Comparison of serum thiol–disulphide homeostasis and total antioxidant–oxidant levels between exudative age-related macular degeneration patients and healthy subjects

Background. Recent clinical studies have shown that, in some degenerative retinal diseases, like age-related macular degeneration (AMD), the sensitivity of the rods decreases more rapidly than the sensitivity of the cones. The aim of this study was to evaluate if there is a correlation between the presence of hard drusen at the macular level and the rod damage responsible for the reduction in scotopic retinal sensitivity in subjects at risk for AMD.Methods. The authors selected 24 subjects (14 men and 10 women) with an average age of 67.25 ± 5.7 years. Macular hard drusen were present in 50% of the subjects at thefundus oculiexam. The researchers evaluated the retinal sensitivity to light in mesopic and scotopic conditions of each subject with an MP-1 scotopic microperimeter (MP-1S).Results. In subjects with hard drusen in thefundus oculiexamination, there was a statistically significant reduction in scotopic retinal sensitivity, while the mesopic retinal sensitivity was not compromised.Conclusion. This study revealed how the presence of hard drusen at the macular level is associated with a reduction in scotopic retinal sensitivity compared to a control group of healthy subjects. Retinal functionality in a scotopic setting examined with MP-1S could be useful in early diagnosis of AMD.

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Association of Age-Related Macular Degeneration with Erythrocyte Antioxidant Enzymes Activity and Serum Total Antioxidant Status

Oxidative Medicine and Cellular Longevity ◽

10.1155/2015/804054 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 9

Author(s):

Ivna Plestina-Borjan ◽

Damir Katusic ◽

Maria Medvidovic-Grubisic ◽

Daniela Supe-Domic ◽

Kajo Bucan ◽

...

Keyword(s):

Oxidative Stress ◽

Antioxidant Enzymes ◽

Macular Degeneration ◽

Antioxidant Status ◽

Total Antioxidant Status ◽

Age Related Macular Degeneration ◽

Enzymes Activity ◽

Age Related ◽

Total Antioxidant ◽

Gpx Activity

The aim was to estimate association of the oxidative stress with the occurrence of age-related macular degeneration (AMD). The activities of erythrocyte antioxidant enzymes: superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) and additionally serum total antioxidant status (TAS) were used as indicators of the oxidative stress level. 57 AMD patients (32 early and 25 late AMD) and 50 healthy, age and gender matched controls were included. GPx activity (P<0.001) and serum TAS (P=0.015) were significantly lower in AMD patients. The difference was not significant for SOD or CAT activities. Significant interaction between GPx and SOD was detected (P=0.003). At high levels of SOD activity (over 75th percentile), one standard deviation decrease in GPx increases the odds for AMD for six times (OR = 6.22;P<0.001). ROC analysis revealed that combined values of GPx activity and TAS are significant determinants of AMD status. Accuracy, sensitivity, specificity, and positive and negative predictive values were 75%, 95%, 52%, 69%, and 90%, respectively. The study showed that low GPx activity and TAS are associated with AMD. SOD modulates the association of GPx and AMD. The results suggest that erythrocyte antioxidant enzymes activity and serum TAS could be promising markers for the prediction of AMD.

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Comparison of time-resolved autofluorescence in the eye-ground of healthy subjects and patients suffering from age-related macular degeneration

10.1117/12.633032 ◽

2005 ◽

Author(s):

Dietrich Schweitzer ◽

Frank Schweitzer ◽

Martin Hammer ◽

Stefan Schenke ◽

Sandra Richter

Keyword(s):

Macular Degeneration ◽

Healthy Subjects ◽

Age Related Macular Degeneration ◽

Time Resolved ◽

Age Related

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Serum 25-hydroxy vitamin D levels in age-related macular degeneration

10.21203/rs.3.rs-985190/v1 ◽

2021 ◽

Author(s):

Antonio Pérez Serena ◽

Daisy Paola Martínez Betancourt ◽

Fernando González del Valle ◽

Jose María Ruiz Moreno

Keyword(s):

Vitamin D ◽

Macular Degeneration ◽

Healthy Subjects ◽

Age Related Macular Degeneration ◽

Fundus Photography ◽

Control Group ◽

Neovascular Amd ◽

Age Related ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D

Abstract Purpose The aim of this study was to determine the 25-hydroxy vitamin D (25(OH)D) levels in age-related macular degeneration (AMD) patients. Methods Age-related macular degeneration (AMD) patients were classified into four groups: early AMD (N =10), intermediate AMD (N=12), advanced atrophic AMD (N=19) and advanced neovascular AMD (N=52) after undergoing fundus photography. Serum 25(OH)D levels of all subjects were evaluated. From a random control group of 326 patients whose 25(OH)D levels had been measured, a group of 93 were selected to match the age range of the AMD group. We measured 25(OH)D levels during the same period to rule out seasonal variation. Results A total of 93 AMD patients (36 males and 57 females) and 93 healthy individuals (39 males and 54 females) were enrolled in this study with the mean age of 78.96±8.46 vs. 78.80±8.35, respectively. The patients affected by AMD had statistically significant lower 25(OH)D levels (15±10 ng/mL) than the healthy subjects control group (21±14 ng/mL) (p = 0.004). However, the median 25(OH)D levels in early AMD, intermediate AMD, advanced atrophic AMD and advanced neovascular AMD (12.5±7.3; 15±11; 15±8 and 17±11.5, respectively) were not statistically significant (p = 0.442). Conclusion This study shows that patients affected by AMD had lower vitamin D levels compared to healthy subjects. Further research is necessary to investigate the possible association between 25(OH)D levels and AMD.

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THE ULTRA-LATE PHASE OF INDOCYANINE GREEN ANGIOGRAPHY FOR HEALTHY SUBJECTS AND PATIENTS WITH AGE-RELATED MACULAR DEGENERATION

Retina ◽

10.1097/00006982-200206000-00009 ◽

2002 ◽

Vol 22 (3) ◽

pp. 309-316 ◽

Cited By ~ 6

Author(s):

KEISUKE MORI ◽

PETER L. GEHLBACH ◽

YOKO NISHIYAMA ◽

TATSUYA DEGUCHI ◽

SHIN YONEYA

Keyword(s):

Indocyanine Green ◽

Macular Degeneration ◽

Healthy Subjects ◽

Indocyanine Green Angiography ◽

Late Phase ◽

Age Related Macular Degeneration ◽

Age Related

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Age related macular degeneration (ARMD) – pathophysiological and clinical features and therapeutic concepts

Therapeutische Umschau ◽

10.1024/0040-5930.58.1.28 ◽

2001 ◽

Vol 58 (1) ◽

pp. 28-35 ◽

Cited By ~ 1

Author(s):

Ursula Körner-Stiefbold

Keyword(s):

Macular Degeneration ◽

Clinical Features ◽

Altersbedingte Makuladegeneration ◽

Age Related Macular Degeneration ◽

Genetische Faktoren ◽

Age Related ◽

Therapeutic Concepts

Die altersbedingte Makuladegeneration (AMD) ist eine der häufigsten Ursachen für einen irreversiblen Visusverlust bei Patienten über 65 Jahre. Nahezu 30% der über 75-Jährigen sind von einer AMD betroffen. Trotz neuer Erkenntnisse in der Grundlagenforschung ist die Ätiologie, zu der auch genetische Faktoren gehören, noch nicht völlig geklärt. Aus diesem Grund sind die Behandlungsmöglichkeiten zum jetzigen Zeitpunkt noch limitiert, so dass man lediglich von Therapieansätzen sprechen kann. Die derzeit zur Verfügung stehenden Möglichkeiten wie medikamentöse, chirurgische und laser- und strahlentherapeutische Maßnahmen werden beschrieben.

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