scholarly journals The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice

AGE ◽  
2013 ◽  
Vol 36 (2) ◽  
pp. 689-703 ◽  
Author(s):  
Wei-Sheng Lin ◽  
Jun-Yi Chen ◽  
Jo-Chiao Wang ◽  
Liang-Yu Chen ◽  
Che-Hao Lin ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Aging Effects ◽  
Samp8 Mice

scholarly journals Ayurvedic Amalaki Rasayana promotes improved stress tolerance and thus has anti-aging effects in Drosophila melanogaster

2016 ◽  
Author(s):  
Vibha Dwivedi ◽  
Subhash C. Lakhotia
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Drosophila Melanogaster ◽  
Stress Tolerance ◽  
Healthy Aging ◽  
Phyllanthus Emblica ◽  
Wild Type ◽  
Aging Effects ◽  
Sod Activity ◽  
Normal Food

AbstractEthnopharmacological relevanceAmalaki Rasayana (AR) is a common Ayurvedic herbal formulation of Phyllanthus emblica fruits and other ingredients and is used for general good health and healthy aging. We earlier reported it to improve life history traits and to suppress neurodegeneration as well as induced apoptosis in Drosophila.Aim of the studyTo examine effects of dietary AR supplement on cell stress responses in Drosophila melanogaster.Materials and methodsLarvae/flies, reared on normal food or on that supplemented with 0.5% (w/v) AR, were exposed to crowding, thermal or oxidative stress and examined for survival, stress tolerance and levels of lipid peroxides, SOD and HSPs.ResultsWild type larvae/flies reared on AR supplemented food survived the various cell stresses much better than those reared on normal food. AR-fed mutant park13 or DJ-1βDelta93 (Parkinson’s disease model) larvae, however, showed only partial or no protection, respectively, against paraquat-induced oxidative stress, indicating essentiality of DJ-1β for AR mediated oxidative stress tolerance. AR feeding reduced the accumulation of reactive oxygen species (ROS) and lipid peroxidation even in aged (35 day old) wild type flies while enhancing superoxide dismutase (SOD) activity. We show for the first time that while Hsp70 or Hsp83 expression under normal or stress conditions was not differentially affected by AR feeding, Hsp27 levels were elevated in AR fed wild type control as well as heat shocked larvae. Therefore, besides the known anti-oxidant activity of Phyllanthus emblica fruits, dietary AR also enhances cellular levels of Hsp27.ConclusionIn the context of the reported “anti-aging” and “healthy-aging” effects of AR, the present in vivo study on a model organisms shows that AR feeding significantly improves tolerance to a variety of cell stresses through reduced ROS and lipid peroxidation and enhanced SOD activity and Hsp27. Such improved cellular defences following dietary AR provide better homeostasis and thereby improve the life-span and quality of organism’s life.

Bioactive peptides derived from crimson snapper and in vivo anti-aging effects on fat diet-induced high fat Drosophila melanogaster

2020 ◽  
Vol 11 (1) ◽  
pp. 524-533 ◽  
Author(s):  
Shengyang Chen ◽  
Qian Yang ◽  
Xuan Chen ◽  
Yongqi Tian ◽  
Zhiyu Liu ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Drosophila Melanogaster ◽  
Bioactive Peptides ◽  
Aging Effects ◽  
High Fat

Crimson snapper scale peptides (CSSPs) prepared from crimson snapper scales exhibited significant antioxidant activity in vitro and anti-aging effects in vivo on fat diet-induced high fat Drosophila melanogaster.

scholarly journals Anti-aging effects of Lasia spinosa L. stem extract on Drosophila melanogaster

2021 ◽  
Author(s):  
Tran Thanh MEN ◽  
Do Tan KHANG ◽  
Nguyen Trong TUAN ◽  
Dai Thi Xuan TRANG
Keyword(s):  
Drosophila Melanogaster ◽  
Aging Effects ◽  
Stem Extract

scholarly journals Effects of Moxa Smoke on Monoamine Neurotransmitters in SAMP8 Mice

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Huanfang Xu ◽  
Baixiao Zhao ◽  
Yingxue Cui ◽  
Min Yee Lim ◽  
Ping Liu ◽  
...  
Keyword(s):  
Factorial Design ◽  
Normal Control ◽  
Model Group ◽  
Aging Effects ◽  
Monoamine Neurotransmitter ◽  
Monoamine Neurotransmitters ◽  
Group 5 ◽  
Samp8 Mice ◽  
Exposure Length

Objectives. To investigate the anti-aging effects of moxa smoke on SAMP8 mice.Methods. Using2×3factorial design, exposure length (15 or 30 minutes daily), and concentration (low, 5–15 mg/m3; middle, 25–35 mg/m3; high, 85–95 mg/m3), 70 SAMP8 mice were randomly assigned,n=10/group, to a model group or one of six moxa smoke groups: L1, L2, M1, M2, H1, or H2. Ten SAMR1 mice were used as normal control. Mice in moxa smoke groups were exposed to moxa smoke at respective concentrations and exposure lengths; the model and normal control mice were not exposed. Cerebral 5-HT, DA, and NE levels were determined using ELISA.Results. Compared to normal control, the model group showed a significant decrease in 5-HT, DA, and NE. Compared to model group, 5-HT and NE were significantly higher in groups L2, M1, and M2and DA was significantly so in L2and M1. 5-HT, DA, and NE levels were the highest in group M1among moxa smoke groups. A marked exposure length × concentration interaction was observed for 5-HT, DA, and NE.Conclusion. Moxa smoke increases monoamine neurotransmitter levels, which varies according to concentration and exposure length. Our finding suggests that the middle concentration of moxa smoke for 15 minutes seems the most beneficial.

Apoptosis inhibition mitigates aging effects in Drosophila melanogaster

Genetica ◽  
2020 ◽  
Vol 148 (2) ◽  
pp. 69-76
Author(s):  
Hiroaki Kidera ◽  
Toshimitsu Hatabu ◽  
Kazuo H. Takahashi
Keyword(s):  
Drosophila Melanogaster ◽  
Aging Effects ◽  
Apoptosis Inhibition

Author response for "Location and arrangement of campaniform sensilla in Drosophila melanogaster"

2020 ◽  
Author(s):  
Gesa F. Dinges ◽  
Alexander S. Chockley ◽  
Till Bockemühl ◽  
Kei Ito ◽  
Alexander Blanke ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Author Response ◽  
Campaniform Sensilla

Live Confocal Analysis of Fertilization and Early Development

2001 ◽  
Vol 7 (S2) ◽  
pp. 1012-1013
Author(s):  
Uyen Tram ◽  
William Sullivan
Keyword(s):  
Drosophila Melanogaster ◽  
Embryonic Development ◽  
Real Time ◽  
Early Development ◽  
Fluorescent Probes ◽  
Primary Defect ◽  
Fluorescent Analysis ◽  
Dynamic Event ◽  
Enormous Amount ◽  
Fluorescent Studies

Embryonic development is a dynamic event and is best studied in live animals in real time. Much of our knowledge of the early events of embryogenesis, however, comes from immunofluourescent analysis of fixed embryos. While these studies provide an enormous amount of information about the organization of different structures during development, they can give only a static glimpse of a very dynamic event. More recently real-time fluorescent studies of living embryos have become much more routine and have given new insights to how different structures and organelles (chromosomes, centrosomes, cytoskeleton, etc.) are coordinately regulated. This is in large part due to the development of commercially available fluorescent probes, GFP technology, and newly developed sensitive fluorescent microscopes. For example, live confocal fluorescent analysis proved essential in determining the primary defect in mutations that disrupt early nuclear divisions in Drosophila melanogaster. For organisms in which GPF transgenics is not available, fluorescent probes that label DNA, microtubules, and actin are available for microinjection.

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