The potential role of aquaporin 1 on aristolochic acid I induced epithelial mesenchymal transition on HK-2 cells

2018 ◽  
Vol 233 (6) ◽  
pp. 4919-4925 ◽  
Author(s):  
Ji Li ◽  
Mincheng Zhang ◽  
Yong Mao ◽  
Yimao Li ◽  
Xiaoxia Zhang ◽  
...  
Keyword(s):  
Potential Role ◽  
Aristolochic Acid ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Aquaporin 1 ◽  
Aristolochic Acid I

Epithelial-Mesenchymal Transition in Prostate Cancer and the Potential Role of Kallikrein Serine Proteases

2007 ◽  
Vol 185 (1-3) ◽  
pp. 111-115 ◽  
Author(s):  
Mitchell G. Lawrence ◽  
Tara L. Veveris-Lowe ◽  
Astrid K. Whitbread ◽  
David L. Nicol ◽  
Judith A. Clements
Keyword(s):  
Prostate Cancer ◽  
Serine Proteases ◽  
Potential Role ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition

scholarly journals Helicobacter pylori-induced epithelial-mesenchymal transition, a potential role of gastric cancer initiation and an emergence of stem cells

2015 ◽  
Vol 36 (5) ◽  
pp. 553-563 ◽  
Author(s):  
Yoon Jin Choi ◽  
Nayoung Kim ◽  
Hyun Chang ◽  
Hye Seung Lee ◽  
Seon Mee Park ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Helicobacter Pylori ◽  
Potential Role ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Cancer Initiation

Magnesium Chloride is an Effective Therapeutic Agent for Prostate Cancer

2018 ◽  
Vol 8 (1) ◽  
pp. 62 ◽  
Author(s):  
Julianna Maria Santos ◽  
Fazle Hussain
Keyword(s):  
Prostate Cancer ◽  
Magnesium Chloride ◽  
Epithelial Mesenchymal Transition ◽  
Chromatin Condensation ◽  
Myosin Ii ◽  
In Vivo Studies ◽  
Migration Speed ◽  
Mesenchymal Transition

Background: Reduced levels of magnesium can cause several diseases and increase cancer risk. Motivated by magnesium chloride’s (MgCl2) non-toxicity, physiological importance, and beneficial clinical applications, we studied its action mechanism and possible mechanical, molecular, and physiological effects in prostate cancer with different metastatic potentials.Methods: We examined the effects of MgCl2, after 24 and 48 hours, on apoptosis, cell migration, expression of epithelial mesenchymal transition (EMT) markers, and V-H+-ATPase, myosin II (NMII) and the transcription factor NF Kappa B (NFkB) expressions.Results: MgCl2 induces apoptosis, and significantly decreases migration speed in cancer cells with different metastatic potentials.  MgCl2 reduces the expression of V-H+-ATPase and myosin II that facilitates invasion and metastasis, suppresses the expression of vimentin and increases expression of E-cadherin, suggesting a role of MgCl2 in reversing the EMT. MgCl2 also significantly increases the chromatin condensation and decreases NFkB expression.Conclusions: These results suggest a promising preventive and therapeutic role of MgCl2 for prostate cancer. Further studies should explore extending MgCl2 therapy to in vivo studies and other cancer types.Keywords: Magnesium chloride, prostate cancer, migration speed, V-H+-ATPase, and EMT.

Effect of Annexins Translocated in Extracellular Vesicles on Tumorigenesis

2020 ◽  
Vol 20 ◽  
Author(s):  
Qionghui Wu ◽  
Haidong Wei ◽  
Wenbo Meng ◽  
Xiaodong Xie ◽  
Zhenchang Zhang ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Extracellular Vesicles ◽  
Immune Cell ◽  
Epithelial Mesenchymal Transition ◽  
Main Role ◽  
Tumor Cell Adhesion ◽  
Mesenchymal Transition ◽  
Calcium Dependent ◽  
Tumor Neovascularization

: Annexin, a calcium-dependent phospholipid binding protein, can affect tumor cell adhesion, proliferation, apoptosis, invasion and metastasis, as well as tumor neovascularization in different ways. Recent studies have shown that annexin exists not only as an intracellular protein in tumor cells, but also in different ways to be secret outside the cell as a “crosstalk” tool for tumor cells and tumor microenvironment, thus playing an important role in the development of tumors, such as participating in epithelial-mesenchymal transition, regulating immune cell behavior, promoting neovascularization and so on. The mechanism of annexin secretion in the form of extracellular vesicles and its specific role is still unclear. This paper summarizes the main role of annexin secreted into the extracellular space in the form of extracellular vesicles in tumorigenesis and drug resistance and analyzes its possible mechanism.

scholarly journals Correction to: The role of epithelial–mesenchymal transition (EMT)-associated genes during gonadogenesis of albino rat

2020 ◽  
Vol 81 (1) ◽  
Author(s):  
Lina A. Aeshra ◽  
Maiada Moustafa ◽  
Mohammed I. Y. Elmallah ◽  
Said Abdelrahman Salih ◽  
Ibrahim Y. Abdel Kader
Keyword(s):  
Epithelial Mesenchymal Transition ◽  
Albino Rat ◽  
Mesenchymal Transition
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