scholarly journals Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications

2010 ◽  
Vol 11 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Corey E. Tabit ◽  
William B. Chung ◽  
Naomi M. Hamburg ◽  
Joseph A. Vita
Keyword(s):  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Molecular Mechanisms ◽  
Clinical Implications

Endothelial Dysfunction: From Molecular Mechanisms to Measurement, Clinical Implications, and Therapeutic Opportunities

2008 ◽  
Vol 10 (9) ◽  
pp. 1631-1674 ◽  
Author(s):  
Michelle Le Brocq ◽  
Stephen J. Leslie ◽  
Philip Milliken ◽  
Ian L. Megson
Keyword(s):  
Endothelial Dysfunction ◽  
Molecular Mechanisms ◽  
Clinical Implications

scholarly journals The Main Determinants of Diabetes Mellitus Vascular Complications: Endothelial Dysfunction and Platelet Hyperaggregation

2018 ◽  
Vol 19 (10) ◽  
pp. 2968 ◽  
Author(s):  
Albino Carrizzo ◽  
Carmine Izzo ◽  
Marco Oliveti ◽  
Antonia Alfano ◽  
Nicola Virtuoso ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Molecular Mechanisms ◽  
Vascular Complications ◽  
World Health ◽  
Northern Europe ◽  
Common Disease ◽  
Main Determinants ◽  
Health Organization ◽  
Platelet Hyperaggregation

Diabetes mellitus is a common disease that affects 3–5% of the general population in Italy. In some countries of northern Europe or in North America, it can even affect 6–8% of the population. Of great concern is that the number of cases of diabetes is constantly increasing, probably due to the increase in obesity and the sedentary nature of the population. According to the World Health Organization, in the year 2030 there will be 360 million people with diabetes, compared to 170 million in 2000. This has important repercussions on the lives of patients and their families, and on health systems that offer assistance to patients. In this review, we try to describe in an organized way the pathophysiological continuity between diabetes mellitus, endothelial dysfunction, and platelet hyperaggregation, highlighting the main molecular mechanisms involved and the interconnections.

Insulin Resistance the Link between T2DM and CVD: Basic Mechanisms and Clinical Implications

2019 ◽  
Vol 17 (2) ◽  
pp. 153-163 ◽  
Author(s):  
Muhammad A. Abdul-Ghani ◽  
Amin Jayyousi ◽  
Ralph A. DeFronzo ◽  
Nidal Asaad ◽  
Jassim Al-Suwaidi
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Molecular Mechanisms ◽  
Clinical Implications ◽  
Metabolic Abnormalities ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Cardinal Feature

Insulin resistance (IR) is a cardinal feature of type 2 diabetes mellitus (T2DM). It also is associated with multiple metabolic abnormalities which are known cardiovascular disease (CVD) risk factors. Thus, IR not only contributes to the development of hyperglycemia in T2DM patients, but also to the elevated CVD risk. Improving insulin sensitivity is anticipated to both lower the plasma glucose concentration and decrease CVD risk in T2DM patients, independent of glucose control. We review the molecular mechanisms and metabolic consequences of IR in T2DM patients and discuss the importance of addressing IR in the management of T2DM.

scholarly journals Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications

2015 ◽  
Vol 23 (1) ◽  
Author(s):  
Priyanga Ranasinghe ◽  
Shehani Pigera ◽  
Priyadarshani Galappatthy ◽  
Prasad Katulanda ◽  
Godwin R. Constantine
Keyword(s):  
Diabetes Mellitus ◽  
Molecular Mechanisms ◽  
Clinical Implications

scholarly journals The relationships among hyperuricemia, endothelial dysfunction, and cardiovascular diseases: Molecular mechanisms and clinical implications

2012 ◽  
Vol 59 (3) ◽  
pp. 235-242 ◽  
Author(s):  
Paolo Puddu ◽  
Giovanni M. Puddu ◽  
Eleonora Cravero ◽  
Luca Vizioli ◽  
Antonio Muscari
Keyword(s):  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
Molecular Mechanisms ◽  
Clinical Implications

The research of the molecular mechanisms of endothelial dysfunction in vitro

2019 ◽  
Vol XIV (1) ◽  
Author(s):  
R.E. Kalinin ◽  
I.A. Suchkov ◽  
N.V. Korotkova ◽  
N.D. Mzhavanadze
Keyword(s):  
Endothelial Dysfunction ◽  
Molecular Mechanisms

Role of Vitamin C in Endothelial Dysfunction in Patients with Type 2 Diabetes Mellitus Introduction

2020 ◽  
Vol 11 (2) ◽  
pp. 1701
Author(s):  
Nermien Abd El Rahman Ibraheim ◽  
Fatema El Zahraa Sayed Bukhary ◽  
Yehia Zakareia Mahmoud ◽  
Mahmoud Ragab Mohamed ◽  
Salama Rabei Abdel-Rahim
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Vitamin C

The 9p21 Locus and its Potential Role in Atherosclerosis Susceptibility; Molecular Mechanisms and Clinical Implications

2016 ◽  
Vol 22 (37) ◽  
pp. 5730-5737 ◽  
Author(s):  
Amir Tajbakhsh ◽  
Mohammad Khorrami ◽  
Seyed Hassanian ◽  
Malihe Aghasizade ◽  
Alireza Pasdar ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Potential Role ◽  
Clinical Implications ◽  
9P21 Locus

scholarly journals The Landscape of microRNAs in βCell: Between Phenotype Maintenance and Protection

2021 ◽  
Vol 22 (2) ◽  
pp. 803
Author(s):  
Giuseppina Emanuela Grieco ◽  
Noemi Brusco ◽  
Giada Licata ◽  
Daniela Fignani ◽  
Caterina Formichi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Disorders ◽  
Molecular Mechanisms ◽  
Β Cell ◽  
Physiological Mechanisms ◽  
Effective Strategies ◽  
Chronic Hyperglycaemia ◽  
Shed Light

Diabetes mellitus is a group of heterogeneous metabolic disorders characterized by chronic hyperglycaemia mainly due to pancreatic β cell death and/or dysfunction, caused by several types of stress such as glucotoxicity, lipotoxicity and inflammation. Different patho-physiological mechanisms driving β cell response to these stresses are tightly regulated by microRNAs (miRNAs), a class of negative regulators of gene expression, involved in pathogenic mechanisms occurring in diabetes and in its complications. In this review, we aim to shed light on the most important miRNAs regulating the maintenance and the robustness of β cell identity, as well as on those miRNAs involved in the pathogenesis of the two main forms of diabetes mellitus, i.e., type 1 and type 2 diabetes. Additionally, we acknowledge that the understanding of miRNAs-regulated molecular mechanisms is fundamental in order to develop specific and effective strategies based on miRNAs as therapeutic targets, employing innovative molecules.

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