Radiotherapy for childhood cancer and subsequent thyroid cancer risk: a systematic review

2018 ◽  
Vol 33 (12) ◽  
pp. 1139-1162 ◽  
Author(s):  
Eva Lorenz ◽  
Peter Scholz-Kreisel ◽  
Dan Baaken ◽  
Roman Pokora ◽  
Maria Blettner
2011 ◽  
Vol 21 (1) ◽  
pp. 92-101 ◽  
Author(s):  
Lene H.S. Veiga ◽  
Parveen Bhatti ◽  
Cécile M. Ronckers ◽  
Alice J. Sigurdson ◽  
Marilyn Stovall ◽  
...  

Thyroid ◽  
2018 ◽  
Vol 28 (2) ◽  
pp. 220-228 ◽  
Author(s):  
Mi Ah Han ◽  
Jin Hwa Kim

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A871-A871
Author(s):  
Je Ern Chooi ◽  
Abiramie Ravindiran ◽  
Saba P Balasubramanian

Abstract Clinically unapparent thyroid nodules discovered serendipitously on imaging for non-thyroid indications are termed ‘thyroid incidentalomas’. The increase in the detection of these incidentalomas (which are known to be very common) has been attributed to the widespread use of diagnostic imaging and the increase in sensitivity and resolution of these modalities. It is unclear whether these incidentalomas have a lower prevalence of thyroid cancer or slower tumour progression compared to symptomatic thyroid nodules. This systematic review aimed to determine the risk of malignancy in incidentally detected thyroid nodules and its impact on prognosis in patients with thyroid cancer. PubMed and MEDLINE® on Web of Science databases were searched from inception to March 2020 for English language articles reporting on human studies of thyroid cancer risk and/or prognosis in incidental and non-incidental nodules. Quality of included studies was assessed using the Newcastle-Ottawa Scale (NOS). Seventeen observational studies published between 1998 and 2018 were eligible for analysis; 4 studies reported on risk, 8 studies on prognosis and 5 studies on both risk and prognosis. In the risk review, the odds ratios calculated from the six case-control studies (3246 patients) ranged from 0.64 to 2.86 whilst the relative risks calculated from the three cohort studies (489 patients) ranged from 0.13 to 6.27. NOS score for included risk studies (n=9) ranged from 22.2% to 66.7%. A meta-analysis of the eligible case-control studies (n=3) showed a non-significant summated odds ratio of 1.04 (95% CI=0.63-1.70, p=0.88). In the prognosis review of thirteen studies, three direct and thirteen indirect markers of prognosis were compared between the incidental (1923 patients) and non-incidental (2639 patients) groups. NOS score for included prognosis studies ranged from 66.7% to 100%. Incidentally detected thyroid nodules were significantly more likely to be smaller, have lower rates of extra-thyroidal and extra-nodal extension and lymph node metastasis, and interestingly more likely to have advanced disease. Other indirect prognostic markers were not shown to be significantly different between the two groups. A meta-analysis was not possible but incidentally detected thyroid cancer had better progression-free and overall survival; this finding may be affected by ‘lead time’ bias. Current evidence suggests that the investigation and management of thyroid nodules should not be influenced by the mode of detection.


Author(s):  
Selcuk Dagdelen ◽  
Nese Cinar ◽  
Tomris Erbas

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
QingAn Yu ◽  
XiaoYing Lv ◽  
KunPeng Liu ◽  
DaKun Ma ◽  
YaoHua Wu ◽  
...  

Associations have been demonstrated between fertility drugs and a variety of hormone-sensitive carcinomas. The purpose of this study was to determine the relationship between fertility drugs used in the treatment of female infertility and the risk of thyroid cancer. To investigate the clinical significance of fertility drugs used for the treatment of female infertility and the risk associated with thyroid cancer, we performed a literature search using PubMed, MEDLINE, the Cochrane Library, the Web of Science, and EBSCOHOST for comparative studies published any time prior to July 21, 2017. The studies included women who were treated for infertility with fertility drugs, such as clomiphene citrate, gonadotropins, or other unspecified fertility agents, which reported the incidence of thyroid cancer as the main outcome. Eight studies were included in the meta-analyses. Among women with infertility, there was a significant positive association between thyroid cancer risk and the use of fertility drugs (relative risk [RR] = 1.35; 95% confidence interval [CI] 1.12–1.64; P=0.002). Additionally, among women with infertility, the use of clomiphene citrate was associated with an increased risk of thyroid cancer compared to women who did not use fertility drugs (RR = 1.45; 95% CI 1.12–1.88; P=0.005). After pooling results, we found that the parity status of infertile women using fertility drugs was not associated with thyroid cancer risk (RR = 0.99; 95% CI 0.61–1.58, P=0.95). In summary, clomiphene citrate (the most commonly used fertility drug) and other fertility drugs are associated with an increased risk of thyroid cancer.


2018 ◽  
Vol 613-614 ◽  
pp. 679-686 ◽  
Author(s):  
Xufeng Fei ◽  
Zhaohan Lou ◽  
George Christakos ◽  
Qingmin Liu ◽  
Yanjun Ren ◽  
...  

2020 ◽  
Vol 12 (8) ◽  
pp. 492-498
Author(s):  
Navdeep Singh ◽  
Sandeep Singh Lubana ◽  
Saurabh Arora ◽  
Issac Sachmechi

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