Guar Gum-Alginate Gel Coated Etherified Fenugreek Seed Mucilage-Alginate Microhybrids as Stomach-Targeting Flurbiprofen-Cargos

The mucilage (MMZ) extracted from the seeds of Manilkara zapota(Linn.) P. Royen syn. using maceration techniques was evaluated for mucoadhesive strength by various in vitro and in vivo methods. The result showed that mucoadhesive strength of seeds mucilage have comparable property toward natural and synthetic polymers such as Guar Gum and hydroxyl propyl methyl cellulose (HPMC E5LV) under the experimental conditions used in this study. Briefly, it could be concluded that the seed mucilage of Manilkara zapota can be used as a pharmaceutical excipient in oral mucoadhesive drug delivery systems. Further, it may be appropriate to study the changes in these properties after chemical modifications.

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Formulation and evaluation of fast dissolving tablets of amlodipine besylate by using Fenugreek seed mucilage and Ocimum basilicum gum

International Current Pharmaceutical Journal ◽

10.3329/icpj.v1i9.11614 ◽

2012 ◽

Vol 1 (9) ◽

pp. 243-249 ◽

Cited By ~ 4

Author(s):

Sudheshnababu Sukhavasi ◽

V. Sai Kishore

Keyword(s):

Drug Delivery ◽

Ocimum Basilicum ◽

Angle Of Repose ◽

Natural Polymers ◽

Amlodipine Besylate ◽

Disintegration Time ◽

Fenugreek Seed ◽

Wetting Time ◽

Seed Mucilage

Fast dissolving/disintegrating tablets have received ever-increasing demand during the last decade, and the field has became a rapidly growing area in the pharmaceutical area. Particularly the fast dissolving drug delivery systems formulated with natural polymers have more demand because natural materials like gums and mucilages have been extensively used in the field of drug delivery for their easy availability, ease administration, non toxicity, non irritant nature etc. The main aim of the present study was to formulate the fast dissolving tablets of amlodipine besylate tablets using Fenugreek seed mucilage and Ocimum basilicum gum as a natural superdisintegrating agents to achieve quick onset of action, is to increase the water uptake with in shortest wetting time and there by decrease the disintegration time of the tablets by simple and cost effective direct compression technique. Pre-compression parameters like angle of repose and post-compression parameters like wetting time, water absorption ratio, in-vitro disintegration and in-vitro dispersion time were studied. The hardness, friability and drug content of all the formulations were found to be within the limits. The best formulations FFGK5 & FOB5 have shown good disintegration time, hardness and friability. The best formulations were also found to be stable. Optimized formulation was subjected to stability studies as per ICH guidelines and it insignificant change in hardness, disintegration time and in vitro drug release.DOI: http://dx.doi.org/10.3329/icpj.v1i9.11614 International Current Pharmaceutical Journal 2012, 1(9): 243-249

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Bio-based Polymer Isolated from Seeds of Buchanania lanzan Spreng with Potential Use as Pharmaceutical Mucoadhesive Excipient

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2020.13.4.9 ◽

2020 ◽

Vol 13 (4) ◽

pp. 5028-5035

Author(s):

Sudarshan Singh ◽

Tanvi R Dodiya ◽

Sangeeta Singh ◽

Rajesh Dodiya ◽

Sunil B Bothara

Keyword(s):

Moisture Absorption ◽

Guar Gum ◽

Ex Vivo ◽

In Vivo Test ◽

Wetting Time ◽

Detachment Time ◽

Off Time ◽

Seed Mucilage

This study was aimed to develop an oral bio-based mucoadhesive polymer from seeds mucilage of Buchanania lanzan spreng, belongs to family anacardiaceae. Isolated mucilage was evaluated for mucoadhesive strength and compared with existing polymer. The mucilage showed shear stress results (0.099 ± 0.0001N), with comparable adhesiveness to methocel E5 (0.098 ± 0.0008N). Force of adhesion required to detach the seed mucilage and methocel E5 tablets from the mucin of intestinal tissue were 0.0276 ± 0.0019 (N) and 0.0049 ± 0.0006 (N), respectively. Seed mucilage revealed significant (P<0.01) higher detachment time, erosion time, in-vitro wash-off time and ex-vivo residence compared to methocel E5 and lactose tablets. In vivo test indicated that seed mucilage tablets possessed good mucoadhesive strength compared to methocel E5 and resisted disintegration for ≤ 8 h. The swelling index and wetting time showed comparable results between the mucilage and synthetic polymer tablets. Mucilage demonstrated high moisture absorption, percentage hydration, and matrix erosion of 18.57 ± 0.036, 50.00 ± 0.051, and 8.30 ± 0.155 compared to methocel E5 10.0 ± 0.079, 36.00 ± 0.089, and 1.26 ± 0.085, respectively. Mucoadhesive properties of seeds mucilage were comparable to guar gum and methocel E5, thus seed mucilage of B. lanzan can be potentially exploited for usage as a bioadhesive pharmaceutical excipient.

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