scholarly journals Evaluating the Role of Amide Proton Transfer (APT)–Weighted Contrast, Optimized for Normalization and Region of Interest Selection, in Differentiation of Neoplastic and Infective Mass Lesions on 3T MRI

2019 ◽  
Vol 22 (2) ◽  
pp. 384-396 ◽  
Author(s):  
Ayan Debnath ◽  
Rakesh Kumar Gupta ◽  
Anup Singh
Keyword(s):  
Proton Transfer ◽  
Region Of Interest ◽  
Amide Proton ◽  
3T Mri ◽  
Amide Proton Transfer ◽  
Mass Lesions

Amide proton transfer (APT) imaging of brain tumors at 7 T: The role of tissue water T1-Relaxation properties

2016 ◽  
Vol 77 (4) ◽  
pp. 1525-1532 ◽  
Author(s):  
Vitaliy Khlebnikov ◽  
Daniel Polders ◽  
Jeroen Hendrikse ◽  
Pierre A. Robe ◽  
Eduard H. Voormolen ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Proton Transfer ◽  
Amide Proton ◽  
Tissue Water ◽  
Relaxation Properties ◽  
Amide Proton Transfer ◽  
Apt Imaging ◽  
T1 Relaxation

The role of amide proton transfer imaging in detecting active malignant glioma.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 2024-2024 ◽  
Author(s):  
J. O. Blakeley ◽  
X. Ye ◽  
M. Lim ◽  
H. Zhu ◽  
L. Blair ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Malignant Glioma ◽  
Amide Proton ◽  
Amide Proton Transfer ◽  
Amide Proton Transfer Imaging

scholarly journals Characterizing amide proton transfer imaging in haemorrhage brain lesions using 3T MRI

2016 ◽  
Vol 27 (4) ◽  
pp. 1577-1584 ◽  
Author(s):  
Ha-Kyu Jeong ◽  
Kyunghwa Han ◽  
Jinyuan Zhou ◽  
Yansong Zhao ◽  
Yoon Seong Choi ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Brain Lesions ◽  
Amide Proton ◽  
3T Mri ◽  
Amide Proton Transfer ◽  
Amide Proton Transfer Imaging

Role of Amide Proton Transfer (APT)-MRI of Endogenous Proteins and Peptides in Brain Tumor Imaging

2013 ◽  
pp. 171-181
Author(s):  
Silun Wang ◽  
Samson Jarso ◽  
Peter C. M. van Zijl ◽  
Jinyuan Zhou
Keyword(s):  
Brain Tumor ◽  
Proton Transfer ◽  
Tumor Imaging ◽  
Amide Proton ◽  
Amide Proton Transfer ◽  
Endogenous Proteins ◽  
Proteins And Peptides

Optimization of steady-state pulsed CEST imaging for amide proton transfer at 3T MRI

2019 ◽  
Vol 81 (6) ◽  
pp. 3616-3627 ◽  
Author(s):  
Byungjai Kim ◽  
Seohee So ◽  
Hyunwook Park
Keyword(s):  
Steady State ◽  
Proton Transfer ◽  
Amide Proton ◽  
3T Mri ◽  
Amide Proton Transfer ◽  
Cest Imaging

scholarly journals Amide proton transfer weighted (APTw) imaging based radiomics allows for the differentiation of gliomas from metastases

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elisabeth Sartoretti ◽  
Thomas Sartoretti ◽  
Michael Wyss ◽  
Carolin Reischauer ◽  
Luuk van Smoorenburg ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Brain Tumors ◽  
Proton Transfer ◽  
Multilayer Perceptron ◽  
Random Forest Classifier ◽  
Amide Proton ◽  
Low Grade ◽  
Who Grade ◽  
Amide Proton Transfer

AbstractWe sought to evaluate the utility of radiomics for Amide Proton Transfer weighted (APTw) imaging by assessing its value in differentiating brain metastases from high- and low grade glial brain tumors. We retrospectively identified 48 treatment-naïve patients (10 WHO grade 2, 1 WHO grade 3, 10 WHO grade 4 primary glial brain tumors and 27 metastases) with either primary glial brain tumors or metastases who had undergone APTw MR imaging. After image analysis with radiomics feature extraction and post-processing, machine learning algorithms (multilayer perceptron machine learning algorithm; random forest classifier) with stratified tenfold cross validation were trained on features and were used to differentiate the brain neoplasms. The multilayer perceptron achieved an AUC of 0.836 (receiver operating characteristic curve) in differentiating primary glial brain tumors from metastases. The random forest classifier achieved an AUC of 0.868 in differentiating WHO grade 4 from WHO grade 2/3 primary glial brain tumors. For the differentiation of WHO grade 4 tumors from grade 2/3 tumors and metastases an average AUC of 0.797 was achieved. Our results indicate that the use of radiomics for APTw imaging is feasible and the differentiation of primary glial brain tumors from metastases is achievable with a high degree of accuracy.

scholarly journals Prediction of H3K27M-mutant brainstem glioma by amide proton transfer–weighted imaging and its derived radiomics

2021 ◽  
Author(s):  
Zhizheng Zhuo ◽  
Liying Qu ◽  
Peng Zhang ◽  
Yunyun Duan ◽  
Dan Cheng ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Brainstem Glioma ◽  
Amide Proton ◽  
Amide Proton Transfer

Amide proton transfer imaging for differentiation of tuberculomas from high-grade gliomas: Preliminary experience

2021 ◽  
pp. 197140092110027
Author(s):  
Karthik Kulanthaivelu ◽  
Shumyla Jabeen ◽  
Jitender Saini ◽  
Sanita Raju ◽  
Atchayaram Nalini ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Chemical Exchange ◽  
Spin Echo ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
High Grade ◽  
Saturation Pulse ◽  
Amide Proton Transfer ◽  
High Grade Gliomas ◽  
Amide Protons

Purpose Tuberculomas can occasionally masquerade as high-grade gliomas (HGG). Evidence from magnetisation transfer (MT) imaging suggests that there is lower protein content in the tuberculoma microenvironment. Building on the principles of chemical exchange saturation transfer and MT, amide proton transfer (APT) imaging generates tissue contrast as a function of the mobile amide protons in tissue’s native peptides and intracellular proteins. This study aimed to further the understanding of tuberculomas using APT and to compare it with HGG. Method Twenty-two patients ( n = 8 tuberculoma; n = 14 HGG) were included in the study. APT was a 3D turbo spin-echo Dixon sequence with inbuilt B0 correction. A two-second, 2 μT saturation pulse alternating over transmit channels was applied at ±3.5 ppm around water resonance. The APT-weighted image (APTw) was computed as the MT ratio asymmetry (MTRasym) at 3.5 ppm. Mean MTRasym values in regions of interest (areas = 9 mm2; positioned in component with homogeneous enhancement/least apparent diffusion coefficient) were used for the analysis. Results MTRasym values of tuberculomas ( n = 14; 8 cases) ranged from 1.34% to 3.11% ( M = 2.32 ± 0.50). HGG ( n = 17;14 cases) showed MTRasym ranging from 2.40% to 5.70% ( M = 4.32 ± 0.84). The inter-group difference in MTRasym was statistically significant ( p < 0.001). APTw images in tuberculomas were notable for high MTRasym values in the perilesional oedematous-appearing parenchyma (compared to contralateral white matter; p < 0.001). Conclusion Tuberculomas demonstrate lower MTRasym ratios compared to HGG, reflective of a relative paucity of mobile amide protons in the ambient microenvironment. Elevated MTRasym values in perilesional parenchyma in tuberculomas are a unique observation that may be a clue to the inflammatory milieu.

Dynamic Change of Amide Proton Transfer Imaging in Irradiated Nasopharyngeal Carcinoma and Related Histopathological Mechanism

2021 ◽  
Author(s):  
Qingxu Song ◽  
Pengxiang Chen ◽  
Xin Chen ◽  
Cong Sun ◽  
Jianbo Wang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Proton Transfer ◽  
Dynamic Change ◽  
Amide Proton ◽  
Amide Proton Transfer ◽  
Amide Proton Transfer Imaging
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