Paracetamol-induced changes of haematobiochemical and oxidative stress parameters in rat blood: Protective role of vitamin C and β-glucan

Abstract Objectives The current study evaluates the protective role of aqueous extract of Sterculia tragacantha leaf (AESTL) on pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67 and GLP-1R) and oxidative stress parameters in streptozotocin-induced diabetic rats. Methods Diabetes mellitus was induced into the experimental Wistar animals via intraperitoneal (IP) injection of streptozotocin (35 mg/kg body weight) and 5% glucose water was given to the rats for 24 h after induction. The animals were categorized into five groups of 10 rats each as follows normal control, diabetic control, diabetic rats administered AESTL (150 and 300 mg/kg body weight) and diabetic rats administered metformin (200 mg/kg) orally for two weeks. Thereafter, the animals were euthanized, blood sample collected, pancreas harvested and some pancreatic gene expressions (such as insulin, PCNA, PDX-1, KI-67, and GLP-1R)s as well as oxidative stress parameters were analyzed. Results The results revealed that AESTL significantly (p<0.05) reduced fasting blood glucose level, food and water intake, and lipid peroxidation in diabetic rats. Diabetic rats administered different doses of AESTL showed a substantial upsurge in body weight, antioxidant enzyme activities, and pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67, and GLP-1R). Conclusions It can therefore be concluded that AESTL has the ability to protect the pancreas during diabetes mellitus conditions.

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Role of vitamin C against bifenthrin induced oxidative damage in lungs of Wistar rats

Journal of Applied and Natural Science ◽

10.31018/jans.v8i1.798 ◽

2016 ◽

Vol 8 (1) ◽

pp. 346-349

Author(s):

Muneer Ahmad Dar ◽

Rajinder Raina ◽

Arshad Hussain Mir ◽

Pawan Kumar Verma ◽

Mahrukh Ahmad

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Vitamin C ◽

Protective Role ◽

Group Iv ◽

Control Value ◽

Oxidative Stress Parameters ◽

Group I ◽

Stress Parameters

The aim of present study was to unravel the protective role of vitamin C on oxidative stress parameters in lung homogenates of bifenthrin intoxicated rats. Rats were divided into four groups. Group I served as control while group II animals were treated with bifenthrin @ 5.8mg/Kg/day. In group III, vitamin C was orally administered @ 60mg/Kg/day where as group IV received both vitamin C and bifenthrin @ 60mg/Kg/day and 5.8mg/Kg/day respectively. After 30th day of treatment, lung samples were taken and analysed for oxidative stress parameters. Significant (P<0.05) increase in lipid peroxidation was observed from control value of 4.80Â±0.39 to 7.90Â±0.50 in bifenthrin treated animals. Mean control values of SOD, GSH-Px and CAT were 0.55Â±0.05, 0.98Â±0.03 and 138.70Â±6.01 which were significantly (P<0.05) decreased to values of 0.27Â±0.0, 0.53Â±0.05 and 91.10Â±9.70 respectively in bifenthrin treated animals. The value of GST increased significantly (p<0.05) to 1.05Â±0.06 in bifenthrin administered animals from control value of 0.70Â±0.08. Pre-treatment with vitamin C in ameliorative group IV significantly restored the normal values of lipid peroxidation, SOD, GST and CAT but could not reverse the decreased values of GSH-Px. The present research is first of its type where in free radical generation due to bifenthrin â€“a commonly used insecticide was evaluated in lung homogenates when given orally which might be due to residues present in the lung. Besides it will be helpful in better understanding of toxicological profile of pyrethoids, the most commonly used insecticides.

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Protective role of Nano-Se as an antioxidant on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats

Toxicology Letters ◽

10.1016/j.toxlet.2011.05.840 ◽

2011 ◽

Vol 205 ◽

pp. S246

Author(s):

M.A. Rezvanfar ◽

A. Ahmadi ◽

M. Baeeri ◽

M. Abdollahi

Keyword(s):

Oxidative Stress ◽

Protective Role ◽

Testicular Damage ◽

Sperm Characteristics ◽

Induced Changes ◽

And Oxidative Stress

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Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats

Reproductive Toxicology ◽

10.1016/j.reprotox.2005.05.003 ◽

2006 ◽

Vol 21 (1) ◽

pp. 42-47 ◽

Cited By ~ 138

Author(s):

Ahmet Ateşşahin ◽

İzzet Karahan ◽

Gaffari Türk ◽

Seyfettin Gür ◽

Seval Yılmaz ◽

...

Keyword(s):

Oxidative Stress ◽

Protective Role ◽

Testicular Damage ◽

Sperm Characteristics ◽

Induced Changes ◽

And Oxidative Stress

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Anandamide reverses depressive-like behavior, neurochemical abnormalities and oxidative-stress parameters in streptozotocin-diabetic rats: Role of CB1 receptors

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2016.08.007 ◽

2016 ◽

Vol 26 (10) ◽

pp. 1590-1600 ◽

Cited By ~ 18

Author(s):

Helen de Morais ◽

Camila P. de Souza ◽

Luisa M. da Silva ◽

Daniele M. Ferreira ◽

Cristiane Hatsuko Baggio ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetic Rats ◽

Cb1 Receptors ◽

Oxidative Stress Parameters ◽

Streptozotocin Diabetic Rats ◽

And Oxidative Stress ◽

Stress Parameters

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Evaluation of protective role of selenium on mercury toxicity by superoxide dismutase, catalase and malondialdehyde parameters in Oreochromis niloticus (Linnaeus, 1758)

Ege Journal of Fisheries and Aquatic Sciences ◽

10.12714/egejfas.2019.36.3.05 ◽

2019 ◽

Vol 36 (3) ◽

pp. 245-253 ◽

Cited By ~ 1

Author(s):

Özgür Fırat ◽

Özlem Kaya

Keyword(s):

Oxidative Stress ◽

Superoxide Dismutase ◽

Protective Effect ◽

Oreochromis Niloticus ◽

Exposure Period ◽

Protective Role ◽

Mercury Toxicity ◽

Oxidative Stress Parameters ◽

Stress Parameters

In this research, to determine toxicity of mercury (Hg) and whether selenium (Se) has any role in protection of this toxicity, it was investigated the alterations in oxidative stress parameters in tissues of Oreochromis niloticus. For this purpose, fish were exposed to 0.01 and 0.05 ppm Hg and 0.01 ppm Hg+0.01 ppm Se and 0.05 ppm Hg+0.05 ppm Se for 4 and 21 days and activities of superoxide dismutase (SOD) and catalase (CAT) and levels of malondialdehyde (MDA) in gill and liver were determined. It was observed significant changes in all analyzed parameters due to tissue, medium concentration and exposure period in the exposure of mercury alone and Hg+Se mixtures. In Hg alone, and in combination with Se especially in their higher medium concentrations, activities of SOD and CAT in the gill and liver significantly increased at 4 days (P˂0.05), while they significantly decreased at 21 days (P˂0.05). In the exposure of Hg and Hg+Se and in the both tissues, it not determined significant alteration in the MDA levels at 4 days (P˃0.05), while they elevated in their higher concentrations at 21 days (P˂0.05). In conclusion, it was determined the increases or decreases in activities of SOD and CAT and levels of MDA in O. niloticus were higher in the Hg alone than Hg+Se mixtures and selenium has a protective effect on oxidative toxicity of mercury.

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