Chronic heart failure: a disease of the brain

2018 ◽  
Vol 24 (2) ◽  
pp. 301-307 ◽  
Author(s):  
Ram B. Singh ◽  
Krasimira Hristova ◽  
Jan Fedacko ◽  
Galal El-Kilany ◽  
Germaine Cornelissen
2017 ◽  
Vol 8 (2) ◽  
pp. 59-62
Author(s):  
N. S Akimova ◽  
I. M Sokolov ◽  
T. V Martynovich ◽  
Yu. G Shvarts

The aim of the study was to examine the dependence of functional and morphological changes in the brain and factors of the severity of chronic heart failure. Materials and methods: 54 patients with chronic heart failure of ischemic genesis, I-IV functional class were cognitive tests, echocardiography, nuclear magnetic resonance imaging of the brain. Results. With an increase in the functional class of chronic heart failure, the worst results of Veksler-5 and 7 cognitive subtests are noted, a smaller thickness of gray matter of parietal lobes, lower diffusion coefficients of water molecules in the white matter of the parietal and occipital lobes, and a smaller thickness of the middle legs of the cerebellum. Comparative analysis of the central nervous system state indices in patients with chronic heart failure with different fraction of left ventricular ejection did not show significant differences. The conclusion. The established results confirm the significance of the functional class of chronic heart failure as a marker of cognitive dysfunction and pathological changes in both gray and white matter of the brain, whereas the size of the left ventricular ejection fraction is obviously less useful in this respect.


1998 ◽  
Vol 4 (2) ◽  
pp. 139-144 ◽  
Author(s):  
Takayuki Sato ◽  
Ryoich Yoshimura ◽  
Toru Kawada ◽  
Toshiaki Shishido ◽  
Hiroshi Miyano ◽  
...  

2020 ◽  
Author(s):  
Mark Dayer ◽  
David H MacIver ◽  
Stuart D Rosen

The view that chronic heart failure was exclusively a disease of the heart dominated the cardiovascular literature until relatively recently. However, over the last 40 years it has increasingly come to be seen as a multisystem disease. Aside from changes in the sympathetic and parasympathetic nervous systems and the renin-angiotensin-aldosterone system, adaptations to the lungs, muscles and gastrointestinal tract have been clearly documented. It is clear that the brain and CNS are also affected in patients with heart failure, although this is often under recognized. The purpose of this review is to summarize the changes in the structure and biochemical function of the CNS in patients with chronic heart failure and to discuss their potential importance.


2017 ◽  
Vol 8 (2) ◽  
pp. 59-62
Author(s):  
N.S. Akimova ◽  
◽  
I.M. Sokolov ◽  
T.V. Martynovich ◽  
Yu.G. Shvarts ◽  
...  

2021 ◽  
Vol 16 (2) ◽  
pp. 176-182
Author(s):  
Tonkykh Natalia A. ◽  
◽  
Dubovaya Anna V. ◽  
Usenko Nadezhda A. ◽  
Kurkurina Elena A. ◽  
...  

The article presents the experience of using original methods of memorizing information for teaching interns of all specialties. A number of pedagogical principles have been revised and updated to optimize learning. During training in the profession of a doctor, one of the most difficult elements of cognition is memorizing the doses of drugs, the ability to apply them in practice. During training in the profession of a doctor, one of the most difficult cognition elements is memorizing the doses of drugs, the ability to apply them in practice. The human brain has hard time memorizing numerical information until it is converted into visual images that the brain can understand. The authors have used the way of presenting difficult to memorize material in an interesting poetic form and the method of figurative nomination using the figurative-logical thinking of interns through the development of emotionally colored associative connections. 64 interns of various specialties who took part in the practical lesson “Acute and chronic heart failure in children” were randomly divided into two groups. In the main group (32 people, 50,0 %) the authors used the method of figurative nomination and mnemonic techniques, in the control group (32 people, 50,0 %) there was a standard methodological presentation of the material. The use of these methods in training interns improved the efficiency of memorizing information for a long time by 31,8 %. Keywords: methods of teaching, mnemonics, memory, figurative nomination technique, education


2016 ◽  
Vol 23 (3) ◽  
Author(s):  
Іuliia P Pashkova

In the development of essential hypertension cardiac remodeling is determined by both hemodynamic and neurohumoral factors. The influence of hemodynamic factors is sufficiently studied, while the role of stimulating and inhibiting humoral agents in the development of cardiac remodeling is completely unknown. Therefore, the study of structural and functional indicators of the myocardial state in patients with essential hypertension and heart failure being carriers of different BNP genotypes is promising in terms of the possible role of the BNP gene polymorphisms in the development and progression of cardiac disease manifestations.The objective of the research was to examine structural and functional indicators of the myocardial state in men with essential hypertension and co-existent chronic heart failure Class IIА being carriers of different variants of the brain natriuretic peptide gene at the age of 40-60 years living in Podillia region.Materials and methods. Genotyping of the brain natriuretic peptide gene was performed using the polymerase chain reaction. Structural and functional indicators of the myocardial state were assessed by cardiac ultrasound with ultrasound device ULTIMA RA (Radmir, Ukraine).Results. The results revealed that among men with stage II essential hypertension the frequency of the T381T genotype of the brain natriuretic peptide gene was 35.48% and 64.52% of patients were carriers of C allele (р<0.001); among patients with essential hypertension and co-existent chronic heart failure Class IIА the frequency of the T381T genotype was 42.00% and 58.00% of patients were carriers of C allele (р≤0.05). In patients with chronic heart failure Class IIА being carriers of the T381T genotype the size and volume of the left ventricle at the end of systole and diastole were significantly larger, the indicators of the left ventricular myocardium mass index and left ventricular wall thickness were higher than in carriers of C allele (р<0.05). The indicators of the size and volume of the left ventricle, posterior left ventricular wall thickness and systemic hemodynamics regardless of the brain natriuretic peptide genotype were significantly higher in men with essential hypertension and co-existent chronic heart failure Class IIА compared to patients with stage II essential hypertension (p<0.05).Conclusion. In patients with symptoms of chronic heart failure Class IIA being carriers of the Т381Т genotype the size and volume of the left ventricle at the end of systole and diastole were significantly larger, the indicators of the left ventricular myocardium mass index and left ventricular wall thickness were higher than in carriers of C allele of the brain natriuretic peptide gene (р<0.05). In patients with essential hypertension and co-existent chronic heart failure Class IIА EF<45% being carriers of the Т381Т genotype, the highest indicators of the size of the left ventricle, end-systolic volume index, end-diastolic volume index, left ventricular myocardium mass index were observed. The inheritance of the T381T genotype by patients with symptoms of chronic heart failure Class IIA was found to be associated with higher levels of systolic blood pressure and diastolic blood pressure irrespective of the state of left ventricular systolic function.


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