The protective role of spirulina and β-glucan in African catfish (Clarias gariepinus) against chronic toxicity of chlorpyrifos: hemato-biochemistry, histopathology, and oxidative stress traits

2020 ◽  
Vol 27 (25) ◽  
pp. 31636-31651
Author(s):  
Abd-Allah A. Mokhbatly ◽  
Doaa H. Assar ◽  
Emad W. Ghazy ◽  
Zizy Elbialy ◽  
Sally A. Rizk ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Toxicity ◽  
Clarias Gariepinus ◽  
Protective Role ◽  
African Catfish ◽  
And Oxidative Stress

Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Basiru Olaitan Ajiboye ◽  
Babatunji Emmanuel Oyinloye ◽  
Jennifer Chidera Awurum ◽  
Sunday Amos Onikanni ◽  
Adedotun Adefolalu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Protective Role ◽  
Diabetic Rats ◽  
Gene Expressions ◽  
Ki 67 ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters

Abstract Objectives The current study evaluates the protective role of aqueous extract of Sterculia tragacantha leaf (AESTL) on pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67 and GLP-1R) and oxidative stress parameters in streptozotocin-induced diabetic rats. Methods Diabetes mellitus was induced into the experimental Wistar animals via intraperitoneal (IP) injection of streptozotocin (35 mg/kg body weight) and 5% glucose water was given to the rats for 24 h after induction. The animals were categorized into five groups of 10 rats each as follows normal control, diabetic control, diabetic rats administered AESTL (150 and 300 mg/kg body weight) and diabetic rats administered metformin (200 mg/kg) orally for two weeks. Thereafter, the animals were euthanized, blood sample collected, pancreas harvested and some pancreatic gene expressions (such as insulin, PCNA, PDX-1, KI-67, and GLP-1R)s as well as oxidative stress parameters were analyzed. Results The results revealed that AESTL significantly (p<0.05) reduced fasting blood glucose level, food and water intake, and lipid peroxidation in diabetic rats. Diabetic rats administered different doses of AESTL showed a substantial upsurge in body weight, antioxidant enzyme activities, and pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67, and GLP-1R). Conclusions It can therefore be concluded that AESTL has the ability to protect the pancreas during diabetes mellitus conditions.

scholarly journals Protective Role of UCP2 in Oxidative Stress and Apoptosis during the Silent Phase of an Experimental Model of Epilepsy Induced by Pilocarpine

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Marina Rascio Henriques Dutra ◽  
Regiane dos Santos Feliciano ◽  
Kalil Ribeiro Jacinto ◽  
Telma Luciana Furtado Gouveia ◽  
Eduardo Brigidio ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Role ◽  
Negative Regulator ◽  
Antioxidant Enzyme Activities ◽  
Ucp2 Expression ◽  
Silent Phase ◽  
Ros Formation ◽  
Neuroprotective Actions ◽  
And Oxidative Stress

Neuroprotection is a desirable process in many neurological disorders, yet complex mechanisms involved in this field are not completely understood. The pilocarpine epilepsy model causes potent, seizure-induced excitotoxicity cell death and mitochondria impairment. The present study is aimed at investigating the role of UCP2, a ROS negative regulator, in the neuroprotection after cholinergic insult. Our data demonstrated that UCP2 expression was augmented in the rat hippocampus 3 days after status epilepticus (SE), reaching a peak on the fifth day, then returning to basal levels. Concomitantly, phospho-AKT expression levels were higher in the hippocampus during the early silent phase (5 days after SE). Additionally, it was demonstrated that the blockade of UCP2 by antisense oligonucleotides (ASO) in SE rats successfully diminished both UCP2 mRNA and protein contents. SE ASO rats presented increased mitochondrial proapoptotic factor expression, caspase-3 activity, inflammatory cytokine expression, and ROS formation. Moreover, ASO treatment diminished p-AKT expression and antioxidant enzyme activities after pilocarpine insult. In conclusion, the present results highlight the neuroprotective actions of UCP2, acting in the inhibition of apoptotic factors and oxidative stress, to increase neuron survival after SE onset.

scholarly journals Protective Role of Hypoxia-Inducible Factor-2α against Ischemic Damage and Oxidative Stress in the Kidney

2007 ◽  
Vol 18 (4) ◽  
pp. 1218-1226 ◽  
Author(s):  
Ichiro Kojima ◽  
Tetsuhiro Tanaka ◽  
Reiko Inagi ◽  
Hideki Kato ◽  
Toshiharu Yamashita ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hypoxia Inducible Factor ◽  
Protective Role ◽  
Ischemic Damage ◽  
And Oxidative Stress

Negative impacts of ultraviolet-A radiation on antioxidant and oxidative stress biomarkers of African catfish Clarias gariepinus

2015 ◽  
Vol 14 (7) ◽  
pp. 1337-1345 ◽  
Author(s):  
Ahmed Th. A. Ibrahim
Keyword(s):  
Oxidative Stress ◽  
Clarias Gariepinus ◽  
African Catfish ◽  
Aquatic Species ◽  
Ultraviolet A ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Negative Impacts ◽  
And Oxidative Stress

The present study was carried out to evaluate the ultraviolet-A (UVA) effects on biochemical, oxidative stress and antioxidant changes using aquatic species.

scholarly journals Protective Effect of Vitamin E on Potassium Dichromate-induced Haematoxicity and Oxidative Stress in African Catfish (Clarias gariepinus)

2020 ◽  
pp. 18-31
Author(s):  
O. I. Azeez ◽  
S. F. Braimah
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Potassium Dichromate ◽  
Clarias Gariepinus ◽  
Haemoglobin Concentration ◽  
African Catfish ◽  
Antioxidant Defence System ◽  
Antioxidant Parameters ◽  
Radical Generation ◽  
And Oxidative Stress

Effect of potassium dichromate was studied experimentally in African Catfish (Clarias gariepinus) with and without vitamin E in induced haematoxicity and oxidative stress. Blood samples were collected for haematology and plasma biochemical parameters while gills, liver and kidney samples were collected for evaluation of markers of oxidative stress. Exposure to potassium dichromate led to a significant decrease in PCV, RBC, haemoglobin concentration, MCV, MCH and total WBC when compared with the unexposed     control and those fed with vitamin E-supplemented feed. Nephrotoxicity was also observed as evidenced by increases in plasma creatinine levels. Exposure to potassium dichromate also led to increased oxidative stress as the concentrations of antioxidant endogenous enzymes - GPx, GST and GSH were depleted while potentiating lipid peroxidation and hydroxyl radical generation. The changes in the haematological, biochemical and antioxidant parameters were restored in the fish fed with vitamin E-supplemented feed. The study showed exposure to potassium dichromate to be toxic to African catfish, causing anaemia and kidney damage with free radical generation and depletion of GSH and other antioxidant defence system but the toxic effect can be minimised along with weight gain in fish supplemented by vitamin – E in aquaculture.

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