In-vitro free radical scavenging activity of biosynthesized gold and silver nanoparticles using Prunus armeniaca (apricot) fruit extract

2012 ◽  
Vol 15 (1) ◽  
Author(s):  
Preeti Dauthal ◽  
Mausumi Mukhopadhyay
2014 ◽  
Vol 21 (6) ◽  
pp. 453-458 ◽  
Author(s):  
Duraisamy Gomathi ◽  
Ganesan Ravikumar ◽  
Manokaran Kalaiselvi ◽  
Balasubramaniam Vidya ◽  
Chandrasekar Uma

2017 ◽  
Vol 9 (4) ◽  
pp. 615
Author(s):  
Mukesh Kumar Yadav ◽  
Santosh Kumar Singh ◽  
JS Tripathi ◽  
YB Tripathi

<p><em>Centella asiatica</em> also known as <em>mandukparni </em>or Indian pennywort or <em>jalbrahmi</em>, which has been used as a medicine in the Ayurveda from ancient times and mentioned in many classical texts of Ayurveda. <em>Centella asiatica</em> has long been used to improve memory and cognitive function.</p><p>The study aimed to identify the phytochemicals present in different solvent extracts of <em>Centella asiatica </em>(i.e. PECA- Petroleum ether extract of <em>C. asiatica, </em>CCA- Chloroform extract of <em>C. asiatica, </em>EACA- Ethyl acetate extract of <em>C. asiatica,</em> ECA- Ethanolic extract of <em>C. asiatica, </em>HACA- Hydro-alcoholic extract of <em>C. asiatica</em>)<em> </em>and evaluate the respective in-vitro antioxidant potentials. <em></em></p><p>The phytochemical screening of extracts was done with standardized procedures and the antioxidant potential of different solvent extracts of <em>Centella asiatica</em> was assessed by its free radical scavenging activity 2, 2-diphenyl -1- picrylhydrazyl (DPPH) as well as hydrogen peroxide scavenging assay respectively for reducing capability.</p><p>In all different solvent extracts of <em>C. asiatica</em> revealed excellent free radical scavenging activity as revealed by 2-2- diphenyl-1-picryl-hydrazyl (DPPH) assay with  EC<sub>50</sub> values for ECA=128.752±1.85 μg/ml, HACA=274.884±1.21 μg/ml and hydrogen peroxide assay against the standard (Butylated hydroxytoluene) BHT, with the EC<sub>50</sub> values ECA=429.69±0.92 μg/ml HACA=458.08±0.58 μg/ml while rest solvent extracts shown very less antioxidant activity.</p><p> The present study indicates that the <em>Centella asiatica</em> extracts have good antioxidant activity which can be used in stress and anxiety and also a good source to be used as natural drugs.</p>


Author(s):  
Md Raihan Sarkar ◽  
Moynul Hasan ◽  
Md Sariful Islam Howlader ◽  
Mohammad Saydur Rahman ◽  
Shubhra Kanti Dey

In the present study, the antioxidant and analgesic potential of the ethanolic extract of the leaves of Derris trifoliata was evaluated. The free radical scavenging activity of the crude extract on the stable radical 1, 1-diphenyl-2-picrylhydrazyl (DPPH) was determined by comparing the DPPH inhibitory capacity of the extract. In the quantitative assay, Derris trifoliata extract displayed a free radical scavenging activity in the DPPH assay (IC50 = 19 ?g/ml) which is comparable to that of ascorbic acid (IC50 = 7.80 ?g/ml), a well-known standard antioxidant. The analgesic responses of the given samples of extracts were evaluated using the Tail immersion method. In the analgesic activity test, extract at dose of 200 mg/kg and 400 mg/kg exhibited significant (P<0.05 and P<0.001 respectively) inhibition of pain by 166.82 and 184.95 after 120 and 180 minutes respectively while the standard drug Diclofenac Na inhibition was found to be 217.67 after 180 minutes at a dose of 25 mg/kg body weight DOI: http://dx.doi.org/10.3329/ijpls.v1i2.12951 International Journal of Pharmaceutical and Life Sciences Vol.1(2) 2012


2012 ◽  
Vol 90 (8) ◽  
pp. 652-659 ◽  
Author(s):  
Sabine Montaut ◽  
Julie Grandbois ◽  
Laura S. Rossi ◽  
Sonia Kamal ◽  
James Khouri ◽  
...  

Glucolesquerellin (2), glucohesperin (3), quercetin 3-O-sophoroside (4), and quercetin 3-O-sophoroside-7-O-glucoside (5), isolated from the fruit of Dithyrea wislizenii , were quantified by HPLC. The fruit extract and flavonoids were not found to be toxic by using a brine shrimp lethality assay. The fruit extract and the flavonoids and glucosinolates were submitted to a free-radical scavenging activity assay with the diphenylpicrylhydrazyl radical (DPPH•). The concentration of quercetin (6) (a positive control for the flavonoids) able to scavenge 50% of DPPH• (SC50) was 32 ± 2 µmol/L (or 4 ± 1 µg/mL), which was about 27 times more potent than the crude extract. Compounds 4 and 5 had a SC50, the concentration of the compound required to scavenge 50% of the DPPH•, of 78 ± 1 µmol/L and 113 ± 10 µmol/L, respectively. The positive control for the glucosinolates, glucoraphasatin, (1) had a SC50 of 1768 ± 60 µmol/L. The glucosinolates 2 and 3 had a SC50 of 7819 ± 1968 and 970 ± 63 µmol/L, respectively.


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