Preparation and in vitro cytotoxicity study of poly (aspartic acid) stabilized magnetic nanoparticles

Aim: To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging. Materials & methods: Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with their in vitro cytotoxicity assessed, followed by imaging assessments. Results: The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal. Conclusion: We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.

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Functionalization of γ-Fe2O3@SiO2 nanoparticles using the antiviral drug zidovudine: synthesis, characterization, in vitro cytotoxicity and DNA interaction studies

RSC Advances ◽

10.1039/c6ra16564h ◽

2016 ◽

Vol 6 (77) ◽

pp. 73605-73616 ◽

Cited By ~ 12

Author(s):

Nahid Shahabadi ◽

Monireh Falsafi ◽

Foroozan Feizi ◽

Reza Khodarahmi

Keyword(s):

Magnetic Nanoparticles ◽

Drug Targeting ◽

Antiviral Drug ◽

Sio2 Nanoparticles ◽

Dna Interaction ◽

In Vitro Cytotoxicity ◽

Biological Applications ◽

Interaction Studies

The aim of this study was to design and prepare γ-Fe2O3@SiO2-zidovudine magnetic nanoparticles (MNPs) for magnetic guided drug targeting and biological applications.

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Facile Synthesis and Characterization of L-Aspartic Acid Coated Iron Oxide Magnetic Nanoparticles (IONPs) For Biomedical Applications

Drug Research ◽

10.1055/s-0043-120197 ◽

2017 ◽

Vol 68 (05) ◽

pp. 280-285 ◽

Cited By ~ 25

Author(s):

Marziyeh Salehiabar ◽

Hamed Nosrati ◽

Soodabeh Davaran ◽

Hossein Danafar ◽

Hamidreza Manjili

Keyword(s):

Electron Microscopy ◽

Iron Oxide ◽

Magnetic Nanoparticles ◽

Aspartic Acid ◽

Precipitation Method ◽

Scanning Calorimetry ◽

One Pot ◽

Iron Oxide Magnetic Nanoparticles

AbstractNatural L-aspartic acid coated iron oxide magnetic nanoparticles (Asp@IONPs) were prepared by a one pot, in-situ and green co–precipitation method in an aqueous medium. Functionalized iron oxide magnetic nanoparticles (IONPs) were characterized by Vibrating Sample Magnetometer (VSM), X-ray diffraction (XRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM) techniques. Cellular toxicity of IONPs was also investigated on HEK-293 cell lines. The results showed that the zeta potential of Asp@IONPs was about −21.1 mV and the average size was 17.80±3.09 nm. Cell toxicity results show that as prepared IONPs are biocompatible. Asp@IONPs show the possibility of using these nanoparticles in the development of in vitro and in vivo biomedical fields due to do not possess a toxic effect, good ζ-potential and related small and narrow size distribution.

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The effect of grafting method on the colloidal stability and in vitro cytotoxicity of carboxymethyl dextran coated magnetic nanoparticles

Journal of Materials Chemistry ◽

10.1039/c0jm01504k ◽

2010 ◽

Vol 20 (39) ◽

pp. 8539 ◽

Cited By ~ 41

Author(s):

Mar Creixell ◽

Adriana P. Herrera ◽

Magda Latorre-Esteves ◽

Vanessa Ayala ◽

Madeline Torres-Lugo ◽

...

Keyword(s):

Magnetic Nanoparticles ◽

Colloidal Stability ◽

In Vitro Cytotoxicity ◽

Carboxymethyl Dextran

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Characterization, in vitro cytotoxicity assessment, and in vivo visualization of multimodal, RITC-labeled, silica-coated magnetic nanoparticles for labeling human cord blood–derived mesenchymal stem cells

Nanomedicine Nanotechnology Biology and Medicine ◽

10.1016/j.nano.2009.07.005 ◽

2010 ◽

Vol 6 (2) ◽

pp. 263-276 ◽

Cited By ~ 58

Author(s):

Ki-Soo Park ◽

Jinsung Tae ◽

Bongkum Choi ◽

Young-Seok Kim ◽

Cheol Moon ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Magnetic Nanoparticles ◽

Cord Blood ◽

In Vitro Cytotoxicity ◽

Human Cord Blood ◽

Cytotoxicity Assessment

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Chemotherapeutic potential of L-carnosine from stimuli-responsive magnetic nanoparticles against breast cancer model

Nanomedicine ◽

10.2217/nnm-2019-0428 ◽

2020 ◽

Vol 15 (9) ◽

pp. 891-911

Author(s):

Ragwa M Farid ◽

Passent M E Gaafar ◽

Heba A Hazzah ◽

Maged W Helmy ◽

Ossama Y Abdallah

Keyword(s):

Magnetic Nanoparticles ◽

Targeted Delivery ◽

Physicochemical Characterization ◽

Tumor Model ◽

Entrapment Efficiency ◽

In Vitro Cytotoxicity ◽

Scanning Calorimetry ◽

Chemotherapeutic Activity

Aim: L-carnosine-coated magnetic nanoparticles (CCMNPs) were developed to enhance chemotherapeutic activity of carnosine-dipeptide. Materials & methods: Surface grafting of MNPs with carnosine was contended by differential scanning calorimetry, infrared spectroscopy and x-ray diffraction. Physicochemical characterization and in vitro cytotoxicity on MCF-7 cell line was carried out. In vivo chemotherapeutic activity and toxicity was assessed by an Ehrlich Ascites tumor model. Results: CCMNPs possessed monodispersed size (120 nm), ζ (-27.3 mV), magnetization (51.52 emu/g) and entrapment efficiency (88.3%) with sustained release rate. CCMNPs showed 2.3-folds lower IC50 values compared with carnosine solution after 48 h. Targeted CCMNPs were specifically accumulated in tumor showing significant reduction in tumor size with no systemic toxicity. Significant reduction in VEGF and cyclin D1 levels were observed. Conclusion: The developed system endowed with responsiveness to an external stimulus can represent a promising magnetically targeted delivery system for carnosine site specific delivery.

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