Nano/Microrobots Line Up for Gastrointestinal Tract Diseases: Targeted Delivery, Therapy, and Prevention

Nano/microrobots (NMRs) are tiny devices that can convert energy into motion and operate at nano/microscales.54 Especially in biomedical research, NMRs have received much attention over the past twenty years because of their excellent capabilities and great potential in various applications, including on-demand drug delivery, gene and cell transport, and precise microsurgery. Reports published in recent years show that synthetic nano/microrobots have promising potential to function in the gastrointestinal (GI) region, particularly in terms of drug delivery. These tiny robots were able to be designed in such a way that they propel in their surroundings (biological media) with high speed, load cargo (drug) efficiently, transport it safely, and release upon request successfully. Their propulsion, retention, distribution, and toxicity in the GI tract of mice has been evaluated. The results envisage that such nano/microrobots can be further modified and developed as a new-generation treatment of GI tract diseases. In this minireview, we focus on the functionality of micro/nanorobots as a biomedical treatment system for stomach/intestinal diseases. We review the research progress from the first in vivo report in December 2014 to the latest in August 2021. Then, we discuss the treatment difficulties and challenges in vivo application (in general) and possible future development routes.

Enhancement Research on Piezoelectric Performance of Electrospun PVDF Fiber Membranes with Inorganic Reinforced Materials

The electrospun PVDF fiber membranes with the characteristics of light weight, strong signal and measurability, have been widely applied in the fields of environment, energy sensors and biomedical treatment. Due to the weakness of the piezoelectric and service properties, the conventional PVDF fiber membranes cannot meet the operating requirements. Based on the obtained optimal technological parameter of electrospun pure PVDF fiber membranes (P-PVDF) in the previous experiment (unpublished), three inorganic reinforced substances (AgNO3, FeCl3·6H2O, nanographene) were respectively used to dope and modify PVDF to prepare composite fiber membranes with the better piezoelectric performance. The morphology and crystal structure of the hybrid fiber membranes were observed and detected by scanning electron microscopy and X-ray diffraction, respectively. The results showed that the dopant could effectively promote the formation of β-phase, which can enhance the piezoelectric performance. The mechanical properties test and piezoelectric performance test exhibited that the static flexural strength, the elastic modulus, and the piezoelectric performance were improved with the addition of dopant. In addition, the influence on the addition of dopant and the doping modification mechanism were discussed. Finally, the conclusions showed that the minimum average diameter was obtained with the 0.3 wt% addition of AgNO3; the piezoelectric performance reached the strongest with the 0.8 wt% addition of FeCl3·6H2O; the mechanical properties were best with the 1.0 wt% addition of nanographene.

Whose stories are told and who is made responsible? Human-interest framing in health journalism in Norway, Spain, the U.K. and the U.S.

Human-interest narratives are journalistic tools to captivate and engage the audience, influence public opinion and bring revenue to media organizations. This paper analyses how human-interest narratives are used in contemporary health journalism across media systems and health systems. Based on a comparative content analysis of Norwegian, Spanish, U.K. and U.S. newspapers (2016–2017), it studies how human-interest stories are contextualized, health problems explained and responsibility attributed. The article reveals a complex picture of the role of human-interest stories in health coverage. In line with expectations, the study finds that human-interest stories do tend to emphasize individual biomedical treatment of illness and to privilege idealized victims who fit the routines of dominant media dramaturgy. In contrast to theories that consider personalization of news as an individualization of responsibility and dumbing down of public debate, however, the study finds that human-interest narratives are also used to explain health as a structural phenomenon and a collective responsibility, appealing to political intervention and accountability of health authorities. Such claims are more prominent in European human-interest health stories and less frequent in the more strongly commercialized U.S. health and media system.

Behavioural and psychosocial interventions for pain management

Patients with advanced disease commonly report pain as one of their most feared and distressing symptoms. A biomedical treatment approach that focuses solely on biological factors can be helpful but often fails to adequately address important psychological, social, and spiritual factors that can contribute to pain. Behavioural and psychosocial approaches to understanding and treating pain in patients with advanced disease can be quite helpful in this context. These approaches not only have the potential to reduce pain but also improve patients’ overall adjustment to life-limiting disease. This chapter provides an overview of these approaches. It is divided into four sections, including a summary of the prevalence and undertreatment of pain in patients with advanced disease, a rationale for behavioural and psychosocial approaches to pain management, an overview of the most common and effective behavioural and psychosocial approaches, and clinical considerations and future directions.

Atmospheric plasma jet device for versatile electron microscope grid treatment

Atmospheric pressure plasmas have been widely applied in surface modification and biomedical treatment due to its ability to generate highly reactive radicals and charged particles. In cryogenic electron microscopy (cryo-EM), plasmas have been used in eliminating the surface contaminants as well as generating the hydrophilic surface to embed the specimen on grids. Particularly, plasma treatment is a prerequisite for negative stain and quantifoil grids,which are coated with hydrophobic carbon on the grid surface. Here we introduce a nonthermal atmospheric plasma jet system as an alternative new tool for surface treatment. Unlike the conventional glow discharger, we found that the plasma jet system successfully cleans the grid surface and introduces hydrophilicity on grids in the ambient environment without introducing a vacuum. Therefore, we anticipate the plasma jet system will be beneficial in many aspects, such as cost-effective, convenient, versatile, and potential applications in surface modification for both negative stain and cryo-EM grid treatment.

Investigating the factors behind differences in ‘lay’ and ‘expert’ medical knowledge in the context of fever treatment in Yangon, Myanmar.

How is treatment seeking behaviour influenced by contrasting medical discourses? This paper uses the context of fever patients in Yangon, Myanmar to investigate the factors behind differences between ‘lay’ and ‘expert’ medical knowledge, which consequently guide the treatment seeking behaviour of hospital and clinic patients in Myanmar’s second largest city. By conducting the deductive thematic analysis of secondary qualitative data from both patients and medical doctors using an adapted form of Amartya Sen’s capability approach framework, this cross-sectional study uncovers how: education, socially rooted collective knowledge and unregulated pharmacies drive differences between ‘lay’ and ‘expert’ medical knowledge and therefore dictate treatment seeking behaviour. The results of this paper highlight the interdisciplinary nature of health, meaning health systems should be considered within their sociological, political and economic contexts. The current omission of traditional health discourse within the prevailing Burmese health system may limit the successfulness of biomedical treatment. Appreciating the complexity of how health is understood by populations, specifically how traditional medicine and biomedicine coexist within the Burmese context can allow policymakers to form a stronger health system by creating contextualised policies and health interventions for the general public that cater to the diversity of narratives within health.

The Nurse or Midwife at the Crossroads of Caring for Patients With Suicidal and Rigid Religious Ideations in Africa

Nurses and midwives are the majority of healthcare professionals globally, including Africa, and they provide care at all levels of the health system including community levels. Nurses and midwives contribute to the care of patients with rigid or dogmatic religious beliefs or those with suicidal ideations. This review paper discusses acute and chronic diseases that have suicidal tendencies such as terminal cancer, diseases with excruciating pain, physical disability, stroke, end-stage renal failure, and diabetics who are amputated. It was reiterated that nurses and midwives taking care of these patients should be alert and observant to identify their suicidal tendencies. The paper also discusses religious or spiritual inclinations that negatively affect healthcare access and adherence, especially to biomedical or western medicine. It was emphasized that some religious beliefs do not allow their followers to employ biomedical treatment and nurses and midwives should not impose their faith on patients and their families. The paper ends with a discussion on the specific roles of nurses and midwives in the care of patients with suicidal ideations such as assessment, counseling, administering medication, observation, social interaction, ensuring safety measures, and providing an enabling environment for the family to part of the care and for the observation of religious coping strategies. Nurses and midwives should enhance their knowledge and skills on suicide and increase public education on suicide prevention and identification of those at risk.

Filtering Inequality: Screening and Knowledge in Senegal’s Topography of Hepatitis B Care

Only a fraction of the estimated tenth or so of Senegalese who are chronically infected with hepatitis B virus (HBV) have been diagnosed. Of these, few have been assessed for their risk of progressing to potentially fatal liver disease (indicating need for treatment), and fewer still are taking antiviral drugs. A massive gap between those needing and getting treatment is widely acknowledged among experts. But given that HBV and its biomedical treatment options are largely invisible in bodies, health data, care practices, public messaging, or mass media, how can we observe, ethnographically, the effects of constraints on and inequalities in treatment? What are the stakes of access to drugs, when this access is not being sought out, claimed, or enacted? This article tackles these questions by examining how HBV is being enacted in Senegal, but not necessarily in relation to antiviral treatment. I first describe the emergence, over the past decade and a half, of an exclusionary topography of HBV diagnosis and treatment. I introduce the notion of “filtration” to describe the effects of this topography on the formation of potential “subjects of access.” The diagnostic therapies and expertise required to determine need for treatment are expensive, urban, and largely privatized. Moreover, knowledge about HBV and its possibilities of care circulates in narrow and sparsely distributed channels. Only a tiny minority of persons are effectively “filtered into” care, while issues of access remain largely outside of public debate. I then move onto small-scale efforts, led by rural primary health workers and community associations, to raise awareness of and expand screening for HBV. Those driving information and screening either do not reveal that effective drugs exist or locate these beyond the reach of most of their audiences or patients. Why then do they do it? I examine the logics and effects of their work to identify the forms of inclusion, care, efficacy, and explanation these open up. At the same time, I seek to discern the indirect effects of unequal access to knowledge and resources in the ambivalence, uncertainties, and contradictions that pervade these efforts to inform, diagnose, and advise.

‘We're Hands-On People’: Healing Diabetes in the Absence of Traditional Healers in an Aboriginal Community in Northern Territory, Australia.

This study of a remote Aboriginal community in Australia’s Northern Territory in 2014 sought to understand diabetes from a local Aboriginal perspective. Participants drew on a variety of holistic healing methods in the absence of an individual or individuals identified as holding a healing role in the community. The study offers an alternative to the common assumption that all communities can identify specific individuals as Aboriginal healers who are central to maintaining Aboriginal beliefs and wellbeing who contribute to holistic health (Clarke 2008; Maher 1999; McDonald 2006; Seathre 2013; Williams 2011). This research found the seven adult Aboriginal diabetes patients participating in the longitudinal ethnographic study actively engaged in self-healing strategies. Moreover, diabetes clinicians could combine local remedies and biomedical treatment to heal diabetes within the clinic, as well as actively engaging the patient in their own treatment, effective to reduce the symptoms and prevalence of diabetes in Aboriginal populations.

Postcolonial Global Health, Post-Colony Microbes and Antimicrobial Resistance

Rather than ‘superbugs’ signifying recalcitrant forms of life that withstand biomedical treatment, drug resistant infections emerge within and are intricate with the exercise of social and medical power. The distinction is important, as it provides a means to understand and critique current methods employed to confront the threat of widespread antimicrobial resistance. A global health regime that seeks to extend social and medical power, through technical and market integration, risks reproducing a form of triumphalism and exceptionalism that resistance itself should have us pause to question. An alternative approach, based on a postcolonial as well as a ‘post-colony’ approach to health and microbes, provides impetus to challenge the assumptions and norms of global health. It highlights the potential contribution that vernacular approaches to human and animal health can play in altering the milieu of resistance.