Investigation of levels of perfluoroalkyl substances in freshwater fishes collected in a contaminated area of Veneto Region, Italy

2021 ◽  
Author(s):  
Federica Gallocchio ◽  
Marzia Mancin ◽  
Simone Belluco ◽  
Alessandra Moressa ◽  
Roberto Angeletti ◽  
...  
Keyword(s):  
Freshwater Fishes ◽  
Perfluoroalkyl Substances ◽  
Veneto Region ◽  
Contaminated Area

scholarly journals Perfluoroalkyl substances and lipid profile in exposed pregnant women in the Veneto Region, Italy

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
T Dalla Zuanna ◽  
G Barbieri ◽  
G Pitter ◽  
M Zare Jeddi ◽  
F Daprà ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Plasma Concentrations ◽  
Density Lipoprotein ◽  
Additive Models ◽  
Lipoprotein Cholesterol ◽  
Perfluoroalkyl Substances ◽  
Surveillance Program ◽  
Veneto Region ◽  
Exposed Population

Abstract Background Perfluoroalkyl substances (PFASs) are persistent and widespread environmental pollutants. Residents of a large area of the Veneto Region (North-Eastern Italy) were exposed to high concentrations of PFASs through drinking water from the late-1970s to 2013. PFASs have been consistently associated with raised serum lipids, but only few studies have been conducted among pregnant women, and none has stratified analyses by trimesters of gestation. Our main objective was to evaluate the association between perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) levels and lipid profiles in high-exposed pregnant women. Methods A cross-sectional analysis was conducted in 319 pregnant women (age 14-48 years) recruited in the Regional health surveillance program. Serum PFASs were measured by HPLC-MS/MS. Non-fasting serum total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were measured by enzymatic assays in automated analysers, and low-density lipoprotein cholesterol (LDL-C) was calculated. The associations between ln-transformed PFASs (and categorized into quartiles) and lipids were assessed using generalized additive models. Analyses were adjusted for potential confounders and stratified according to pregnancy trimester. Results In the first trimester, plasma concentrations of both PFOA and PFOS were positively associated with TC. However in the third trimester PFOA levels were instead inversely significantly associated with TC and LDL-C levels. Overall, both PFOA and PFOS were positively associated with HDL-C, and PFOA negatively with LDL-C. Conclusions In a small highly exposed population of pregnant women, the associations between PFASs concentrations and lipid profile were modified by trimester of gestation. Patterns late in pregnancy were different to the positive associations with LDL-C generally found. Differential transfer and bioaccumulation of lipids and PFAS in the placenta across gestation might explain our findings. Key messages This study provides evidence of different patterns of PFAS associations with lipids in pregnant women across the trimesters of gestation. The different patterns of association from general population studies sheds light on the role of fetal nutrition during pregnancy affecting both lipids and PFAS in serum.

scholarly journals Perfluoroalkyl substances and blood pressure in exposed young population in the Veneto Region, Italy

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
C Canova ◽  
M Jare Zeddi ◽  
G Barbieri ◽  
M Gion ◽  
F Daprà ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Sulfonic Acid ◽  
Antihypertensive Drugs ◽  
Adult Population ◽  
Additive Models ◽  
Perfluoroalkyl Substances ◽  
Surveillance Program ◽  
Veneto Region ◽  
Large Area

Abstract Background Residents in a large area of the Veneto Region (North-Eastern Italy) were exposed to perfluoroalkyl substances (PFASs) via drinking water. Studies on the association between PFASs and blood pressure (BP) levels are limited and results are inconsistent. Using cross-sectional data from the Regional health surveillance program, we aimed to quantify the associations between PFAS serum concentrations and blood pressure and hypertension prevalence. Methods The study included 16,224 individuals aged 20-39 years. Pregnant women (n = 327), participants with self-reported diagnosis or under treatment (n = 296) or with missing information on the selected covariates (n = 114) were excluded, leaving 15,487 subjects. Hypertension (HYP) was defined as any self-reported diagnosis, use of antihypertensive drugs, or raised systolic/diastolic blood pressure (SBP)≥140, DBP ≥90 mmHg). Serum PFASs were measured by HPLC-MS. Generalized additive models were used to investigate the relation between each PFAS (perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA)) ln transformed and by decile, and SBP, DBP, HYP, adjusted for potential confounders. Results Both SBP and DBP increased significantly with an increase in the ln-transformed serum PFASs concentration in a monotonic way. The predicted increase in SBP and DBP were 1.62 (95% CI = 0.69, 2.55), 1.64 mmHg (95% CI = 0.96, 2.31) from lowest to highest decile of PFOA. The associations were stronger for SBP in men and DBP in women. One unit increase in each ln-PFAS was positively associated with an increased odds of HYP in men: PFOA OR = 1.07 (1.01-1.14), PFOS OR = 1.18 (1.05-1.32), PFHxS OR = 1.11 (1.03-1.19), PFNA OR = 1.19 (1.01-1.41). Conclusions Our findings suggest that exposure to PFAS is associated with increased blood pressure and thus may contribute as a risk factor for the development of cardiovascular diseases. Key messages Serum PFASs were associated with raised systolic blood pressure in men and diastolic blood pressure in women in a large highly exposed young adult population. Serum PFASs were associated with raised prevalence of hypertension in men.

scholarly journals The association between perfluoroalkyl substances and lipid profile in exposed pregnant women in the Veneto region, Italy

2021 ◽  
Vol 209 ◽  
pp. 111805
Author(s):  
Teresa Dalla Zuanna ◽  
David A. Savitz ◽  
Giulia Barbieri ◽  
Gisella Pitter ◽  
Maryam Zare Jeddi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Perfluoroalkyl Substances ◽  
Veneto Region

scholarly journals Drinking water contamination from perfluoroalkyl substances (PFAS): an ecological mortality study in the Veneto Region, Italy

2017 ◽  
Vol 28 (1) ◽  
pp. 180-185 ◽  
Author(s):  
Marina Mastrantonio ◽  
Edoardo Bai ◽  
Raffaella Uccelli ◽  
Vincenzo Cordiano ◽  
Augusto Screpanti ◽  
...  
Keyword(s):  
Drinking Water ◽  
Water Contamination ◽  
Perfluoroalkyl Substances ◽  
Veneto Region ◽  
Drinking Water Contamination ◽  
Mortality Study

Perfluoroalkyl substances and thyroid stimulating hormone levels in a highly exposed population in the Veneto Region

2021 ◽  
pp. 111794
Author(s):  
Elisa Gallo ◽  
Claudio Barbiellini Amidei ◽  
Giulia Barbieri ◽  
S.C. Fabricio Aline ◽  
Massimo Gion ◽  
...  
Keyword(s):  
Thyroid Stimulating Hormone ◽  
Perfluoroalkyl Substances ◽  
Veneto Region ◽  
Hormone Levels ◽  
Exposed Population ◽  
Stimulating Hormone

scholarly journals Associations of Perfluoroalkyl Substances with Prevalence of Metabolic Syndrome in Highly Exposed Young Adult Community Residents—A Cross-Sectional Study in Veneto Region, Italy

2021 ◽  
Vol 18 (3) ◽  
pp. 1194
Author(s):  
Maryam Zare Jeddi ◽  
Teresa Dalla Zuanna ◽  
Giulia Barbieri ◽  
Aline S. C. Fabricio ◽  
Francesca Daprà ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Young Adult ◽  
Sulfonic Acid ◽  
Serum Levels ◽  
Additive Models ◽  
Elevated Blood Pressure ◽  
Perfluoroalkyl Substances ◽  
Veneto Region ◽  
Elevated Blood

Background: Studies on the association between perfluoroalkyl substances (PFAS) and metabolic syndrome (MetS) are limited, and results are inconsistent. We aimed to examine the associations between PFAS serum levels and the prevalence of MetS among highly exposed young adults (ages 20–39) residents of a large area of the Veneto Region (North-Eastern Italy) primarily stemming from PFAS water contamination before September 2013. A total of 15,876 eligible young adult residents living in the investigated municipalities were enrolled in the study from January 2017 to July 2019. Methods: MetS was defined by using a modified harmonized definition requiring the presence of 3 of the following: obesity (body mass index ≥30), elevated triglyceride (TG), reduced high-density lipoprotein cholesterol, elevated blood pressure, and hemoglobin A1c ≥ 6.1% or self-reported diabetes mellitus or drug treatment for hyperglycemia. Multivariable generalized additive models were performed to identify the associations between four serum PFAS, including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), and risk of MetS controlling for potential confounders. Results: A total of 1282 participants (8.1%) met the criteria of MetS with a higher prevalence among men. PFOA, PFHxS, and PFNA were not associated with the risk of MetS, whereas PFOS showed a consistent protective effect against the risk of MetS (OR 0.76, (95% CI: 0.69, 0.85) per ln-PFOS). However, we found statistically significant positive associations between PFAS serum levels and individual components of MetS, mainly elevated blood pressure and elevated TG. Conclusion: Our results did not support a consistent association between PFAS and MetS and conflicting findings were observed for individual components of MetS.

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