Vitamin D deficiency and depressive symptoms in pregnancy are associated with adverse perinatal outcomes

2018 ◽  
Vol 41 (5) ◽  
pp. 680-689 ◽  
Author(s):  
Eynav Elgavish Accortt ◽  
Amy Lamb ◽  
James Mirocha ◽  
Calvin J. Hobel
Keyword(s):  
Vitamin D ◽  
Depressive Symptoms ◽  
Vitamin D Deficiency ◽  
Perinatal Outcomes ◽  
Adverse Perinatal Outcomes ◽  
In Pregnancy

scholarly journals Adverse Perinatal Outcomes and Postpartum Multi-Systemic Dysregulation: Adding Vitamin D Deficiency to the Allostatic Load Index

2017 ◽  
Vol 21 (3) ◽  
pp. 398-406 ◽  
Author(s):  
Eynav Elgavish Accortt ◽  
James Mirocha ◽  
Christine Dunkel Schetter ◽  
Calvin J. Hobel
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Allostatic Load ◽  
Perinatal Outcomes ◽  
Adverse Perinatal Outcomes

scholarly journals High prevalence of vitamin D deficiency in pregnant women and its relationship with adverse pregnancy outcomes in Guizhou, China

2018 ◽  
Vol 46 (11) ◽  
pp. 4500-4505 ◽  
Author(s):  
Song Hong-Bi ◽  
Xu Yin ◽  
Yang Xiaowu ◽  
Wang Ying ◽  
Xu Yang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Perinatal Outcomes ◽  
Perinatal Period ◽  
Maternal Outcomes ◽  
Serum Vitamin D ◽  
Adverse Perinatal Outcomes ◽  
Adverse Pregnancy

Objective This study was performed to investigate the prevalence of vitamin D deficiency in pregnant women in Guizhou, China and its correlation with adverse infant and maternal outcomes during the perinatal period. Methods In total, 220 pregnant women who received perinatal care and delivered in the Affiliated Hospital of Guizhou Medical University from November 2014 to April 2015 were enrolled. Each woman’s serum vitamin D concentration was tested during early pregnancy, and its correlation with adverse infant and maternal outcomes in the perinatal period was analyzed. Results The mean serum vitamin D concentration was 29.5 ± 5.8 nmol/L. More than 90% of pregnant women had vitamin D insufficiency. Additionally, 38.4% of women with vitamin D deficiency and 22.2% with vitamin D inadequacy developed adverse perinatal outcomes. The vitamin D level was negatively correlated with adverse pregnancy outcomes. Conclusion Vitamin D deficiency is highly prevalent among pregnant women in Guizhou, China. The incidence of adverse perinatal outcomes was far higher in association with vitamin D deficiency than sufficiency. A negative correlation was found between the vitamin D level and the incidence of adverse perinatal outcomes in pregnant women. Therefore, targeted screening and proper supplementation are needed during early pregnancy.

scholarly journals Exploring the concept of functional vitamin D deficiency in pregnancy: impact of the interaction between 25-hydroxyvitamin D and parathyroid hormone on perinatal outcomes

2018 ◽  
Vol 108 (4) ◽  
pp. 821-829 ◽  
Author(s):  
Andrea Hemmingway ◽  
Louise C Kenny ◽  
Lucio Malvisi ◽  
Mairead E Kiely
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Vitamin D Deficiency ◽  
Gestational Hypertension ◽  
Reference Group ◽  
Geometric Mean ◽  
Perinatal Outcomes ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
In Pregnancy

AbstractBackgroundAssociations of vitamin D with perinatal outcomes are inconsistent and few studies have considered the wider calcium metabolic system.ObjectivesWe aimed to explore functional vitamin D deficiency in pregnancy by investigating associations between vitamin D status, parathyroid hormone (PTH), and perinatal outcomes.DesignSCOPE (Screening for Pregnancy Endpoints) Ireland is a prospective cohort study of low-risk, nulliparous pregnant women. We measured serum 25-hydroxyvitamin D [25(OH)D] and PTH at 15 wk of gestation in 1754 participants.ResultsMean ± SD 25(OH)D was 56.6 ± 25.8 nmol/L (22.7 ± 10.3 ng/mL) and geometric mean (95% CI) PTH was 7.84 pg/mL (7.7, 8.0 pg/mL) [0.86 pmol/L (0.85, 0.88 pmol/L)]. PTH was elevated in 34.3% of women who had 25(OH)D <30 nmol/L and in 13.9% of those with 25(OH)D ≥75 nmol/L. Whereas 17% had 25(OH)D <30 nmol/L, 5.5% had functional vitamin D deficiency, defined as 25(OH)D <30 nmol/L with elevated PTH. Elevated mean arterial pressure (MAP), gestational hypertension, pre-eclampsia, and small-for-gestational-age (SGA) birth were confirmed in 9.2%, 11.9%, 3.8%, and 10.6% of participants, respectively. In fully adjusted regression models, neither low 25(OH)D nor elevated PTH alone increased the risk of any individual outcome. The prevalence of elevated MAP (19.1% compared with 9.7%) and SGA (16.0% compared with 6.7%) were highest (P < 0.05) in those with functional vitamin D deficiency compared with the reference group [25(OH)D ≥75 nmol/L and normal PTH]. The adjusted prevalence ratio (PR) and RR (95% CIs) for elevated MAP and SGA were 1.83 (1.02, 3.27) and 1.53 (0.80, 2.93), respectively. There was no effect of functional vitamin D deficiency on the risk of gestational hypertension (adjusted RR: 1.00; 95% CI: 0.60, 1.67) or pre-eclampsia (adjusted RR: 1.17; 95% CI: 0.32, 4.20).ConclusionThe concept of functional vitamin D deficiency, reflecting calcium metabolic stress, should be considered in studies of vitamin D in pregnancy.The SCOPE pregnancy cohort is registered at http://www.anzctr.org.au as ACTRN12607000551493.

Improvement of Depressive Symptoms upon Correction of Vitamin D Deficiency in Women with Chronic Liver Disease

2015 ◽  
Vol 53 (01) ◽  
Author(s):  
CS Stokes ◽  
F Gruenhage ◽  
C Baus ◽  
M Riemenschneider ◽  
F Lammert
Keyword(s):  
Vitamin D ◽  
Depressive Symptoms ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Vitamin D Deficiency ◽  
Chronic Liver

Vitamin D3 and women's health

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (1) ◽  
pp. 44-51
Author(s):  
Iuliia E Dobrokhotova ◽  
Ekaterina I Borovkova ◽  
Sofya A Zalesskaya ◽  
Victoria S Skalnaya ◽  
Ivan M Borovkov ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Negative Impact ◽  
Perinatal Outcomes ◽  
Hypovitaminosis D ◽  
Malignant Neoplasms ◽  
Cellular Functions ◽  
Prophylactic Drug ◽  
Drug Doses

Background. Vitamin D is an essential component that regulates calcium homeostasis and many other cellular functions. Hypovitaminosis D is associated with a risk of osteopenia, obesity, type 1 and type 2 diabetes, malignant neoplasms and immune disorders. Inadequate vitamin D intake during pregnancy increases a risk of pre-eclampsia, preterm birth, low birth weight as well as it has a negative impact on both children’s and adolescents’ health. It is important for the clinician to be known administrating of vitamin D prophylactic and therapeutic regimens according to serum 25(OH)D levels. Aim. To determine causes and effects of vitamin D deficiency and to elaborate ways of their correction. Materials and methods. To write this review a search for domestic and foreign publications in Russian and international search systems (PubMed, eLibrary, etc.) for the last 2-15 years was conducted. The review includes articles from peer-reviewed literature. Results. The article shows that vitamin D has a significant impact on both the cardiovascular, endocrine, digestive, respiratory and other systems functioning and perinatal outcomes that necessitates vitamin D deficiency correction. It provides schemes for effective therapeutic and prophylactic drug doses calculating depending on vitamin D3 blood serum concentration. Conclusion. Preference should be given to cholecalciferol (vitamin D3) due to its better absorption properties and more efficient conversion to active vitamin metabolites (class IIC).

679: Vitamin D deficiency is common in pregnancy

2007 ◽  
Vol 197 (6) ◽  
pp. S194
Author(s):  
Donna Johnson ◽  
Carol Wagner ◽  
Myla Ebeling ◽  
Thomas Hulsey ◽  
Bruce Hollis
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
In Pregnancy

Should routine screening for vitamin D deficiency be performed in pregnancy?

2016 ◽  
Vol 19 (11) ◽  
pp. 8
Author(s):  
Charmaine Silveira Da Graca Costa ◽  
Kathryn Hoffmann
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Routine Screening ◽  
In Pregnancy

Adverse Perinatal Outcomes Associated with Stage 1 Hypertension in Pregnancy: A Retrospective Cohort Study

2021 ◽  
Author(s):  
Elizabeth Norton ◽  
Frances Shofer ◽  
Hannah Schwartz ◽  
Lorraine Dugoff
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort ◽  
Perinatal Outcomes ◽  
Hypertensive Disorder ◽  
Hypertension In Pregnancy ◽  
Increased Risk ◽  
Hypertensive Disorder Of Pregnancy ◽  
Adverse Perinatal Outcomes ◽  
Stage 1 ◽  
In Pregnancy

Objective To determine if women who newly met criteria for stage 1 hypertension in early pregnancy were at increased risk for adverse perinatal outcomes compared with normotensive women. Study Design We conducted a retrospective cohort study of women who had prenatal care at a single institution and subsequently delivered a live infant between December 2017 and August 2019. Women with a singleton gestation who had at least two prenatal visits prior to 20 weeks of gestation were included. We excluded women with known chronic hypertension or other major maternal illness. Two groups were identified: (1) women newly diagnosed with stage 1 hypertension before 20 weeks of gestation (blood pressure [BP] 130–139/80–89 on at least two occasions) and (2) women with no known history of hypertension and normal BP (<130/80 mm Hg) before 20 weeks of gestation. The primary outcome was any hypertensive disorder of pregnancy; secondary outcomes were indicated preterm birth and small for gestational age. Generalized linear models were used to compare risk of adverse outcomes between the groups. Results Of the 1,630 women included in the analysis, 1,443 women were normotensive prior to 20 weeks of gestation and 187 women (11.5%) identified with stage 1 hypertension. Women with stage 1 hypertension were at significantly increased risk for any hypertensive disorder of pregnancy (adjusted risk ratio [aRR]: 1.86, 95% confidence interval [CI]: 1.12–3.04) and indicated preterm birth (aRR: 1.83, 95% CI: 1.12–3.02). Black women and obese women with stage 1 hypertension were at increased for hypertensive disorder of pregnancy compared with white women and nonobese women, respectively (aRR: 1.32, 95% CI: 1.11–1.57; aRR: 1.69, 95% CI: 1.39–2.06). Conclusion These results provide insight about the prevalence of stage 1 hypertension and inform future guidelines for diagnosis and management of hypertension in pregnancy. Future research is needed to assess potential interventions to mitigate risk. Key Points

scholarly journals Association between Depressive Symptoms and Vitamin D Deficiency in Adults with Overweight or Obesity

2021 ◽  
Vol 19 (2) ◽  
pp. 55-63
Author(s):  
Hee Chan Chung ◽  
Young-Eun Jung ◽  
Chanwon Park ◽  
Moon-Doo Kim ◽  
Bo-Hyun Yoon
Keyword(s):  
Vitamin D ◽  
Depressive Symptoms ◽  
Vitamin D Deficiency ◽  
Overweight Or Obesity

Mild gestational hyperglycaemia as a risk factor for metabolic syndrome in pregnancy and adverse perinatal outcomes

2008 ◽  
Vol 24 (4) ◽  
pp. 324-330 ◽  
Author(s):  
Carlos Antonio Negrato ◽  
Lois Jovanovic ◽  
Marcos Antonio Tambascia ◽  
Iracema de Mattos Paranhos Calderon ◽  
Bruno Geloneze ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Perinatal Outcomes ◽  
Adverse Perinatal Outcomes ◽  
In Pregnancy
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