Fabrication of multifunctional chitosan-Guar-Aloe Vera gel to promote wound healing

2021 ◽  
Author(s):  
Mojtaba Ansari ◽  
Heidar Meftahizadeh ◽  
Hossein Eslami
Keyword(s):  
Wound Healing ◽  
Aloe Vera ◽  
Promote Wound Healing ◽  
Aloe Vera Gel

scholarly journals Efficacy of Aloe vera Gel on the Excision Wound Healing in Sprague dawley Rats

2021 ◽  
Vol 4 (1) ◽  
pp. 46-49
Author(s):  
Bagus Uda Palgunadi ◽  
Asih Rahayu ◽  
Yos Adi Prakoso
Keyword(s):  
Wound Healing ◽  
Aloe Vera ◽  
Sprague Dawley ◽  
Excision Wound ◽  
Promote Wound Healing ◽  
Living Things ◽  
Aloe Vera Gel ◽  
Sprague Dawley Rats ◽  
Better Than

Wound is a pathological processes in all living things. Wound includes the overlapping mechanisms. The failure in wound healing causes infection. This study aimed to analyze the efficacy of Aloe vera gel in excisionwound on the rat’s back. This study used 18 male, Sprague Dawley rats, and they were induced excision wound on the back. The rats were separated into 3 groups, K1 = control, K2 = treated with betadin gel, K3 = treated with Aloe vera gel. The therapy was given twice a day for 7 days. The wound measurement was observed in day 3 and 7. The data were analyzed using SPSS. The result showed that Aloe vera gel potentially promote wound healing through the decrease microscopical condition of wound, re-epithelialization, and deposition of collagen better than in group K1 and K2 (p≤0.05). In conclusion, Aloe vera gel promote excision wound healing in Sprague Dawley rats.

Nanosuspension-Based Aloe vera Gel of Silver Sulfadiazine with Improved Wound Healing Activity

2017 ◽  
Vol 18 (8) ◽  
pp. 3274-3285 ◽  
Author(s):  
Md Abul Barkat ◽  
Harshita ◽  
Iqbal Ahmad ◽  
Raisuddin Ali ◽  
Satya Prakash Singh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Aloe Vera ◽  
Silver Sulfadiazine ◽  
Aloe Vera Gel ◽  
Wound Healing Activity

scholarly journals The Effect of Aloe vera (Linn) On Cutaneous Wound Healing and Wound Contraction Rate in Adult Rabbits

2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Martha Orendu Attah ◽  
Tonye Watson Jacks ◽  
Attah Jacob ◽  
Otong Eduitem ◽  
Barnabas John
Keyword(s):  
Wound Healing ◽  
Aloe Vera ◽  
Wound Contraction ◽  
Control Group ◽  
Cutaneous Wound Healing ◽  
Contraction Rate ◽  
Wound Area ◽  
Cutaneous Wound ◽  
Cutaneous Wounds ◽  
Aloe Vera Gel

Background: In the present research study, the rate of cutaneous wound healing and contraction rate in healthy rabbits using Aloe vera pulp was studied.Methods: Ten healthy rabbits were used for the study. They were divided into two groups consisting of five rabbits each. Cutaneous wounds were made on the lumbar region of each rabbit using a template which ensured that the wounds were of the same size in all the rabbits. 5ml of Aloe vera gel was applied to the wounds of the animals in the test group, while nothing was applied to the wound area of the animals in the control group. The wound area in each group was measured for a period of 21 days, using a venire caliper and tracing paper which was used to trace the wound area. Tissue samples were removed from the wound area in both experimental and control groups and subjected to routine histological analysis, also, morphometric analysis was performed.Results: The rate of wound contraction and mean centripetal contraction was calculated in both groups and graphically represented using Microsoft Excel. The results showed that animals who were treated with Aloe vera gel had a greater wound contraction rate, as well as rapid wound closure. The micrographs showed a thicker epithelial layer, with thinner collagen fibers in the dermis of experimental animals compared to the control group. There was also an abundant capillary bed at the dermal-epidermal junction in the experimental group, compared to the control group.Conclusion:  Aloe vera may increase the rate of wound healing by accelerating epithelial migration, and may also play a role in neo-vascularization of the newly healed area.Keywords: Aloe vera, Cutaneous Wounds, Rabbits, Wound Contraction, Wound Healing

Does Aloe vera promote wound healing?

2018 ◽  
Vol 21 (8) ◽  
pp. 10-11
Author(s):  
Anuradha Ranganath ◽  
Jessie A. Junker
Keyword(s):  
Wound Healing ◽  
Aloe Vera ◽  
Promote Wound Healing

scholarly journals A Comparative Study of the Effects of Nigella sativa Oil Gel and Aloe Vera Gel on Wound Healing in Diabetic Rats

2018 ◽  
Vol 23 ◽  
pp. 2515690X1877280 ◽  
Author(s):  
Yunita Sari ◽  
Iwan Purnawan ◽  
Dhadhang Wahyu Kurniawan ◽  
Eman Sutrisna
Keyword(s):  
Wound Healing ◽  
Nigella Sativa ◽  
Wound Care ◽  
Aloe Vera ◽  
Diabetic Rats ◽  
The Other ◽  
Diabetic Ulcers ◽  
Nigella Sativa Oil ◽  
Aloe Vera Gel ◽  
Important Evidence

Clinicians and wound care nurses in Indonesia usually use Nigella sativa oil (NSO) gel and aloe vera (AV) gel to treat diabetic ulcers. However, there are no studies directly comparing the effects of NSO and AV gels on wound healing, so it is unknown which of these 2 plants is better at promoting wound healing in diabetic ulcers. If the comparative efficacy between these 2 gels was known, it would be important evidence favoring the clinical use of one or the other product in Indonesia. The aim of this study was to investigate and compare the effectiveness of NSO and AV gels on wound healing in a rat model of diabetic ulcers. This experimental study involved 3 groups: NSO gel, AV gel, and controls. Our study showed that from day 5 onward, necrotic tissue and inflammation decreased in the AV gel group compared with the other groups. The wound areas on days 6 ( P = .020) and 7 ( P = .021) were significantly smaller in the AV gel group than in the NSO gel group. Reepithelialization was also better in the AV gel group than in the other groups. This is the first study to compare the effects of AV and NSO gels on wound healing in diabetic ulcers. Our study indicates that the AV gel is better than the NSO gel. Therefore, it is recommended that clinicians and wound care nurses use AV gel instead of NSO gel for the topical treatment of diabetic ulcers.

scholarly journals Aloe Gel Enhances Angiogenesis in Healing of Diabetic Wound

2011 ◽  
Vol 3 (3) ◽  
pp. 204
Author(s):  
Djanggan Sargowo ◽  
Adeodatus Yuda Handaya ◽  
Mohammad Aris Widodo ◽  
Diana Lyrawati ◽  
Askandar Tjokroprawiro
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Wistar Rats ◽  
Aloe Vera ◽  
Diabetic Rats ◽  
Diabetic Wound ◽  
Aloe Vera Gel ◽  
Diabetic Wound Healing ◽  
Aloe Gel ◽  
Oxide Synthase

BACKGROUND: Diabetic micro and macroangiophathy lead to the incident of diabetic foot ulcers characterized by an increased number of circulating endothelial cells (CECs) and decreased function of endothelial progenitor cells (EPCs). This fact is correlated with ischemia and diabetic wound healing failure. Aloe vera gel is known to be able to stimulate vascular endothelial growth factor (VEGF) expression and activity by enhancing nitric oxide (NO) production as a result of nitric oxide synthase (NOS) enzyme activity. Aloe vera is a potential target to enhancing angiogenesis in wound healing.OBJECTIVE: The objective of this study was to explore the major role of Aloe vera gel in wound healing of diabetic ulcers by increasing the level of EPCs, VEGF, and endothelial nitric oxide synthase (eNOS), as well as by reducing the level of CECs involved in angiogenesis process of diabetic ulcers healing.METHODS: The experimental groups was divided into five subgroups consisting of non diabetic wistar rats, diabetic rats without oral administration of aloe gel, and treatment subgroup (diabetic rats) with 30, 60 and 120 mg/day of aloe gel doses for 14 days. All subgroups were wounded and daily observation was done on the wounds areas. Measurement of the number of EPCs (CD34), and CECs (CD45 and CD146) was done by flowcytometry, followed by measurement of VEGF and eNOS expression on dermal tissue by immunohistochemical method on day 0 and day 14 after treatment. The quantitative data were analyzed by One-Way ANOVA and Linear Regression, with a cofidence interval 5% and significance level (p<0.05) using SPSS 16 software to compare the difference and correlation between wound diameters, number of EPCs and CECs as well as the levels of VEGF and eNOS.RESULTS: The results of this study showed that aloe gel oral treatment in diabetic wistar rats was able to accelerate the wound healing process. It was shown by significant reduction of wound diameter (0.27±0.02); the increased number of CECs (0.42±0.57), respectively (p<0.05). On the other hand, the wound diameter and eNOS indicators showed significant differences at the dose of 60 mg, while the number of EPCs and CECs and the level of VEGF showed significantly different results at a dose of 120 mg. Aloe gel oral therapy showed a positive indication of wound healing acceleration at the optimum dose range 60-120 mg a day.CONCLUSIONS: Aloe gel is potential to be a herbal therapy candidate for diabetic wound healing through enhancing EPCs homing, decreasing the CECs number, and stimulating the increase of VEGF and eNOS levels,hence proving to be a dominant factor in the angiogenesis process.KEYWORDS: aloe gel, diabetes, wound healing, angiogenesis

scholarly journals A comparative study between aloe vera gel dressing and conventional dressing in chronic wounds

2017 ◽  
Vol 4 (10) ◽  
pp. 3427
Author(s):  
Virendra S. Athavale ◽  
Shivmurti N. Khandalkar ◽  
Megha Mahawar ◽  
Iresh Shetty ◽  
Aditya Lad
Keyword(s):  
Wound Healing ◽  
Surface Area ◽  
Chronic Wounds ◽  
Average Rate ◽  
Aloe Vera ◽  
Cost Effective ◽  
Control Group ◽  
Percentage Reduction ◽  
Aloe Vera Gel ◽  
Group A

Background: The aim of this study was to evaluate the effectiveness and rate of healing of Aloe vera gel in treatment of chronic wounds, to compare the effectiveness of Aloe vera gel with conventional dressing (normal saline and povidone iodine) and to assess the percentage reduction of wound healing with Aloe vera gel dressing.Methods: The study was conducted at Dr. D. Y. Patil Medical College and Hospital, DPU University, for a period of 2 months (from January 2017 to March 2017) and is a prospective and comparative randomized type of study using 50 cases (Group A and Group B, 25 each). The study was approved by the Institute’s Ethics Committee.Results: Data analysis showed that at the end of 4 weeks, mean surface area in Group A is reduced to 4.58 cm2 from 9.79 cm2 which is higher than that in the control group. Also, the average rate of healing in Aloe vera gel is more than control group. Percentage reduction in ulcer surface area was calculated to be much more in Group A as compared to Group B.Conclusions: The study concluded that Aloe vera gel is highly effective in treatment of chronic ulcers and stimulates the growth of wound healing. Thus, reducing the hospital stay. Apart from being efficacious in wound healing, Aloe vera gel is safe product. No allergic reactions/infections were associated with Aloe vera gel. Aloe vera gel not only heals faster but is also cost effective.

scholarly journals Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride

2020 ◽  
Vol 35 (5) ◽  
Author(s):  
Adriana Yuriko Koga ◽  
Julio César Felix ◽  
Rodrigo Gomes Marques Silvestre ◽  
Leandro Cavalcante Lipinski ◽  
Bruna Carletto ◽  
...  
Keyword(s):  
Wound Healing ◽  
Zinc Chloride ◽  
Aloe Vera ◽  
Healing Effect ◽  
Aloe Vera Gel ◽  
Wound Healing Effect
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