Complementary and Comparative Study on Hypoglycemic and Antihyperglycemic Activity of Various Extracts of Eugenia jambolana Seed, Momordica charantia Fruits, Gymnema sylvestre, and Trigonella foenum graecum Seeds in Rats

2009 ◽  
Vol 160 (8) ◽  
pp. 2388-2400 ◽  
Author(s):  
Mukesh Yadav ◽  
Amita Lavania ◽  
Radha Tomar ◽  
G. B. K. S. Prasad ◽  
Shalini Jain ◽  
...  
Keyword(s):  
Comparative Study ◽  
Momordica Charantia ◽  
Gymnema Sylvestre ◽  
Antihyperglycemic Activity ◽  
Trigonella Foenum Graecum ◽  
Eugenia Jambolana

scholarly journals Best herbs for managing diabetes: a review of clinical studies

2013 ◽  
Vol 49 (3) ◽  
pp. 413-422 ◽  
Author(s):  
Ahmad Ghorbani
Keyword(s):  
Clinical Studies ◽  
Animal Studies ◽  
Nigella Sativa ◽  
Public Health Problem ◽  
Momordica Charantia ◽  
Ocimum Sanctum ◽  
Diabetic Patients ◽  
Gymnema Sylvestre ◽  
Silybum Marianum ◽  
Trigonella Foenum Graecum

Diabetes mellitus is a public health problem which leads to serious complications over time. Experimentally, many herbs have been recommended for treating diabetes. In most cases, however, the recommendations are based on animal studies and limited pieces of evidence exist about their clinical usefulness. This review focused on the herbs, the hypoglycemic actions of which have been supported by three or more clinical studies. The search was done in Google Scholar, Medline and Science Direct databases using the key terms diabetes, plants, herbs, glucose and patients. According to the clinical studies, Aegle marmelos, Allium cepa, Gymnema sylvestre, Momordica charantia, Ocimum sanctum, Nigella sativa, Ocimum sanctum, Panax quinquefolius, Salacia reticulate, Silybum marianum and Trigonella foenum-graecum have shown hypoglycemic and, in some cases, hypolipidemic activities in diabetic patients. Among them, Gymnema sylvestre, Momordica charantia, Silybum marianum and Trigonella foenum-graecum have acquired enough reputation for managing diabetes. Thus, it seems that physicians can rely on these herbs and advise for the patients to improve management of diabetes.

Amelioration of Streptozotocin induced hyperglycemia in rats using combination of Gymnema sylvestre and Eugenia jambolana plant extracts

2021 ◽  
Vol 45 (1) ◽  
pp. 42-48
Author(s):  
C. Nagabhushan ◽  
Suguna Rao ◽  
M.L. Satyanarayana ◽  
G. Leena ◽  
C.R. Santhosh
Keyword(s):  
Plant Extracts ◽  
Gymnema Sylvestre ◽  
Eugenia Jambolana

In vitro anthelmintic and antioxidant potential of fruits of Momordica charantia: A comparative study

2014 ◽  
Vol 7 (2) ◽  
pp. 113
Author(s):  
Saikat Sen ◽  
Bitul Borah ◽  
Raja Chakraborty ◽  
BK Dey ◽  
BJ Sahariah ◽  
...  
Keyword(s):  
Comparative Study ◽  
Momordica Charantia ◽  
Antioxidant Potential

New olean-15-ene type gymnemic acids from Gymnema sylvestre (Retz.) R.Br. and their antihyperglycemic activity through α-glucosidase inhibition

2019 ◽  
Vol 32 ◽  
pp. 83-89 ◽  
Author(s):  
Naila Hassan Ali Alkefai ◽  
Saima Amin ◽  
Manju Sharma ◽  
Javed Ahamad ◽  
Showkat R. Mir
Keyword(s):  
Gymnema Sylvestre ◽  
Antihyperglycemic Activity

scholarly journals Diyabette Kullanılan Bitkisel Desteklerin Etkinliği ve Güvenilirliği

2019 ◽  
Vol 47 ◽  
pp. 110-117
Author(s):  
Ezgi Bellikci Koyu
Keyword(s):  
Nigella Sativa ◽  
Zingiber Officinale ◽  
Urtica Dioica ◽  
Momordica Charantia ◽  
Trigonella Foenum Graecum ◽  
Zingiber Officinale Roscoe ◽  
Trigonella Foenum Graecum L

Bitkiler uzun yüzyıllar boyunca tedavinin en önemli parçası olmuşlardır. On dokuzuncu yüzyılda kimya alanında önemli gelişmelerin olması ve ilaç moleküllerinin keşfi ile bitkilerin tıbbi amaçlı kullanımları giderek azalsa da, son yıllarda doğaya dönüş çabaları içerisinde kullanımlarında yeniden bir artış gözlenmektedir. Özellikle diyabet gibi kronik seyirli hastalıklarda modern tedaviye destek olarak bu ürünlerin kullanımları sıklıkla tercih edilmektedir. Bu ilgiye paralel olarak son yıllarda bitkilerin diyabet tedavisindeki etkisini araştıran klinik çalışmalar da artmaya başlamıştır. Etkinliğin yanı sıra bitkilerin güvenilir kullanımları da son derece önemlidir. Doğru bitkinin kullanımı, kullanılan ürünün bileşimi, kalitesi, hazırlama yöntemi, yan etkileri, ilaç etkileşimleri ve kontraendikasyonları da tedavi sürecini etkileyen ve güvenilir kullanım için göz önünde bulundurulması gereken faktörlerdir. Bu derlemede tarçın (Cinnamomum sp.), çörek otu (Nigella sativa L.), kudret narı (Momordica charantia L.), çemen otu (Trigonella foenum-graecum L.), zencefil (Zingiber officinale Roscoe) ve ısırgan otu (Urtica dioica L.) gibi diyabet tedavisinde sıklıkla tercih edilen bitkilerin etkinliği ve güvenilirliği değerlendirilmiştir.

scholarly journals Evaluation of Antidiabetic Activity of a Novel Polyherbal Preparationagainst Streptozotocin Induced Diabetes Rat Model

2021 ◽  
pp. 42-54
Author(s):  
K. Jyothsna Jayaraju ◽  
B. Mohammed Ishaq
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Antidiabetic Activity ◽  
Gymnema Sylvestre ◽  
Standard Drug ◽  
Glucose Levels ◽  
Vinca Rosea ◽  
Eugenia Jambolana ◽  
Whole Plant

Background: Diabetes Mellitus is a chronic disorder characterised by abnormally elevated glucose levels in the blood. Diabetes is caused by one of two mechanisms: insufficient insulin synthesis (which is produced by the pancreas and reduces blood glucose) or insufficient response of cells to insulin action. The current aim of this research project was to formulate and evaluate the Polyherbal preparation (PHP) of the plants constituted with Cinnamonum zeylanicium (CJ) bark, Eugenia jambolana (EJ) seeds, Vinca rosea (VR) whole plant, Gymnema sylvestre (GS) leaves and determination of the anti-diabetic potential of the formulation in the animal model induced by Streptozotocin. Methods: Plant components in the current study used were Cinnamonum zeylanicium (CJ) bark, Eugenia jambolana (EJ) seeds, Vinca rosea (VR) whole plant, Gymnema sylvestre (GS) leaves were collected.Using a hydroalcoholic solvent, physico-chemical parameters and active chemical constituents were evaluated. The active components present in the extracts were identified by Preliminary phytochemical screening. The PHP acute toxicity analysis was conducted in compliance with OECD Guideline 423, with 200 mg/kg and 4000 mg/kg administered orally to rats over 28 days. Results: Diabetes was induced by STZ and treated with PHF did not show any alterations in behavior and no mortality was observed up to the 2000 mg/kg dose level during the interventional period. By oral administration of PHP with a dosage of 200 and 400 mg/kg, OGTT resulted in a steady decrease in blood glucose levels of 68.74±4.63 mg/dl and 63.83±1.74 mg/dl at 180min after the trial which proves that PHP possess anti-diabetic activity. By mixing each extract in varying proportions, PHP was developed and evaluated. PHP (200 and 400mg/kg) antidiabetic activity wasdetermined for streptozotocin (STZ)-induced diabetes in rats and glibenclamide (5.0mg/kg body weight) was used as a standard drug.The investigational drug was administered for 28 days and the blood glucose level effect of the PHP was analysed on the 28th day after the intervention time. Conclusion: The experimental study showed that a persistent and substantial decrease in the average blood glucose level of diabetic rats was observed with repeated administration of PHP and glibenclamide for 28 days. PHP demonstrated substantial antidiabetic and antihyperlipidemic activity similar to the standard drug. The formulation will emerge as a possible mixture that may challenge the synthetic drug.

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