Preclinical Development and Validation of ASP5354: A Near-Infrared Fluorescent Agent for Intraoperative Ureter Visualization

2021 ◽  
Author(s):  
Hiroshi Fushiki ◽  
Tomoaki Yoshikawa ◽  
Toshihiro Matsuda ◽  
Takeshi Sato ◽  
Akira Suwa
Keyword(s):  
Near Infrared ◽  
Preclinical Development ◽  
Fluorescent Agent ◽  
Development And Validation

scholarly journals Near-Infrared Fluorescence Imaging and Photodynamic Therapy for Liver Tumors

2021 ◽  
Vol 11 ◽  
Author(s):  
Masaki Kaibori ◽  
Hisashi Kosaka ◽  
Kosuke Matsui ◽  
Morihiko Ishizaki ◽  
Hideyuki Matsushima ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Liver Tumors ◽  
Nir Fluorescence ◽  
Recent Developments ◽  
Fluorescent Agent ◽  
Stable Particles ◽  
And Function ◽  
Cancer Tissues

Surgery with fluorescence equipment has improved to treat the malignant viscera, including hepatobiliary and pancreatic neoplasms. In both open and minimally invasive surgeries, optical imaging using near-infrared (NIR) fluorescence is used to assess anatomy and function in real time. Here, we review a variety of publications related to clinical applications of NIR fluorescence imaging in liver surgery. We have developed a novel nanoparticle (indocyanine green lactosome) that is biocompatible and can be used for imaging cancer tissues and also as a drug delivery system. To date, stable particles are formed in blood and have an ~10–20 h half-life. Particles labeled with a NIR fluorescent agent have been applied to cancer tissues by the enhanced permeability and retention effect in animals. Furthermore, this article reviews recent developments in photodynamic therapy with NIR fluorescence imaging, which may contribute and accelerate the innovative treatments for liver tumors.

Development and validation of a multiwavelength spatial domain near-infrared oximeter to detect cerebral hypoxia-ischemia

2006 ◽  
Vol 11 (6) ◽  
pp. 064022 ◽  
Author(s):  
Lindsey A. Nelson ◽  
John C. McCann ◽  
Andres W. Loepke ◽  
Jun Wu ◽  
Baruch Ben Dor ◽  
...  
Keyword(s):  
Near Infrared ◽  
Spatial Domain ◽  
Cerebral Hypoxia ◽  
Hypoxia Ischemia ◽  
Development And Validation

Development and Validation of an Analytical Method for Identification of Granulated Nicarbazin by near Infrared Reflectance Spectroscopy

1997 ◽  
Vol 5 (1) ◽  
pp. 41-65 ◽  
Author(s):  
K.B. Bradfield ◽  
R.A. Forbes
Keyword(s):  
Near Infrared ◽  
Reflectance Spectroscopy ◽  
Raw Material ◽  
Second Derivative ◽  
Infrared Reflectance ◽  
Near Infrared Reflectance Spectroscopy ◽  
Near Infrared Reflectance ◽  
Distance Method ◽  
Designed Experiments ◽  
Development And Validation

A rapid method was developed for verification of the identity of granulated nicarbazin raw material by near infrared reflectance. A library was developed from 30 second derivative near infrared reflectance spectra obtained from 15 representative batches of nicarbazin. Following identification, new batches were qualified by conformance testing according to the wavelength distance method. The identification/qualification method was validated for selectivity and for ruggedness utilising statistically designed experiments.

scholarly journals A targeted folate receptor-α near-infrared fluorescent agent used for in vitro diagnosis of endometrial cytology

2020 ◽  
Author(s):  
Dongxin Liang ◽  
Xiaoqian Tuo ◽  
Lanbo Zhao ◽  
Kailu Zhang ◽  
Yiran Wang ◽  
...  
Keyword(s):  
Predictive Value ◽  
Near Infrared ◽  
Folate Receptor ◽  
False Positive Rate ◽  
False Negative ◽  
False Negative Rate ◽  
Roc Curve Analysis ◽  
Fluorescent Agent ◽  
In Vitro Diagnosis

AbstractThe aim of this study is to perform the synthesis and evaluation of the new near-infrared targeting fluorescent dye folic acid-ZW800-1 (ZW-FA) and to explore its potential feasibility for in vitro diagnosis of endometrial cancer. Characterisation and Folate receptor-α (FR-α) targeting verification of ZW-FA were performed first and 92 patients were recruited, after liquid-based cytology preparations, during a 15-month period. ZW-FA and Hematoxylin-Eosin (H&E) staining were performed on all cytological slides successively; the histological diagnoses were regarded as the gold standard for ROC curve analysis. The cut-off value of ZW-FA fluorescence intensity is 62.9745; the sensitivity (Se), specificity (Sp), false-negative rate (FNR), false-positive rate (FPR), positive predictive value (PV+) percentage and negative predictive value (PV–) of the ZW-FA method are 84.6%, 85.2%, 15.4%,14.8%, 93.2% and 69.7%, respectively. ZW-FA is potentially efficient for in vitro diagnosis of endometrial lesions based on the FR-α expression level of different endometrial lesions.

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