Osteoporosis was associated with severe abdominal aortic calcification based on a cross-sectional study

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Mingyue Wu ◽  
Yihai Liu ◽  
Chongxia Zhong ◽  
Biao Xu ◽  
Lina Kang
Keyword(s):  
Cross Sectional Study ◽  
Aortic Calcification ◽  
Sectional Study ◽  
Abdominal Aortic Calcification ◽  
Cross Sectional ◽  
Abdominal Aortic

scholarly journals Osteocalcin and Abdominal Aortic Calcification in Hemodialysis Patients: An Observational Cross-Sectional Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Fengyu Jia ◽  
Suxia Wang ◽  
Ying Jing ◽  
Hanhui Zhao ◽  
Peng Rong ◽  
...  
Keyword(s):  
Vascular Calcification ◽  
Negative Correlation ◽  
Pearson Correlation ◽  
Fibroblast Growth Factor 23 ◽  
Cross Sectional Study ◽  
Aortic Calcification ◽  
Maintenance Hemodialysis ◽  
Abdominal Aortic Calcification ◽  
Cross Sectional ◽  
Abdominal Aortic

ObjectivesTo investigate the serum level of osteocalcin (OC), also known as bone Gla protein, in maintenance hemodialysis (MHD) patients and its correlation with abdominal aortic calcification (AAC).MethodsFrom July 2017 to February 2020, we enrolled 108 adult MHD patients. Routine fasting blood laboratory tests were performed before the start of the second hemodialysis in a week. Abdominal aortic calcification score (AACs) was assessed within 1 month. Pearson correlation and Logistic regression were used to analyze the data.ResultsThe OC level was 231.56 (25.92,361.33) ng/ml, elevating significantly in this group of MHD patients. It had a positive correlation with serum phosphorus (r = 0.511, P = 0.001), intact parathyroid hormone(iPTH) (r = 0.594, P = 0.0001), fibroblast growth factor 23(FGF23) (r = 0.485, P = 0.003) and a negative correlation with age(r = -0.356, P = 0.039). Based on the AACs, patients were divided into two groups. Serum OC level were higher in patients with AACs≥5 (p=0.032). A multiple logistics regression analysis revealed that age (odds ratio [OR]1.14, P=0.005) and OC(OR=1.10, P=0.008)were risk factors for high AACs(≥5).ConclusionThe study implicated that OC elevated significantly in this group of MHD patients.OC is positively correlated with phosphorus, iPTH, FGF23, and a negative correlation with age. OC was a risk factor for vascular calcification in this study, but this study did not classify osteocalcin as c-OC and unOC. Whether unOC is associated more directly with vascular calcification requires further study.

Abdominal aortic calcification is associated with morbidity of cardiovascular disease and Fib-4 index in type 2 diabetes: a retrospective cross-sectional study

2020 ◽  
Author(s):  
Yu Togashi ◽  
Jun Shirakawa ◽  
Daisuke Miyashita ◽  
Mayu Kyohara ◽  
Tomoko Okuyama ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Cross Sectional Study ◽  
Abdominal Aortic Calcification ◽  
Cross Sectional ◽  
Abdominal Aortic ◽  
Artery Disease

Abstract Background: Little is known about the association between abdominal aortic calcification (AAC) and the risk of cardiovascular disease (CVD) among patients with diabetes. This study evaluated the cross-sectional association between AAC and CVD morbidity in patients with type 2 diabetes. Methods: This retrospective cross-sectional study enrolled 285 inpatients with type 2 diabetes. The lateral view of an abdominal X-ray image obtained while each subject was in a standing position was examined, and the AAC score and AAC length, corresponding to the area of calcific deposits in the anterior and posterior aortic wall for the L1-4 and L1-5 regions, respectively, were measured. The associations between the AAC scores and lengths and the presence of coronary artery disease (CAD), cerebral infarction (CI), and peripheral artery disease (PAD) were then assessed. The correlation between the AAC grades and other clinical factors were also evaluated. Results: The degree of AAC was significantly correlated with a higher prevalence of CAD and CI but not PAD after adjustments for cardiovascular risk factors. The AAC score was inversely correlated with BMI, and both the AAC score and the AAC length were correlated with the Fib-4 index; these correlations persisted after adjustments for cardiovascular risk factors and BMI, although AAC was not associated with ultrasonography-diagnosed fatty liver. Conclusion: AAC is associated with CAD and CI morbidity in patients with type 2 diabetes. AAC grading also predicts the Fib-4 index, a hepatic fibrosis marker, suggesting a novel potential predictor of liver disease that is independent of cardiovascular risk factors and obesity.

Further evidence on the relationship between abdominal aortic aneurysm and periodontitis: A cross‐sectional study

2020 ◽  
Vol 91 (11) ◽  
pp. 1453-1464
Author(s):  
Leila Salhi ◽  
Natzi Sakalihasan ◽  
Ambre Gau Okroglic ◽  
Nicos Labropoulos ◽  
Laurence Seidel ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Abdominal Aortic ◽  
The Relationship

scholarly journals Associations between serum triglycerides and abdominal aortic calcification in a cross-sectional study from the United States of America

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
P Penson ◽  
S Javed ◽  
M Banach ◽  
G Y H Lip
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Strong Relationship ◽  
Aortic Calcification ◽  
Medicine Use ◽  
Point Scale ◽  
Abdominal Aortic Calcification ◽  
Cross Sectional ◽  
Abdominal Aortic

Abstract Background Abdominal aortic calcification (AAC) has recently been recognised as a risk factor for cardiovascular disease, as it shares pathophysiological mechanisms with coronary artery disease. Purpose We investigated relationships between AAC and traditional cardiovascular risk factors in a cross-sectional epidemiological cohort from the USA Methods We used data from the National Health and Nutrition Evaluation Survey (NHANES) from the years 2103–2014. Dual-energy X-ray absorptiometry (DXA scans) were performed for a subset of 3140 NHANES participants over the age of 40. The images were scored according to ACC-24, a 24-point scale. We performed binary logistic regression to investigate relationships between demographic variables (age, sex, poverty income ratio, & educational status) CV risk factors (triglycerides (fasting, and non-fasting) LDL-C, HDL-C systolic blood pressure, body mass index, smoking status & diabetes) medicine use (statins, antihypertensives and antiplatelets) and AAC status (patients with a score ≥2 on the 24-point scale were considered AAC positive). Non normally-distributed variables were categorised for the purposes of analysis. Results Participants with AAC were older (mean 65.5 years ± SD 11.7) than unaffected individuals (56.1±11.1) AAC was also associated with higher BMI (28.7±5.8 v. 27.6±4.8 kg/m2), and higher systolic blood pressure (131.3±19.5 v 125.8±18.4 mmHg). We found a strong relationship between plasma triglyceride concentrations and AAC. In univariate analysis, fasting triglycerides above the first quartile were associated with approximately double the risk of AAC, compared to those in the first quartile (see table). This relationship persisted when the analysis was adjusted for demographics, risk factors and medicine use. A similar pattern was seen with non-fasting triglycerides (see table). Conclusions We found a strong relationship between triglycerides and AAC. Further work is required to determine whether this observation can be validated in other cohorts, and whether interventions to reduce triglyceides can alter the progression of AAC. FUNDunding Acknowledgement Type of funding sources: None. Odds ratios (95% CI) for AAC

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