Protective effects of an acidic polysaccharide isolated from fruiting bodies of Ganoderma lucidum against murine hepatic injury induced by Propionibacterium acnes and lipopolysaccharide

Hepatic injury is one of the most common complications associated with cisplatin (CIS) use. Recently, liver protection lines are being discovered to stop the hepatic cell death due to inflammatory and apoptotic perturbations. l-arginine has protective effects in several models of liver injury. This study was designed to investigate the possible protective effect of l-arginine against CIS-induced acute hepatic injury in rats. Rats were divided into 4 groups: control, l-arginine, CIS, l-arginine + CIS. Liver function, oxidative stress, inflammatory cytokines, and apoptosis markers were assessed. l-arginine pretreatment protected the liver against CIS-induced toxicity as indicated by significantly alleviating the changes in liver function along with restoration of the antioxidant status. This finding was confirmed with the markedly improved pathological changes. l-arginine showed anti-inflammatory effect through the reduction of liver expression of iNOS, TNF-α, and NF-κβ, which were ameliorated to significant levels. Furthermore, l-arginine administration downregulated the liver expression of the apoptotic marker, caspase-3. The results recommend l-arginine as a hepatoprotective agent against CIS toxicity. Mostly, this hepatoprotective effect of l-arginine involved anti-inflammatory and anti-apoptotic activities.

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Lanostane-type Triterpenoids from Ganoderma lucidum and G. multipileum Fruiting Bodies

Natural Product Communications ◽

10.1177/1934578x1801301107 ◽

2018 ◽

Vol 13 (11) ◽

pp. 1934578X1801301

Author(s):

Pham Thanh Binh ◽

Nguyen Phuong Thao ◽

Nguyen Thi Luyen ◽

Duong Thu Trang ◽

Phung Thi Xuan Binh ◽

...

Keyword(s):

Ganoderma Lucidum ◽

Spectroscopic Data ◽

Fruiting Bodies

Sixteen lanostane-type triterpeneoids were isolated from the fruiting bodies of wild Ganoderma lucidum and G. multipileum. The new structures 3 S,24 S,25,26-tetrahydroxy-5α-lanost-8-en-11-one (1) and ganodermanondiol 24,25-acetonide (10) were elucidated by means of spectroscopic data and Mosher's experiments. Lanosta-7,9(11)-dien-3β-ol (9) strongly inhibited α-glucosidase with the IC50 values of 198.8 μM in compared with acarbose (IC50 712.4 μM).

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Ganoderma lucidum (Curt.: Fr.) Karst. – health-promoting properties. A review

Herba Polonica ◽

10.1515/hepo-2015-0026 ◽

2015 ◽

Vol 61 (3) ◽

pp. 105-118 ◽

Cited By ~ 14

Author(s):

Marek Siwulski ◽

Krzysztof Sobieralski ◽

Iwona Golak-Siwulska ◽

Sławomir Sokół ◽

Agnieszka Sękara

Keyword(s):

Ganoderma Lucidum ◽

Heart Diseases ◽

Physiological Effects ◽

Fruiting Bodies ◽

Positive Effects ◽

Anti Cancer ◽

Prevention And Treatment ◽

Life Threatening ◽

Health Promoting ◽

Active Substances

SummaryThis paper presents the characteristics of the speciesGanoderma lucidumin terms of health-promoting properties. This species is rare in Poland, and is subject to strict protection. Reishi is classified as a medicinal mushroom which fruiting bodies are characterized by a content of active substances with diverse positive effects on human health.G. lucidumis particularly rich source of bioactive compounds, which are obtained from fruiting bodies, mycelium and spores of this species. The therapeutic effect ofG. lucidumextracts has been demonstrated in many scientific studies. The most important pharmacological and physiological effects include: immunomodulatory, anti-cancer, anti-inflammatory, antiviral, anti-atherosclerosis, antidiabetic and anti-aging. Reishi has also a beneficial effect on liver cells and the cardiovascular system and protects in case of stomach ulcers. Due to its propertiesG. lucidumcan be used in the prevention and treatment of life-threatening diseases, such as cancer, stroke and heart diseases.

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