Kindling in the early postnatal period: Effects on the dynamics of age-related changes in electrophysiological characteristics of hippocampal neurons

Annotation. The purpose is сlarification of patterns of age-related changes in the activity of aspartate aminotransferase (AsAT), alanine aminotransferase (AlAT), gamma-glutamyltransferase (GGT), α-amylase, alkaline phosphatase (AlP) and acid phosphatase (AP ) in tissues of different parts of the cecum in piglets of large white breed, in different phases of nutrition of the early postnatal period of systemic genesis of pig. Methods. Enzyme activities were determined spectrophotometrically (UV-1800) and using a set of reagents from the OJSC Vital Development Corporation, St. Petersburg. The activity of the enzymes AsAT and AlAT was determined by the method of Wrightman and Frenkel, GGT – by the unified colorimetric method at the “end point”. The α-amylase activity was measured by the method of Karavei. The level of AP, AlP was determined by the Bessey – Lowry – Brock method. Results. The degree of structural and chemical changes in the tissues of the cecum in piglets is high in the early phases of the postnatal period, during the first four months of life. They are especially pronounced in transitional phases of nutrition. The most intense age-related changes in metabolic processes in the tissues of the cecum in piglets were revealed between the milk and colostrum and first milk, between the first and second milk, between the third milk and milk-definitive, as well as between the first and second definitive phases. The timing of stabilization of the activity of individual enzymes in the tissues of the cecum is determined. They are detected in piglets in the later phases of feeding. The scientific novelty of the study lies in the fact that the nature and intensity of age-related changes in the activity of aspartate and alanine aminotransferases, gamma-glutamyl transferase, α-amylase, acidic and alkaline phosphatases in tissues of different parts of the cecum in growing piglets were revealed.

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ACTIVITY OF ASPARTATE AMINOTRANSFERASE IN THE TISSUES OF THE DUODENUM IN RABBITSIN DIFFERENT PHASES OF POSTNATAL ONTOGENESIS

Bulletin Samara State Agricultural Academy ◽

10.12737/19065 ◽

2016 ◽

Vol 1 (2) ◽

pp. 75-78

Author(s):

Терентьева ◽

Mayya Terenteva ◽

Мардарьева ◽

Nataliya Mardareva

Keyword(s):

Aspartate Aminotransferase ◽

Age Groups ◽

Muscle Layer ◽

Postnatal Period ◽

Postnatal Ontogenesis ◽

Postnatal Life ◽

Second Phase ◽

Age Related ◽

And Function ◽

Age Related Changes

The purpose of the study is improving different body systems of animals in separate development phases of postnatal ontogenesis. To achieve this goal we studied the patterns of age-related changes of the activity of aspartate aminotransferase in the tissues of the duodenum of rabbits in different phases. Used rabbits breed gray giant at the age 1, 6, 12, 18, 24, 30, 45, 60, 90 and 120 days. The duodenum was divided into three parts: proximal, medial and distal. In every part of the duodenum was isolated two layers: mucous and muscle. In their studies of early postnatal life of rabbits was divided into phases. The studies show that due to changes in the structure and function of the muscular and mucous layers of the mucous membrane of the duodenum, due to changes in the composition and amount of food the activity of the enzyme varies. The activity of AST in the tissues of the mucous and muscle layers of the proximal, medial and distal parts of the duodenum at the age 1 day of rabbits in the colostrum nutrition phase, compared with other age groups, relatively low. In the first six days of life, in colostrum nutrition phase, the enzyme activity increases significantly. To twelve daily age rabbits, in the first dairy feeding phase, the activity of AST also increased significantly. Subsequently, the daily age of eighteen, in the second phase of dairy feeding, the activity of AST decreased significantly in the tissues of both layers ofthe proximal, medial and distal parts of the duodenum. Fromthedailyage of eighteen of rabbits in the tissues mucous layer of the proximal, medial and distal parts and in muscle layer of the distal part of the duodenum, the activity of AST is stabilized. In the muscle layer of the proximal and medial parts of the gut in subsequent phases of feeding rabbits the nature and intensity of age-related changes in activity of AST are slightly different. These distinctive features in the muscle layer of the mentioned parts of the duodenum, possibly associated with peculiarities of generation of their structure. Thus, the most intensive processes of transamination of aminoacids with the participation of aspartate aminotransferase in the examined tissues are seen in rabbits at early stages of postnatal period, toeighteendayold.

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Age-related changes in expression of ampa-selective glutamate receptor subunits: Is calcium-permeability altered in hippocampal neurons?

Neuroscience ◽

10.1016/0306-4522(94)90422-7 ◽

1994 ◽

Vol 61 (3) ◽

pp. 429-433 ◽

Cited By ~ 51

Author(s):

S.R. Pagliusi ◽

P. Gerrard ◽

M. Abdallah ◽

D. Talabot ◽

S. Catsicas

Keyword(s):

Glutamate Receptor ◽

Hippocampal Neurons ◽

Age Related ◽

Calcium Permeability ◽

Age Related Changes

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3PT217 Age-related changes in spine density and morphology of hippocampal neurons in relation to memory impairment(The 50th Annual Meeting of the Biophysical Society of Japan)

Seibutsu Butsuri ◽

10.2142/biophys.52.s177_5 ◽

2012 ◽

Vol 52 (supplement) ◽

pp. S177-S178

Author(s):

Suguru Kawato ◽

Koren Li ◽

Yasushi Hojo

Keyword(s):

Annual Meeting ◽

Hippocampal Neurons ◽

Memory Impairment ◽

Spine Density ◽

Age Related ◽

Biophysical Society ◽

Age Related Changes

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Features of growth and development of the skeleton in Simmental and crossbred steers during ontogenesis

Glavnyj zootehnik (Head of Animal Breeding) ◽

10.33920/sel-03-2109-04 ◽

2021 ◽

pp. 28-36

Author(s):

I. P. Prokhorov ◽

A. N. Pikul ◽

V. N. Lukyanov ◽

O. A. Kalmykova

Keyword(s):

Growth Rate ◽

Growth And Development ◽

Bone Growth ◽

Postnatal Period ◽

Control Group ◽

Lower Growth ◽

Age Related ◽

Axial Part ◽

Lower Growth Rate ◽

Age Related Changes

The results of age-related changes in the morphological composition of carcasses, features of growth and development of the axial and peripheral parts of the skeleton, and their constituent bones, Simmental and crossbred steers have been presented in the paper. The purpose of the research was to study the features of growth and development of the skeleton of Simmental and crossbred steers. The research has been carried out on the basis of the Tula Scientific and Research Institute of Agriculture – a branch of the Federal Research Center “Nemchinovka”. In order to conduct experiments 3 groups of steers have been formed per 15 heads in each with using the method of analogous pairs. Animals of Simmental breed were included in the 1st control group, and in the 2nd and 3rd experimental groups consist of 1/2-blood steers of beef Simmental and Charollais breeds, respectively, obtained from crossbreeding Simmental cows with sires of these beef breeds. The experiment lasted until the 18-month-old of steers. It has been found that the intensity of bone growth in the axial and peripheral parts of the skeleton was due to age-related changes in the absolute and relative bone mass of steers. The intensity of growth of the axial part of the skeleton in the postnatal period increased, and the peripheral decreased. The ribs and spine were characterized by the increased growth rate, while the thoracic and pelvic limbs were characterized by the lower growth rate. The intensity of bone growth in the proximal parts of the limbs exceeded that of the distal parts. Age-related differences in the intensity of growth of the skeletal parts led to changes in the ratio between the linear body size and the features of the steers’ constitution. The value of the long-legness indices in Charolais crossbreds decreased from 65,4 at birth to 53,6 and 46,6 at the age of 6 and 12 months, respectively, while the lengthiness indices on the contrary increased and in these age periods amounted to 93,4, 105,4 and 114,9, respectively.

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