholarly journals Only Hyperuricemia with Crystalluria, but not Asymptomatic Hyperuricemia, Drives Progression of Chronic Kidney Disease

2020 ◽  
Vol 31 (12) ◽  
pp. 2773-2792
Author(s):  
Markus Sellmayr ◽  
Moritz Roman Hernandez Petzsche ◽  
Qiuyue Ma ◽  
Nils Krüger ◽  
Helen Liapis ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Aristolochic Acid ◽  
Interstitial Fibrosis ◽  
Ckd Progression ◽  
Fticr Mass Spectrometry ◽  
Progressive Decline ◽  
Granulomatous Interstitial Nephritis ◽  
Crystal Nephropathy ◽  
Aristolochic Acid I

BackgroundThe roles of asymptomatic hyperuricemia or uric acid (UA) crystals in CKD progression are unknown. Hypotheses to explain links between UA deposition and progression of CKD include that (1) asymptomatic hyperuricemia does not promote CKD progression unless UA crystallizes in the kidney; (2) UA crystal granulomas may form due to pre-existing CKD; and (3) proinflammatory granuloma-related M1-like macrophages may drive UA crystal-induced CKD progression.MethodsMALDI-FTICR mass spectrometry, immunohistochemistry, 3D confocal microscopy, and flow cytometry were used to characterize a novel mouse model of hyperuricemia and chronic UA crystal nephropathy with granulomatous nephritis. Interventional studies probed the role of crystal-induced inflammation and macrophages in the pathology of progressive CKD.ResultsAsymptomatic hyperuricemia alone did not cause CKD or drive the progression of aristolochic acid I-induced CKD. Only hyperuricemia with UA crystalluria due to urinary acidification caused tubular obstruction, inflammation, and interstitial fibrosis. UA crystal granulomas surrounded by proinflammatory M1-like macrophages developed late in this process of chronic UA crystal nephropathy and contributed to the progression of pre-existing CKD. Suppressing M1-like macrophages with adenosine attenuated granulomatous nephritis and the progressive decline in GFR. In contrast, inhibiting the JAK/STAT inflammatory pathway with tofacitinib was not renoprotective.ConclusionsAsymptomatic hyperuricemia does not affect CKD progression unless UA crystallizes in the kidney. UA crystal granulomas develop late in chronic UA crystal nephropathy and contribute to CKD progression because UA crystals trigger M1-like macrophage-related interstitial inflammation and fibrosis. Targeting proinflammatory macrophages, but not JAK/STAT signaling, can attenuate granulomatous interstitial nephritis.

Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity

2013 ◽  
Vol 266 (2) ◽  
pp. 198-203 ◽  
Author(s):  
Zhenzhou Jiang ◽  
Qingli Bao ◽  
Lixin Sun ◽  
Xin Huang ◽  
Tao Wang ◽  
...  
Keyword(s):  
Respiratory Chain ◽  
Aristolochic Acid ◽  
Mtdna Depletion ◽  
Chain Defects ◽  
Respiratory Chain Defects ◽  
Aristolochic Acid I

scholarly journals Traditional Chinese medicine: Pivotal role of the spleen in the metabolism of aristolochic acid I in rats is dependent on oatp2a1

2016 ◽  
Vol 14 (4) ◽  
pp. 3243-3250 ◽  
Author(s):  
Ting Xiang ◽  
Zhangbin Yang ◽  
Baoguo Sun ◽  
Haoxuan Luo ◽  
Shijun Zhang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Aristolochic Acid ◽  
Pivotal Role ◽  
Aristolochic Acid I

Critical Role of Organic Anion Transporters 1 and 3 in Kidney Accumulation and Toxicity of Aristolochic Acid I

2011 ◽  
Vol 8 (6) ◽  
pp. 2183-2192 ◽  
Author(s):  
Xiang Xue ◽  
Li-Kun Gong ◽  
Kazuya Maeda ◽  
Yang Luan ◽  
Xin-Ming Qi ◽  
...  
Keyword(s):  
Aristolochic Acid ◽  
Organic Anion ◽  
Critical Role ◽  
Organic Anion Transporters ◽  
Anion Transporters ◽  
Aristolochic Acid I

The potential role of aquaporin 1 on aristolochic acid I induced epithelial mesenchymal transition on HK-2 cells

2018 ◽  
Vol 233 (6) ◽  
pp. 4919-4925 ◽  
Author(s):  
Ji Li ◽  
Mincheng Zhang ◽  
Yong Mao ◽  
Yimao Li ◽  
Xiaoxia Zhang ◽  
...  
Keyword(s):  
Potential Role ◽  
Aristolochic Acid ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Aquaporin 1 ◽  
Aristolochic Acid I

Role of P450 1A1 and P450 1A2 in Bioactivation versus Detoxication of the Renal Carcinogen Aristolochic Acid I: Studies inCyp1a1(−/−),Cyp1a2(−/−), andCyp1a1/1a2(−/−)Mice

2011 ◽  
Vol 24 (10) ◽  
pp. 1710-1719 ◽  
Author(s):  
Volker M. Arlt ◽  
Kateřina Levová ◽  
František Bárta ◽  
Zhanquan Shi ◽  
James D. Evans ◽  
...  
Keyword(s):  
Aristolochic Acid ◽  
Aristolochic Acid I

scholarly journals Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:Cytochrome P450 Reductase Null (HRN) Mouse Model

2011 ◽  
Vol 121 (1) ◽  
pp. 43-56 ◽  
Author(s):  
Kateřina Levová ◽  
Michaela Moserová ◽  
Věra Kotrbová ◽  
Miroslav Šulc ◽  
Colin J. Henderson ◽  
...  
Keyword(s):  
Mouse Model ◽  
Aristolochic Acid ◽  
Cytochromes P450 ◽  
P450 Reductase ◽  
Nadph:Cytochrome P450 Reductase ◽  
Aristolochic Acid I

Lupane Type Triterpene Isolated from the Leaves of Thecacoris Annobonea (Euphorbiaceae)

2013 ◽  
Vol 12 (10) ◽  
pp. 695-701
Author(s):  
Herve Martial Poumale Poumale ◽  
Alphonsine Nkapwa Guedem ◽  
Louis Pergaud Sandjo ◽  
Bonaventure Tchaleu Ngadjui ◽  
Yoshihito Shiono
Keyword(s):  
Antimicrobial Activity ◽  
Root Growth ◽  
Betulinic Acid ◽  
Aristolochic Acid ◽  
2D Nmr ◽  
Aristolochic Acid I

A new lupane type triterpene (1), together with betulinic acid (2), friedelin (3), aristolochic acid I (4), alpinumisoflavone (5) and 4’-O-methylepinumisoflavone (6) have been isolated from the leaves of Thecacoris annobonea. The structure of the new compound was elucidated on the basis of 1 and 2D NMR experiments. The isolated compounds were evaluated for their phytotoxicity and antimicrobial activity. 1 exhibited significant antimicrobial activity at 30 μg/ml and compounds 1, 2, 3, 4, 5 and 6 inhibited root growth lettuce at 100 μg/ml. 

Sign in / Sign up

Export Citation Format

Share Document