Effect of chronic administration of vitamin E on the hemopoietic system in hypercholesterolemia

The effect of daily administration of parathion and paraoxon on hepatic stores and plasma concentrations of vitamin E was studied in the immature male rat. Parathion or paraoxon (30 p.p.m.) was added to the daily diet of various groups of eight immature animals (70 to 90 g). Control groups received a basic rat diet. At intervals of 2, 4, and 8 weeks after the beginning of treatment, control and treated animals were killed. A significant decrease in the body weight of the treated animals was noticed during the first 2 weeks of treatment. Food intake, liver weight, and plasma and liver tocopherol concentrations were not modified throughout the experiments in treated animals by comparison with controls. A marked inhibition of brain acetylcholinesterase activity (81%) was observed after 1 week of treatment with either parathion or paraoxon. During the following weeks, a slight recovery of acetylcholinesterase activity was observed in the paraoxon-treated groups: indeed, the cholinesterase inhibition decreased from 81% to 67% after 8 weeks. With parathion-treated animals, the recovery was more pronounced as the cholinesterase inhibition decreased from 81% to 33% after 8 weeks. Additional experiments revealed that the metabolism of paraoxon or parathion by liver homogenates was not stimulated in chronically treated rats. Thus, chronic administration of paraoxon or parathion does not seem to interfere with liver and plasma levels of vitamin E.

Download Full-text

Chronic administration of vitamin E in type 2 diabetic Nigerians

Abia State University Medical Students Association Journal ◽

10.4314/asumsaj.v4i1.42558 ◽

2009 ◽

Vol 4 (1) ◽

Author(s):

IN Nweke ◽

S Chinenye ◽

AC Ojule

Keyword(s):

Vitamin E ◽

Chronic Administration ◽

Type 2 Diabetic

Download Full-text

Vitamin E improved redox homeostasis in heart and aorta of hypothyroid rats

Endocrine Regulations ◽

10.1515/enr-2017-0021 ◽

2017 ◽

Vol 51 (4) ◽

pp. 205-212 ◽

Cited By ~ 1

Author(s):

M. Hedayati ◽

S. Niazmand ◽

M. Hosseini ◽

Y. Baghcheghi ◽

F. Beheshti ◽

...

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

Tap Water ◽

Redox Homeostasis ◽

Chronic Administration ◽

Control Group ◽

Cardiac Tissues ◽

Water Group ◽

Total Thiol ◽

Antioxidant Defense Enzymes

Abstract Objectives. The objective of this study was to evaluate the effect of vitamin E on the oxidative stress parameters and antioxidant defense enzymes in the heart and aorta of 6-n-propylthiouracil (PTU)-induced hypothyroid rats. Methods. The animals were divided into 4 experimental groups: Group 1 (Euthyroid) received tap water, Group 2 (Hypothyroid) received 0.05 % of PTU in dissolved in their drinking water, Group 3 (PTU+Vit E) hypothyroid rats treated with vitamin E, and Group 4 (Euthyroid+Vit E). Vitamin E was injected daily (20 mg/kg) to groups 3 and 4 via daily gavage for 6 weeks. Malondialdehyde (MDA) levels, total thiol levels, and the activities of Cu, Zn-superoxide dismutase (SOD) and catalase (CAT) were evaluated in the aortic and cardiac tissues. Results. A significant decrease of thyroxine (T4) serum levels confirmed hypothyroidism in rats, which received PTU. The MDA level increased and total thiol level decreased in the hypothyroid group compared to control group (p<0.001). Th e activities of SOD and CAT significantly decreased in the hypothyroid rats in comparison to the control. Vitamin E treatment resulted in increased levels of total thiol, SOD, and CAT within aortic and cardiac tissues and decreased levels of MDA in comparison with the hypothyroid group (p<0.01−p<0.001). Conclusions. PTU-induced hypothyroidism resulted in oxidative stress. Chronic administration of vitamin E to hypothyroid rats decreased the oxidative stress markers in the aortic and cardiac tissues.

Download Full-text