Analysis of blood serum of lung cancer patients using particle induced X-ray emission

1610 Background: Low dose computed tomography (LDCT) scans have reduced lung cancer deaths by 20.3% in high risk populations, although there is an unknown balance between the benefits and harms of LDCT scans as a screening tool. Our purpose was to compare health-related QOL issues among lung cancer patients who were initially detected by LDCT scans; 4 comparison groups included: lung cancer diagnosed by a screening chest X-ray, as an incidental finding from procedures taken for other medical reasons, or based on symptoms indicative for lung cancer and routinely diagnosed, and individuals who were LDCT screened but found no lung cancer (controls who participated in Mayo’s lung cancer CT screening trial). Methods: A total of 1,658 lung cancer patients (cared at Mayo Clinic) in the 4 groups (37, 151, 389, and 1081 respectively) and 488 controls were compared on following patient-reported outcomes (collected via validated tools): overall QOL, four symptoms (cough, pain, dyspnea, fatigue), mental/ physical/ emotional/ social/ spiritual QOL, and other concerns (e.g., family/ friends/ financial/ legal). A clinically significant deficit was defined as at least 10-points in difference (or <50 points) on a 0-100 scale. The rates of deficits were compared via Fisher’s exact tests and average QOL values via Kruskal-Wallis tests. Results: Overall QOL and individual symptoms were significantly worse (p<0.05) in all lung cancer groups than in controls, except for pain. LDCT-screened patients reported the greatest deficit among the 4 lung cancer groups in physical (41%), emotional (24%), social (38%), and spiritual QOL (24%); whereas chest X-ray detected patients had the least deficit in overall QOL (22%) and pain (32%). All 4 lung cancer groups experienced much worse fatigue (52-64%) than the controls (32%). Conclusions: Our preliminary results suggest that LDCT-screening detected lung cancer patients reported a different QOL profile from other lung cancer patients and non-lung cancer controls. The clinical course, smoking behavior, and QOL related health issues associated with LDCT screening for lung cancer warrant thorough investigation.

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THE STATE OF BONE METABOLISM IN LUNG CANCER PATIENTS

Experimental Oncology ◽

10.31768/2312-8852.2018.40(2):136-139 ◽

2018 ◽

Vol 40 (2) ◽

pp. 136-139 ◽

Cited By ~ 3

Author(s):

Y V Dumanskiy ◽

O V Syniachenko ◽

Ph A Stepko ◽

G S Taktashov ◽

O Y Chernyshova ◽

...

Keyword(s):

Lung Cancer ◽

Bone Metabolism ◽

Cancer Patients ◽

Chemical Elements ◽

Proximal Part ◽

Blood Levels ◽

X Ray ◽

Lung Cancer Patients ◽

The Status ◽

Calcium Magnesium

In recent years, we have discussed the correlation of malignant tumor process with the development of osteoporosis, which can be exacerbated by ongoing chemotherapy and radiation therapy. The aim of the work was to assess the status of bone metabolism in 32 untreated patients with lung cancer without metastasis. Materials and Methods: Patients underwent dual-energy X-ray osteodensitometry of proximal part of femoral bone. Osteopontin (OP), osteocalcin (OC) and alkaline phosphatase (AP) parameters were studied in blood, as well as osteo-associated chemical elements. Results: Lung cancer proceeds with severe disorders of bone metabolism, which is accompanied by an increase in blood levels of OP, OС, AP, phosphorus, lithium, lead, strontium and cobalt against a decrease of calcium, magnesium and manganese, which were observed in 75; 78; 31; 100; 66; 47; 44; 3; 100; 100, and 6% of patients, respectively; such disorder was associated with a morphological variant of the tumor (cobalt) and stage of disease (calcium, magnesium, manganese, strontium), development of osteodeficit (OP, OC, AR, strontium, zinc). Osteodeficit in the form of osteopenia and osteoporosis is observed more common in women, in every second patient, and osteodensimetric T-score depends on the age of patients, directly correlates with the values of the OP and OC, and inversely — with a zincemia rate. Conclusions: The disorders of bone metabolism in patients with lung cancer indicate the need for the development of antiosteoporosis treatment for cancer patients.

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Evaluation of the Concentration of Ubiquitin C Protein (UBC) in Patients of Lung Cancer and Comparing with Healthy Subjects

Engineering and Technology Journal ◽

10.30684/etj.v38i2b.449 ◽

2020 ◽

Vol 38 (2B) ◽

pp. 61-65

Author(s):

Abbas A. Mohammed ◽

Saleen S. Abdulhadi

Keyword(s):

Lung Cancer ◽

Blood Serum ◽

Cancer Patients ◽

Normal Subjects ◽

P Value ◽

Cellular Functions ◽

C Protein ◽

Lung Cancer Patients ◽

Healthy Control ◽

The Mean

Ubiquitin protein has a conserved amino acid sequence, found in all eukaryotes and it is important in many of cellular functions .The increase or decrease in the ubiquitin level lead to causing many diseases including cancer .The aim of this study is to measure the concentration of ubiquitin c protein in blood serum of lung cancer patients and healthy control subjects by using ELISA technique. The Mean ± SD for ubiquitin c protein was (7.51 ± 5.76) in blood serum of the normal healthy subject and Std. Error mean was (1.82). While the Mean ± SD was (10.99 ± 4.56 ) for ubiquitin c protein in serum of lung cancer patients and Std. Error mean was (1.44) .The results showed no statistically significance the P value ( 0.15) between the protein concentration in the serum of patients with lung cancer compared to the serum concentration of healthy normal subjects.

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