Quantitative assessment of the influence of PPARG P12A polymorphism on gestational diabetes mellitus risk

2012 ◽  
Vol 40 (2) ◽  
pp. 811-817 ◽  
Author(s):  
Caiyan Wang ◽  
Xiaotian Li ◽  
Zirong Huang ◽  
Jinfeng Qian
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Quantitative Assessment ◽  
Diabetes Mellitus Risk

scholarly journals Evaluation of Gestational Diabetes Mellitus Risk in South Indian Women Based on MTHFR (C677T) and FVL (G1691A) Mutations

2015 ◽  
Vol 3 ◽  
Author(s):  
Imran Ali Khan ◽  
Noor Ahmad Shaik ◽  
Vasundhara Kamineni ◽  
Parveen Jahan ◽  
Qurratulain Hasan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Mthfr C677t ◽  
Indian Women ◽  
South Indian ◽  
Diabetes Mellitus Risk

scholarly journals Association between functional genetic variants in retinoid X receptor-α/γ and gestational diabetes mellitus risk in a southern Chinese population

2021 ◽  
Author(s):  
Xiang-yuan Yu ◽  
Liping Song ◽  
Hui-ting Zheng ◽  
Shu-dan Wei ◽  
Xiao-lan Wen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Genetic Variants ◽  
Multiple Testing ◽  
Genetic Model ◽  
Normal Glucose Tolerance ◽  
Retinoid X Receptor ◽  
Southern Chinese ◽  
Diabetes Mellitus Risk

To clarify the effect of retinoid X receptor-a/g (RXR-α/γ) genes functional genetic variants (RXR-α rs4842194 G>A, RXR-γ rs100537 A>G and rs2134095 T>C) on the risk of gestational diabetes mellitus (GDM), a case-control study with 573 GDM patients and 740 pregnant women with normal glucose tolerance was performed in Guangxi area of China. An odds ratio (OR) with its corresponding 95%CI was used to assess the strengths of the association between genetic variation and GDM. After adjustment of age and pre-BMI, the logistic regression analysis showed that the rs2134095 was significantly associated with GDM risk (CC vs. TT/TC: adjusted OR=0.71, 95%CI=0.56~0.90) in all subjects, and this result remained highly significant after Bonferroni’s correction for multiple testing (P=0.004). The stratified analysis showed that rs2134095 was significantly associated with the risk of GDM among age>30 years (adjusted OR=0.61, 95%CI=0.39~0.97), BMI>22 kg/m2 (adjusted OR=0.46, 95%CI= 0.30~0.70), SBP>120mmHg (adjusted OR=1.96, 95%CI= 1.14~3.36), HbA1c<6.5%(adjusted OR=1.41, 95%CI=1.11~1.78), TG≤1.7mmol/L(adjusted OR=2.57,95%CI=1.45~4.53), TC≤ 5.18mmol/L (adjusted OR=1.58, 95%CI=1.13~2.22), HDL-c≤1.5mmol/L(adjusted OR=1.70, 95%CI= 1.16~2.49) and LDL-c> 3.12 mmol/L(adjusted OR= 1.47, 95%CI= 1.08~2.00) subjects, under the recessive genetic model. We also found that rs2134095 interacted with age (Pinteraction=0.039), pre-BMI (Pinteraction=0.040) and TG (Pinteraction=0.025) influencing individual's genetic susceptibility to GDM. The rs2134095 T>C is significantly associated with the risk of GDM by effect of a single locus and / or complex joint gene-gene and gene-environment interactions. Larger sample-size and different population studies are required to confirm the findings.

Antenatal inflammation and gestational diabetes mellitus risk among pregnant African-American women

2016 ◽  
Vol 115 ◽  
pp. 1-5 ◽  
Author(s):  
Andrew S Bossick ◽  
Rosalind M Peters ◽  
Charlotte Burmeister ◽  
Naveen Kakumanu ◽  
Jessica E Shill ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
African American ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
African American Women ◽  
American Women ◽  
Diabetes Mellitus Risk

scholarly journals Association of rs10830962 polymorphism with gestational diabetes mellitus risk in a Chinese population

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Kaipeng Xie ◽  
Ting Chen ◽  
Yue Zhang ◽  
Juan Wen ◽  
Xianwei Cui ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Chinese Population ◽  
Diabetes Mellitus Risk

scholarly journals Maternal asthma and gestational diabetes mellitus: Exploration of potential associations

2020 ◽  
pp. 1753495X2092679
Author(s):  
ME Jensen ◽  
HL Barrett ◽  
MJ Peek ◽  
PG Gibson ◽  
VE Murphy
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Asthma Management ◽  
Perinatal Outcomes ◽  
Mechanistic Studies ◽  
Vitamin D Levels ◽  
Underlying Mechanisms ◽  
Diabetes Mellitus Risk ◽  
Shared Risk

Asthma and gestational diabetes mellitus are prevalent during pregnancy and associated with adverse perinatal outcomes. The risk of gestational diabetes mellitus is increased with asthma, and more severe asthma; yet, the underlying mechanisms are unknown. This review examines existing literature to explore possible links.  Asthma and gestational diabetes mellitus are associated with obesity, excess gestational weight gain, altered adipokine levels and low vitamin D levels; yet, it’s unclear if these underpin the gestational diabetes mellitus–asthma association. Active antenatal asthma management reportedly mitigates asthma-associated gestational diabetes mellitus risk. However, mechanistic studies are lacking.  Existing research suggests asthma management during pregnancy influences gestational diabetes mellitus risk; this may have important implications for future antenatal strategies to improve maternal-fetal outcomes by addressing both conditions. Addressing shared risk factors, as part of antenatal care, may also improve outcomes. Finally, mechanistic studies, to establish the underlying pathophysiology linking asthma and gestational diabetes mellitus, could uncover new treatment approaches to optimise maternal and child health outcomes.

scholarly journals Research of gestational diabetes mellitus risk evaluation method

2016 ◽  
Vol 24 (s2) ◽  
pp. S499-S503
Author(s):  
Zhenyu Chi ◽  
Song Zhang ◽  
Yang Wang ◽  
Lin Yang ◽  
Yimin Yang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Risk Evaluation ◽  
Evaluation Method ◽  
Diabetes Mellitus Risk
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