Antitumor Effects of Ethanol Extract from Ventilago leiocarpa Benth on Sarcoma 180 Tumor-Bearing Mice and Possible Immune Mechanism

2021 ◽  
Author(s):  
Dao-Hai Cheng ◽  
Ying Liu ◽  
Li Wang
Keyword(s):  
Ethanol Extract ◽  
Sarcoma 180 ◽  
Immune Mechanism ◽  
Antitumor Effects ◽  
Tumor Bearing

scholarly journals Ganoderma formosanum Exopolysaccharides Inhibit Tumor Growth via Immunomodulation

2021 ◽  
Vol 22 (20) ◽  
pp. 11251
Author(s):  
Hsing-Chun Kuo ◽  
Yen-Wenn Liu ◽  
Chi-Chin Lum ◽  
Kai-Di Hsu ◽  
Shin-Ping Lin ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Carcinoma Cell ◽  
Culture Conditions ◽  
Lymphocyte Subpopulation ◽  
Mice Model ◽  
Cytokine Mrna ◽  
Antitumor Effects ◽  
Tumor Bearing ◽  
Therapeutic Model ◽  
Ganoderma Formosanum

Ganoderma formosanum (GF) is a medicinal mushroom endemic to Taiwan. Previous research established the optimal culture conditions to produce exopolysaccharide rich in β-glucan (GF-EPS) from submerged fermentation of GF. The present study investigated the antitumor effects of GF-EPS in a Lewis lung carcinoma cell (LLC1) tumor-bearing mice model. In the preventive model, GF-EPS was orally administered to mice before LLC1 injection. In the therapeutic model, GF-EPS oral administration was initiated five days after tumor cell injection. The tumor size and body weight of the mice were recorded. After sacrifice, the lymphocyte subpopulation was analyzed using flow cytometry. Spleen tissues were used to analyze cytokine mRNA expression. The results showed that GF-EPS (80 mg/kg) effectively suppressed LLC1 tumor growth in both the preventive and therapeutic models. GF-EPS administration increased the proportion of natural killer cells in the spleen and activated gene expression of several cytokines. Our results provide evidence that GF-EPS promotes tumor inhibition through immunomodulation in tumor-bearing mice.

Antitumor Ability of Berberine Accompanied by Modulation of Gut Microbiome in Sarcoma-180 Tumor-bearing Mice

2018 ◽  
Vol 14 (4) ◽  
pp. 460-470 ◽  
Author(s):  
Yanhong Yang ◽  
Zili Lei ◽  
Li Huang ◽  
Fei Yang ◽  
Na Zhang ◽  
...  
Keyword(s):  
Gut Microbiome ◽  
Sarcoma 180 ◽  
Tumor Bearing

Maitake D-Fraction enhances antitumor effects and reduces immunosuppression by mitomycin-C in tumor-bearing mice

Nutrition ◽  
2005 ◽  
Vol 21 (5) ◽  
pp. 624-629 ◽  
Author(s):  
Noriko Kodama ◽  
Yukihito Murata ◽  
Akihiro Asakawa ◽  
Akio Inui ◽  
Masahiko Hayashi ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Antitumor Effects ◽  
Tumor Bearing

scholarly journals Antitumor effects of melanin fromLachnumYM226 and its derivative in H22 tumor-bearing mice

MedChemComm ◽  
2018 ◽  
Vol 9 (6) ◽  
pp. 1059-1068 ◽  
Author(s):  
Fang Shi ◽  
Jinglei Li ◽  
Ziyang Ye ◽  
Liuqing Yang ◽  
Tingting Chen ◽  
...  
Keyword(s):  
Antitumor Effect ◽  
Antitumor Effects ◽  
Tumor Bearing

LM and ALM showed notable antitumor effect in H22 tumor-bearing mice and ALM was more effective.

The antitumor effects of Qigong-emitted external Qi and its influence on the immunologic functions of tumor-bearing mice

1991 ◽  
Vol 11 (4) ◽  
pp. 253-256 ◽  
Author(s):  
Lei Xue-feng ◽  
Bi Ai-hua ◽  
Zhang Zhi-xiang ◽  
Cheng Zheng-yao
Keyword(s):  
Antitumor Effects ◽  
Tumor Bearing

scholarly journals Indigofera suffruticosa: An Alternative Anticancer Therapy

2007 ◽  
Vol 4 (3) ◽  
pp. 355-359 ◽  
Author(s):  
Jeymesson Raphael Cardoso Vieira ◽  
Ivone Antônia de Souza ◽  
Silene Carneiro do Nascimento ◽  
Sônia Pereira Leite
Keyword(s):  
Solid Tumors ◽  
Antitumor Effect ◽  
Anticancer Agent ◽  
Anticancer Therapy ◽  
Control Group ◽  
Aqueous Extracts ◽  
Sarcoma 180 ◽  
Antitumor Effects ◽  
Mtt Method ◽  
Low Order

Indigofera suffruticosaMill (Fabeceae) occurs in the Northeast countryside and has intensive popular use in the treatment of infectious, inflammatory and other processes. The main aim of the present work was to investigate the cytotoxic and antitumor effects of aqueous extracts of leaves ofI. suffruticosaobtained by infusion and maceration as well as to evaluate the toxicological properties. Aqueous extracts did not exhibit cytotoxicity against HEp-2 (human epidermoid cancer cell) cell lines by MTT method. From the aqueous extract by infusion, the toxicological assay showed low order of toxicity. The antitumor effect of aqueous extracts by infusion (64.53%) and maceration (62.62%) against sarcoma 180 in mice at a dose of 50 mg kg−1(intraperitoneally), based on low order of toxicity was comparable to the control group, which showed 100% development. Considering the low order of toxicity and that it is highly effective in inhibiting growth of solid tumors, the aqueous extracts of leaves ofI. suffruticosamay be used as an alternative anticancer agent.

scholarly journals Antitumor effects of ethanol extracts from Hyptis Rhomboidea in H22 tumor-bearing mice

2017 ◽  
Vol 13 (52) ◽  
pp. 571 ◽  
Author(s):  
Fang-Rong Cheng ◽  
Hong-Xin Cui ◽  
Lu Tang ◽  
Ke Yuan
Keyword(s):  
Antitumor Effects ◽  
Tumor Bearing ◽  
Ethanol Extracts
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