Characterization of solid dispersions of a powerful statin using thermoanalytical techniques

2019 ◽  
Vol 138 (5) ◽  
pp. 3701-3714
Author(s):  
Karla Monik Alves da Silva ◽  
Fernando José de Lima Ramos Júnior ◽  
José Venâncio Chaves Júnior ◽  
Deysiane Oliveira Brandão ◽  
Taynara Batista Lins ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Thermoanalytical Techniques

Physicochemical Characterization of Solid Dispersions of Cefdinir with PVP K-30 and PEG 4000

2010 ◽  
Vol 3 (2) ◽  
pp. 948-956
Author(s):  
Kumar P ◽  
S Kumar ◽  
A Kumar ◽  
M Chander
Keyword(s):  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Drug Carriers ◽  
Dissolution Properties ◽  
Rate Of Dissolution ◽  
Peg 4000 ◽  
Release Studies ◽  
Crystalline Nature ◽  
Physical Mixtures

The purpose of this study was to prepare and characterize solid dispersions of the antibacterial agent Cefdinir with PEG 4000 and PVP K-30 with a view to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obtained showed that the rate of dissolution of Cefdinir was considerably improved when formulated in solid dispersions with PVP K-30 and PEG 4000 as compared with pure drug and physical mixtures. The results from XRD studies showed the transition of crystalline nature of drug to amorphous form, while FTIR studies demonstrated the absence of drug-carriers interaction.

Preparation and Characterization of Poloxamer 407 Solid Dispersions as an Alternative Strategy to Improve Benznidazole Bioperformance

2018 ◽  
Vol 107 (11) ◽  
pp. 2829-2836 ◽  
Author(s):  
Analía Simonazzi ◽  
Carolina Davies ◽  
Alicia G. Cid ◽  
Elio Gonzo ◽  
Luis Parada ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Alternative Strategy ◽  
Poloxamer 407

scholarly journals Solid-state characterization of Felodipine–Soluplus amorphous solid dispersions

2015 ◽  
Vol 42 (3) ◽  
pp. 485-496 ◽  
Author(s):  
Jiannan Lu ◽  
Kristina Cuellar ◽  
Nathan I. Hammer ◽  
Seongbong Jo ◽  
Andreas Gryczke ◽  
...  
Keyword(s):  
Solid State ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
Solid State Characterization

Multi-unit Controlled Release Systems of Nifedipine and Nifedipine:Pluronic® F-68 Solid Dispersions: Characterization of Release Mechanisms

2002 ◽  
Vol 28 (3) ◽  
pp. 275-285 ◽  
Author(s):  
Ketan A. Mehta ◽  
M. Serpil Kislalioglu ◽  
Wantanee Phuapradit ◽  
A. Waseem Malick ◽  
Navnit H. Shah
Keyword(s):  
Controlled Release ◽  
Solid Dispersions ◽  
Release Mechanisms
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