Protective Effect of Mild Hypothermia on Spinal Cord Ischemia-Induced Delayed Paralysis and Spinal Cord Injury

2022 ◽  
Author(s):  
Dan Fu ◽  
Cai Chen ◽  
Liang He ◽  
Jingjuan Li ◽  
Aiguo Li
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Protective Effect ◽  
Mild Hypothermia ◽  
Spinal Cord Ischemia ◽  
Cord Injury

Neuroprotective Effect of Epidural Electrical Stimulation against Ischemic Spinal Cord Injury in Rats

2005 ◽  
Vol 103 (1) ◽  
pp. 84-92 ◽  
Author(s):  
Manabu Kakinohana ◽  
Hideki Harada ◽  
Yasunori Mishima ◽  
Tatsuhiko Kano ◽  
Kazuhiro Sugahara
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Electrical Stimulation ◽  
Neuroprotective Effect ◽  
Spinal Cord Ischemia ◽  
Aortic Occlusion ◽  
Cord Injury ◽  
Optimal Setting ◽  
Transient Aortic Occlusion ◽  
Ischemic Spinal Cord Injury

Background Electroconvulsion therapy is likely to serve as an effective preconditioning stimulus for inducing tolerance to ischemic brain injury. The current study examines whether electrical stimuli on the spinal cord is also capable of inducing tolerance to ischemic spinal cord injury by transient aortic occlusion. Methods Spinal cord ischemia was induced by occlusion of the descending thoracic aorta in combination with maintaining systemic hypotension (40 mmHg) during the procedure. Animals implanted with epidural electrodes were divided into four groups according to electrical stimulation and sham. Two groups consisted of rapid preconditioning (RE group, n = 8) and sham procedure (RC group, n = 8) 30 min before 9 min of spinal cord ischemia. In the two groups that underwent delayed preconditioning, rats were exposed to 9 min of aortic occlusion 24 h after either pretreatment with epidural electrical stimulation (DE group, n = 8) or sham (DC group, n = 8). In addition, rats were exposed to 6-11 min of spinal cord ischemia at 30 min or 24 h after epidural electrical stimulation or sham stimulation. The group P50 represents the duration of spinal cord ischemia associated with 50% probability of resultant paraplegia. Results Pretreatment with electrical stimulation in the DE group but not the RE group protected the spinal cord against ischemia, and this stimulation prolonged the P50 by approximately 15.0% in the DE group compared with the DC group. Conclusions Although the optimal setting for this electrical preconditioning should be determined in future studies, the results suggest that epidural electrical stimulation will be a useful approach to provide spinal protection against ischemia.

scholarly journals The protective effect of microRNA-21 in neurons after spinal cord injury

Spinal Cord ◽  
2018 ◽  
Vol 57 (2) ◽  
pp. 141-149 ◽  
Author(s):  
Tao Zhang ◽  
Shuangfei Ni ◽  
Zixiang Luo ◽  
Ye Lang ◽  
Jianzhong Hu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Protective Effect ◽  
Cord Injury

Protective effect of Oxymatrine against acute spinal cord injury in rats via modulating oxidative stress, inflammation and apoptosis

2019 ◽  
Vol 35 (1) ◽  
pp. 149-157
Author(s):  
Binggang Guan ◽  
Rongchun Chen ◽  
Mingliang Zhong ◽  
Ning Liu ◽  
Qin Chen
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Protective Effect ◽  
Acute Spinal Cord Injury ◽  
Cord Injury

Sublethal concentration of H2O2 enhances the protective effect of mesenchymal stem cells in rat model of spinal cord injury

2017 ◽  
Vol 40 (3) ◽  
pp. 609-615 ◽  
Author(s):  
Asrin Rahimi ◽  
Iraj Amiri ◽  
Amaneh Mohammadi Roushandeh ◽  
Zoleikha Golipour Choshali ◽  
Zohreh Alizadeh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Protective Effect ◽  
Rat Model ◽  
Sublethal Concentration ◽  
Cord Injury
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