Multicomponent Amorphous Nanofibers Electrospun from Hot Aqueous Solutions of a Poorly Soluble Drug

2010 ◽  
Vol 27 (11) ◽  
pp. 2466-2477 ◽  
Author(s):  
Deng-Guang Yu ◽  
Li-Dong Gao ◽  
Kenneth White ◽  
Christopher Branford-White ◽  
Wei-Yue Lu ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Studies on the Preparation, Characterization and Solubility of -Cyclodextrin-Roxythromycin Inclusion Complexes

2009 ◽  
Vol 2 (2) ◽  
pp. 523-530
Author(s):  
D. Nagasamy Venkatesh ◽  
S. Karthick ◽  
M. Umesh ◽  
G. Vivek ◽  
R.M. Valliappan ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Inclusion Complexes ◽  
Phase Solubility ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Ir Studies ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Roxythromycin/ β-cyclodextrin (Roxy/ β-CD) dispersions were prepared with a view to study the influence of β-CD on the solubility and dissolution rate of this poorly soluble drug. Phase-solubility profile indicated that the solubility of roxythromycin was significantly increased in the presence of β-cyclodextrin and was classified as AL-type, indicating the 1:1 stoichiometric inclusion complexes. Physical characterization of the prepared systems was carried out by differential scanning calorimetry (DSC), X-ray diffraction studies (XRD) and IR studies. Solid state characterization of the drug β-CD binary system using XRD, FTIR and DSC revealed distinct loss of drug crystallinity in the formulation, ostensibly accounting for enhancement of dissolution rate.

Impact of Drug-Polymer Interaction in Amorphous Solid Dispersion Aiming for the Supersaturation of Poorly Soluble Drug in Biorelevant Medium

2020 ◽  
Vol 21 (5) ◽  
Author(s):  
Cassiana Mendes ◽  
Rafael G. Andrzejewski ◽  
Juliana M. O. Pinto ◽  
Leice M. R. de Novais ◽  
Andersson Barison ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion ◽  
Poorly Soluble ◽  
Poorly Soluble Drug ◽  
Drug Polymer Interaction ◽  
Biorelevant Medium ◽  
Polymer Interaction

scholarly journals Stabilisation of Lutein and Lutein Esters with Polyoxyethylene Sorbitan Monooleate, Medium-Chain Triglyceride Oil and Lecithin

Foods ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 500
Author(s):  
Zala Gombač ◽  
Ilja Gasan Osojnik Črnivec ◽  
Mihaela Skrt ◽  
Katja Istenič ◽  
Andreja Knez Knafelj ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Medium Chain Triglyceride ◽  
Storage Conditions ◽  
Sorbitan Monooleate ◽  
Medium Chain ◽  
Poorly Soluble

Lutein is a challenging compound to incorporate into food, as it is poorly soluble and unstable in aqueous solutions. In this study, the aim was to prepare stable encapsulates of lutein and lutein esters using feasible and straightforward techniques. Fine suspensions based on polyoxyethylene sorbitan monooleate and medium-chain triglyceride oil micelle-like units with 3.45% lutein esters or 1.9% lutein equivalents provided high encapsulation efficiencies of 79% and 83%, respectively. Lutein encapsulated in fine suspensions showed superior stability, as 86% was retained within the formulation over 250 days at 25 °C in the dark. Under the same storage conditions, only 38% of lutein remained in corresponding formulations. Higher encapsulation efficiencies were achieved with lecithin emulsions, at up to 99.3% for formulations with lutein, and up to 91.4% with lutein esters. In lecithin emulsions that were stored for 250 days, 17% and 80% of lutein and lutein esters, respectively, were retained within the formulations.

In vitro models to evaluate the permeability of poorly soluble drug entities: Challenges and perspectives

2012 ◽  
Vol 45 (3) ◽  
pp. 235-250 ◽  
Author(s):  
Stephen T. Buckley ◽  
Sarah M. Fischer ◽  
Gert Fricker ◽  
Martin Brandl
Keyword(s):  
In Vitro Models ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Solubilization behavior of a poorly soluble drug under combined use of surfactants and cosolvents

2006 ◽  
Vol 28 (1-2) ◽  
pp. 7-14 ◽  
Author(s):  
Kohsaku Kawakami ◽  
Naohiko Oda ◽  
Kyoko Miyoshi ◽  
Takeshi Funaki ◽  
Yasuo Ida
Keyword(s):  
Combined Use ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Investigating the solubilization effect of oxcarbazepine by forming cocrystals

CrystEngComm ◽  
2019 ◽  
Vol 21 (32) ◽  
pp. 4718-4729
Author(s):  
Xiangrong Li ◽  
Guojia Yu ◽  
Xinjian Chen ◽  
Lichao He ◽  
Zhiyong Zhou ◽  
...  
Keyword(s):  
Poorly Soluble ◽  
Poorly Soluble Drug

Oxcarbazepine (OXCBZ) is a poorly soluble drug that can't form a salt. The apparent solubilities of the OXCBZ–OA and OXCBZ–2,5-DHBA cocrystals increased approximately 2.6 and 4.7 times of that of OXCBZ.

scholarly journals Transmission Electron Microscopy of a Poorly Soluble Drug, Felodipine

2016 ◽  
pp. 720-721
Author(s):  
Mark S'ari ◽  
James Cattle ◽  
Andy Brown ◽  
Brydson Rik ◽  
Nicole Hondow ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Transmission Electron ◽  
Poorly Soluble ◽  
Poorly Soluble Drug
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