Molecular basis of lung tissue regeneration

2011 ◽  
Vol 59 (4) ◽  
pp. 231-244 ◽  
Author(s):  
Hiroshi Kubo
Keyword(s):  
Tissue Regeneration ◽  
Lung Tissue ◽  
Molecular Basis

scholarly journals Feasibility of nano-scaffold for Covid-19 infected lung tissue regeneration: A review

2021 ◽  
Vol 7 (3) ◽  
pp. 118-125
Author(s):  
K. Jeevika ◽  
R. A. Sobiya ◽  
T. Indhumathi ◽  
S. Kathiravan
Keyword(s):  
Tissue Regeneration ◽  
Lung Tissue

scholarly journals Hedgehog proteins create a dynamic cholesterol interface

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246814 ◽  
Author(s):  
Amirhossein Mafi ◽  
Rahul Purohit ◽  
Erika Vielmas ◽  
Alexa R. Lauinger ◽  
Brandon Lam ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Sonic Hedgehog ◽  
Tissue Regeneration ◽  
Molecular Basis ◽  
Signaling Proteins ◽  
Full Structure ◽  
Hedgehog Proteins ◽  
Hh Signaling ◽  
Dynamics Simulations ◽  
Photoaffinity Crosslinking

During formation of the Hedgehog (Hh) signaling proteins, cooperative activities of the Hedgehog INTein (Hint) fold and Sterol Recognition Region (SRR) couple autoproteolysis to cholesterol ligation. The cholesteroylated Hh morphogens play essential roles in embryogenesis, tissue regeneration, and tumorigenesis. Despite the centrality of cholesterol in Hh function, the full structure of the Hint-SRR (“Hog”) domain that attaches cholesterol to the last residue of the active Hh morphogen remains enigmatic. In this work, we combine molecular dynamics simulations, photoaffinity crosslinking, and mutagenesis assays to model cholesterolysis intermediates in the human Sonic Hedgehog (hSHH) protein. Our results provide evidence for a hydrophobic Hint-SRR interface that forms a dynamic, non-covalent cholesterol-Hog complex. Using these models, we suggest a unified mechanism by which Hh proteins can recruit, sequester, and orient cholesterol, and offer a molecular basis for the effects of disease-causing hSHH mutations.

Lung tissue regeneration after induced injury in Runx3 KO mice

2010 ◽  
Vol 341 (3) ◽  
pp. 465-470 ◽  
Author(s):  
Jong-Min Lee ◽  
Hyuk-Jae Kwon ◽  
Suk-Chul Bae ◽  
Han-Sung Jung
Keyword(s):  
Tissue Regeneration ◽  
Lung Tissue

scholarly journals Comparative Aspects of Annelid Regeneration: Towards Understanding the Mechanisms of Regeneration

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1148
Author(s):  
Roman P. Kostyuchenko ◽  
Vitaly V. Kozin
Keyword(s):  
Tissue Regeneration ◽  
Molecular Basis ◽  
The Other ◽  
Whole Body ◽  
Descriptive Data ◽  
Transcriptomic Data ◽  
Levels Of Organization ◽  
Ability To Regenerate ◽  
Different Levels

The question of why animals vary in their ability to regenerate remains one of the most intriguing questions in biology. Annelids are a large and diverse phylum, many members of which are capable of extensive regeneration such as regrowth of a complete head or tail and whole-body regeneration, even from few segments. On the other hand, some representatives of both of the two major annelid clades show very limited tissue regeneration and are completely incapable of segmental regeneration. Here we review experimental and descriptive data on annelid regeneration, obtained at different levels of organization, from data on organs and tissues to intracellular and transcriptomic data. Understanding the variety of the cellular and molecular basis of regeneration in annelids can help one to address important questions about the role of stem/dedifferentiated cells and “molecular morphallaxis” in annelid regeneration as well as the evolution of regeneration in general.

scholarly journals Resolvin D1 prevents smoking-induced emphysema and promotes lung tissue regeneration

2016 ◽  
pp. 1119 ◽  
Author(s):  
Sei Won Lee ◽  
Kang-Hyun Kim ◽  
Tai Sun Park ◽  
You-Sun Kim ◽  
Jae Seung Lee ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Lung Tissue ◽  
Resolvin D1

scholarly journals The Potential Contribution of Biopolymeric Particles in Lung Tissue Regeneration of COVID-19 Patients

Polymers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 4011
Author(s):  
Mohamed Abbas ◽  
Mohammed S. Alqahtani ◽  
Hussain M. Almohiy ◽  
Fawaz F. Alqahtani ◽  
Roaa Alhifzi ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Lung Tissue ◽  
Effective Means ◽  
Airway Epithelial Cells ◽  
Lung Cells ◽  
Potential Contribution ◽  
Airway Epithelial ◽  
Structural Components ◽  
Diagnostic Agents ◽  
Long Time

The lung is a vital organ that houses the alveoli, which is where gas exchange takes place. The COVID-19 illness attacks lung cells directly, creating significant inflammation and resulting in their inability to function. To return to the nature of their job, it may be essential to rejuvenate the afflicted lung cells. This is difficult because lung cells need a long time to rebuild and resume their function. Biopolymeric particles are the most effective means to transfer developing treatments to airway epithelial cells and then regenerate infected lung cells, which is one of the most significant symptoms connected with COVID-19. Delivering biocompatible and degradable natural biological materials, chemotherapeutic drugs, vaccines, proteins, antibodies, nucleic acids, and diagnostic agents are all examples of these molecules‘ usage. Furthermore, they are created by using several structural components, which allows them to effectively connect with these cells. We highlight their most recent uses in lung tissue regeneration in this review. These particles are classified into three groups: biopolymeric nanoparticles, biopolymeric stem cell materials, and biopolymeric scaffolds. The techniques and processes for regenerating lung tissue will be thoroughly explored.

Lung tissue viscoelasticity: a mathematical framework and its molecular basis

1994 ◽  
Vol 76 (6) ◽  
pp. 2749-2759 ◽  
Author(s):  
B. Suki ◽  
A. L. Barabasi ◽  
K. R. Lutchen
Keyword(s):  
Lung Tissue ◽  
Power Law ◽  
Molecular Basis ◽  
Relaxation Function ◽  
Soft Tissues ◽  
Angular Frequency ◽  
Mathematical Framework ◽  
Tissue Impedance ◽  
Polymer Systems ◽  
Mechanistic Basis

Recent studies indicated that lung tissue stress relaxation is well represented by a simple empirical equation involving a power law, t-beta (where t is time). Likewise, tissue impedance is well described by a model having a frequency-independent (constant) phase with impedance proportional to omega-alpha (where omega is angular frequency and alpha is a constant). These models provide superior descriptions over conventional spring-dashpot systems. Here we offer a mathematical framework and explore its mechanistic basis for using the power law relaxation function and constant-phase impedance. We show that replacing ordinary time derivatives with fractional time derivatives in the constitutive equation of conventional spring-dashpot systems naturally leads to power law relaxation function, the Fourier transform of which is the constant-phase impedance with alpha = 1 - beta. We further establish that fractional derivatives have a mechanistic basis with respect to the viscoelasticity of certain polymer systems. This mechanistic basis arises from molecular theories that take into account the complexity and statistical nature of the system at the molecular level. Moreover, because tissues are composed of long flexible biopolymers, we argue that these molecular theories may also apply for soft tissues. In our approach a key parameter is the exponent beta, which is shown to be directly related to dynamic processes at the tissue fiber and matrix level. By exploring statistical properties of various polymer systems, we offer a molecular basis for several salient features of the dynamic passive mechanical properties of soft tissues.

scholarly journals 4427 Angiopoietin F-domain valency determines outcome of Tie2 receptor engagement and accelerates angiogenesis in tissue regeneration

2020 ◽  
Vol 4 (s1) ◽  
pp. 2-2
Author(s):  
Yan Ting Zhao ◽  
Jorge Fallas ◽  
Shally Saini ◽  
George Ueda ◽  
Logeshwaran Somasundaram ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tissue Regeneration ◽  
Molecular Basis ◽  
Umbilical Vein ◽  
Organ Transplant ◽  
Tube Formation ◽  
New Paradigm ◽  
Tie2 Receptor ◽  
Wide Range

OBJECTIVES/GOALS: Lack of blood vessels remains a major obstacle in tissue regeneration. Angiopoietin 1 and 2 modulate angiogenesis through the Tie2 receptor tyrosine kinase. Ang1 activates pAKT to promote endothelial cell survival while Ang2 antagonizes these effects. We aim to dissect the Ang/Tie2 pathway to uncover the molecular basis for these opposing effects. METHODS/STUDY POPULATION: Ang1 and Ang2 bind Tie2 via nearly identical F-domains (Fd). To investigate the molecular basis regulating the Tie2 pathway, we generated a series of computationally designed self-assembling protein scaffolds presenting F-domains in a wide range of valencies and geometries using Rosette Molecular Modeling Suite. We examined the protein kinase activation, cell migration, and blood vessel formation produced by the designed proteins in human umbilical vein endothelial cells. RESULTS/ANTICIPATED RESULTS: Two phenotypic classes were demonstrated by the number of presented F domains: scaffolds presenting 3 or 4 Fd have Ang2 like activity, upregulating pFAK and pERK but not pAKT and failing to induce cell migration and tube formation; scaffolds presenting more than 6 Fd have Ang1 like activity, upregulating the three signaling branches and enhancing cell migration and tube formation. Scaffolds with 8 or more Fd show superagonist activity, producing significantly stronger phenotypes than Ang1. These results suggest that Fd valency largely determines Ang1 vs Ang2 signaling outcomes, and our designed superagonists can outperform Ang1 in vascularization and wound healing. In in vivo experiments, nanoparticles displaying 60 copies of Fd produce significant revascularization in hemorrhagic brains. DISCUSSION/SIGNIFICANCE OF IMPACT: Targeting the Tie2 pathway is a new paradigm in regenerative medicine. Our designed constructs will enable us to generate high-affinity Tie2 agonists and antagonists as drugs to control angiogenesis, enabling tissue regeneration that recapitulates the biological architecture of the native tissue physiology, improving organ transplant outcome.

Renilla Bioluminescence: A Morphologic Approach to the Location of Photocytes

1974 ◽  
Vol 32 ◽  
pp. 208-209
Author(s):  
Ben O. Spurlock ◽  
Milton J. Cormier
Keyword(s):  
Excited State ◽  
Ground State ◽  
Molecular Basis ◽  
Light Emission ◽  
Chemical Basis ◽  
Electronic Excited State ◽  
Colonial Form ◽  
The Common ◽  
Eighteenth And Nineteenth Centuries ◽  
Catalyzed Oxidation

The phenomenon of bioluminescence has fascinated layman and scientist alike for many centuries. During the eighteenth and nineteenth centuries a number of observations were reported on the physiology of bioluminescence in Renilla, the common sea pansy. More recently biochemists have directed their attention to the molecular basis of luminosity in this colonial form. These studies have centered primarily on defining the chemical basis for bioluminescence and its control. It is now established that bioluminescence in Renilla arises due to the luciferase-catalyzed oxidation of luciferin. This results in the creation of a product (oxyluciferin) in an electronic excited state. The transition of oxyluciferin from its excited state to the ground state leads to light emission.

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