scholarly journals Exploring the Role of Empathy in Understanding the Social-Cognitive Profile for Individuals Referred for Autism Spectrum Disorders Assessment in Adulthood

2018 ◽  
Vol 50 (5) ◽  
pp. 1470-1478 ◽  
Author(s):  
Victoria Russ ◽  
Hanna Kovshoff ◽  
Tony Brown ◽  
Patricia Abbott ◽  
Julie A. Hadwin
Keyword(s):  
Autism Spectrum Disorders ◽  
Social Cognitive ◽  
Autism Spectrum ◽  
Cognitive Profile ◽  
The Social ◽  
Spectrum Disorders

A Neuroendocrine Therapeutic Approach with the Pineal Hormone Melatonin, Cannabidiol and Oxytocin (MCO regimen) in the Treatment of the Autism Spectrum disorders

2020 ◽  
Author(s):  
Giuseppe Di Fede
Keyword(s):  
Autism Spectrum Disorders ◽  
Brain Structures ◽  
Autism Spectrum ◽  
Sleep Regulation ◽  
Cannabinoid System ◽  
The Social ◽  
Pineal Function ◽  
Spectrum Disorders ◽  
And Control

After several years of researches to identify possible neurochemical alterations, at present it is known that autism is characterized and induced by at least three neuroendocrine deficiencies, involving the pineal function and the secretion of its most investigated hormone, melatonin (MLT), brain cannabinoid system, and the neurohypophyseal production of oxytocin (OT). Because of the fundamental role of MLT in sleep regulation, brain cannabinoid system in pleasure perception and control of anxiety, and OT in the affective life, these three neuroendocrine deficiencies might explain at least in part the symptomatology of autism. Therefore, autism-related neurochemical anomalies would involve the same main brain structures responsible for the conscious and the affective life, as well as for pleasure perception. On these bases, a preliminary study was performed to evaluate the influence of a progressive neuroendocrine. Substitutive treatment in autistic children. The study included 30 consecutive patients, by treating the first 12 subjects with the only MLT (100 mg/day in the dark period), the next 12 subjects with MLT plus cannabidiol. (CBD) (10 mg twice/day), and the remaining 6 subjects with MLT plus CBD plus OT (2 mg twice/day). All therapies were orally administered. MLT alone was mainly active in the treatment of sleep disorders. The association with CBD improved the control of anxiety. Finally, the further association with OT was also effective in improving the social and affective relationships. These preliminary results would suggest the possibility to treat the autism spectrum disorders by correcting their main neuroendocrine deficiencies through an exogenous administration.

Biomedical treatment versus the social functioning of a child with autism spectrum disorders

2020 ◽  
Vol LXXXI (4) ◽  
pp. 273-282
Author(s):  
Maja Jędruszczak ◽  
Danuta Al-Khamisy
Keyword(s):  
Autism Spectrum Disorders ◽  
Social Functioning ◽  
Treatment Guidelines ◽  
Social Behaviors ◽  
Autism Spectrum ◽  
The Social ◽  
Spectrum Disorders ◽  
The Difference ◽  
Biomedical Treatment

This article looks at the findings of a study whose aim was to explore the difference in the social functioning of a student with autism spectrum disorders before biomedical treatment was introduced and during the treatment. It provides information on changes in the participant’s social behaviors collected with the use of the case study method and a short description of biomedical treatment guidelines and elements. Analysis of the information gathered shows that after 12 months from the beginning of biomedical treatment for autism, positive changes occurred in the participant's social functioning. He made the most progress in fulfilling the role of a friend and the least progress in social behaviors toward his family.

Critical role of dysfunctional mitochondria and defective mitophagy in autism spectrum disorders

2021 ◽  
Vol 168 ◽  
pp. 138-145
Author(s):  
Yuan-Mei Wang ◽  
Ming-Yue Qiu ◽  
Qing Liu ◽  
Huang Tang ◽  
Hong-Feng Gu
Keyword(s):  
Autism Spectrum Disorders ◽  
Critical Role ◽  
Autism Spectrum ◽  
Spectrum Disorders

scholarly journals Mutation analysis of the NRXN1 gene in autism spectrum disorders

2016 ◽  
Vol 19 (2) ◽  
pp. 17-22 ◽  
Author(s):  
H Onay ◽  
D Kacamak ◽  
AN Kavasoglu ◽  
B Akgun ◽  
M Yalcinli ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Autism Spectrum Disorders ◽  
Children And Adolescents ◽  
Gene Mutations ◽  
Autism Spectrum ◽  
Syndromic Autism ◽  
Spectrum Disorders ◽  
Strong Candidate ◽  
Reduced Penetrance

AbstractThe aim of this study was to identify the sequence mutations in the Neurexin 1 (NRXN1) gene that has been considered as one of the strong candidate genes. A total of 30 children and adolescents (aged 3-18) with non syndromic autism were enrolled this study. Sequencing of the coding exons and the exon-intron boundaries of the NRXN1 gene was performed. Two known mutations were described in two different cases. Heterozygous S14L was determined in one patient and heterozygous L748I was determined in another patient. The S14L and L748I mutations have been described in the patients with autism before. Both of these mutations were inherited from their father. In this study, two of 30 (6.7%) autism spectrum disorder (ASD) patients carrying NRXN1 gene mutations were detected. It indicates that variants in the NRXN1 gene might confer a risk of developing nonsyndromic ASD. However, due to the reduced penetrance in the gene, the causal role of the NRXN1 gene mutations must be evaluated carefully in all cases.

Autism Spectrum Disorders: A Research Review for School Counselors

2013 ◽  
Vol 16 (4) ◽  
pp. 2156759X1501604
Author(s):  
Richard W. Auger
Keyword(s):  
Autism Spectrum Disorders ◽  
School Counselors ◽  
Autism Spectrum ◽  
Research Literature ◽  
Research Review ◽  
Social Deficits ◽  
Increased Risk ◽  
The Social ◽  
Students With Autism ◽  
Spectrum Disorders

The number of students with autism spectrum disorders (ASD) has risen significantly in recent years (CDC, 2012), and students with ASD present unique challenges to schools and school counselors. This article presents a synthesis of recent research literature related to ASD for the purpose of providing school counselors with assistance in understanding and addressing the needs of students with ASD. Specific areas of focus include the prevalence, developmental course, and defining characteristics of ASD, and research on the effectiveness of interventions for students with ASD. Students with ASD are at increased risk for a range of problems, including social deficits and limitations, anxiety, aggression, peer victimization, and underachievement (Ashburner, Ziviani, & Rodger, 2010). Interventions to address the social deficits of students with ASD have shown promise but also have been found to lack results that are generalizable and that persist over time (Schreiber, 2011). This article provides specific recommendations for school counselors.

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