Acrylic acid–methyl methacrylate copolymer for oral prolonged drug release

2010 ◽  
Vol 21 (9) ◽  
pp. 2583-2592 ◽  
Author(s):  
Saurabh Vijay ◽  
O. P. Sati ◽  
Dipak K. Majumdar
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Methyl Methacrylate ◽  
Acid Methyl ◽  
Methacrylate Copolymer ◽  
Prolonged Drug Release

Synthesis, Characterization and Safety Profiling of Eudragit-Based pHResponsive Hydrogels: A Promising Platform for Colonic Delivery of Losartan Potassium

2019 ◽  
Vol 16 (6) ◽  
pp. 548-564
Author(s):  
Shabina Mahmood ◽  
Manal Ali Buabeid ◽  
Kaleem Ullah ◽  
Ghulam Murtaza ◽  
Abdul Mannan ◽  
...  
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Drug Loading ◽  
Control Group ◽  
Colonic Delivery ◽  
Hydrophilic Drugs ◽  
Promising Tool ◽  
Inverse Results ◽  
Efficient Delivery ◽  
Prolonged Drug Release

Objective: The aim of the present study was to design an efficient delivery system with an anticipated swelling and drug release properties for a prolonged drug release as well as to target colon for various hydrophilic drugs. Methods: For this purpose, the pH-responsive hydrogel comprising a combination of Eudragit and acrylic acid was formed. The hydrogels were characterized for spectral (FTIR), thermal (TGA/DSC), structural (XRD), and morphological (SEM) investigations. Oral tolerability was assessed in rabbits for biocompatibility and oral use of the prepared hydrogels. Results: The results showed that an increased incorporation of Eudragit and cross-linking agent retorted the swelling, drug loading, and drug release properties at both acid (pH 1.2) and basic pH (pH 6.8 and 7.4) , while acrylic acid presented the inverse results. The oral tolerability and toxicity studies depicted that the developed hydrogels were safe up to 3800 mg/kg body weight and caused no hematological or histopathological changes when compared with the control group. Conclusion: Therefore, the newly developed formulations presented adequate swelling, drug loading, release behavior, and biocompatibility properties and thus can be used as a promising tool for the colonic delivery of various hydrophilic drugs.

ACRYLIC ACID/METHYL METHACRYLATE HYDROGELS. I. EFFECT OF COMPOSITION ON MECHANICAL AND THERMODYNAMIC PROPERTIES

2000 ◽  
Vol 37 (4) ◽  
pp. 307-321 ◽  
Author(s):  
Issa Katime ◽  
Elena Díaz de Apodaca ◽  
Eduardo Mendizábal ◽  
Jorge E. Puig
Keyword(s):  
Acrylic Acid ◽  
Thermodynamic Properties ◽  
Methyl Methacrylate ◽  
Acid Methyl

Research on the Influence of Stiffness of Copolymer(N-Tert-octylacrylamide/Acrylic acid/Methyl methacrylate/Butylaminoethyl Methacrylate/Hydroxypropyl Methacrylate) by Methyl Methacrylate and N-Tert-Octylacrylamide

2012 ◽  
Vol 557-559 ◽  
pp. 968-972 ◽  
Author(s):  
Jie Zhu ◽  
Weng Fa Xiao ◽  
Li Tao Dong ◽  
Fei Teng
Keyword(s):  
Acrylic Acid ◽  
Methyl Methacrylate ◽  
Acid Methyl ◽  
Hydroxypropyl Methacrylate ◽  
The Relationship

The copolymer had been synthesized by using N-tert-octylacrylamide/Acrylic acid/Methyl methacrylate/Butylaminoethyl Methacrylate/Hydroxypropyl Methacrylate as monomers.By adjusting monomers ratio,N-tert-octylacrylamide or methyl methacrylate,futher study the influence on the stiffness of the copolymer and the relationship beween monomers ratio and the stiffness.

scholarly journals Cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate) copolymer

2013 ◽  
pp. 2835 ◽  
Author(s):  
Ki-Choon Choi ◽  
Young-IL Jeong ◽  
Da Hye Kim ◽  
Kyungdong Lee ◽  
Gyuntaek Lim
Keyword(s):  
Acrylic Acid ◽  
Methyl Methacrylate ◽  
Methacrylate Copolymer ◽  
Poly Acrylic Acid

Synthesis of Poly(Octylacrylamide/Acrylic acid/Methyl methacrylate/Butylaminoethyl methacrylate/Hydroxypropyl methacrylate) and the Physical Properties of the Copolymer Films

2011 ◽  
Vol 396-398 ◽  
pp. 1217-1221
Author(s):  
Jie Zhu ◽  
Weng Fa Xiao ◽  
Li Tao Dong ◽  
Fei Teng
Keyword(s):  
Acrylic Acid ◽  
Tensile Test ◽  
Methyl Methacrylate ◽  
Physical Properties ◽  
Ammonium Persulfate ◽  
Copolymer Films ◽  
Acid Methyl ◽  
Hydroxypropyl Methacrylate ◽  
Sufficient Strength

the copolymer which as a hair fixing compositions was synthesized by using octyl-acrylamide,acrylicacid,methylmethacrylate,butylaminoethyl-methacrylate,hydroxypropyl methacrylate as monomers, and ammonium persulfate as initiator.The copolymer was charactered by IR .The tensile test and the elasticlty test were used to character the physical properties of the films of the copolymer which showed that the film had revealed excellent features such as sufficient strength and elasticity.

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