Natural Compounds: DNA Methyltransferase Inhibitors in Oral Squamous Cell Carcinoma

2015 ◽  
Vol 177 (3) ◽  
pp. 577-594 ◽  
Author(s):  
Meenakshi Jha ◽  
Ruchi Aggarwal ◽  
Abhimanyu Kumar Jha ◽  
Anju Shrivastava
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Dna Methyltransferase ◽  
Natural Compounds ◽  
Dna Methyltransferase Inhibitors

scholarly journals Promoter Region Hypermethylation and mRNA Expression ofMGMTandp16Genes in Tissue and Blood Samples of Human Premalignant Oral Lesions and Oral Squamous Cell Carcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Vikram Bhatia ◽  
Madhu Mati Goel ◽  
Annu Makker ◽  
Shikha Tewari ◽  
Alka Yadu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Mrna Expression ◽  
Squamous Cell ◽  
Promoter Methylation ◽  
Dna Methyltransferase ◽  
Oral Lesions ◽  
Tissue Samples ◽  
Blood Samples

Promoter methylation and relative gene expression of O6-methyguanine-DNA-methyltransferase (MGMT) andp16genes were examined in tissue and blood samples of patients with premalignant oral lesions (PMOLs) and oral squamous cell carcinoma (OSCC). Methylation-specific PCR and reverse transcriptase PCR were performed in 146 tissue and blood samples from controls and patients with PMOLs and OSCC. In PMOL group, significant promoter methylation ofMGMTandp16genes was observed in 59% (P=0.0010) and 57% (P=0.0016) of tissue samples, respectively, and 39% (P=0.0135) and 33% (P=0.0074) of blood samples, respectively. Promoter methylation of both genes was more frequent in patients with OSCC, that is, 76% (P=0.0001) and 82% (P=0.0001) in tissue and 57% (P=0.0002) and 70% (P=0.0001) in blood, respectively. Significant downregulation ofMGMTandp16mRNA expression was observed in both tissue and blood samples from patients with PMOLs and OSCC. Hypermethylation-induced transcriptional silencing ofMGMTandp16genes in both precancer and cancer suggests important role of these changes in progression of premalignant state to malignancy. Results support use of blood as potential surrogate to tissue samples for screening or diagnosing PMOLs and early OSCC.

scholarly journals Anthocyanins: Promising Natural Compounds for Prevention and Treatment of Oral Squamous Cell Carcinoma

2020 ◽  
Vol 7 (4) ◽  
Author(s):  
Sara Pourshahidi ◽  
Mohaddeseh Davari
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Natural Compounds ◽  
Pharmaceutical Products ◽  
In Vivo Studies ◽  
Study Results ◽  
Prevention And Treatment

Background: Oral squamous cell carcinoma (OSCC) is the most common oral cancer. In recent decades, numerous studies have focused on the effects of new herbal and natural bioactive substances or pharmaceutical products on different cancer types. Some investigations have shown that anthocyanins can inhibit carcinogenesis in various ways, and some others focused on the effects of anthocyanins on squamous cell carcinoma (SCC). Methods: An electronic search of the literature was carried out in PubMed, Web of Science, and Scopus databases using the keywords “anthocyanins” and “oral cancer” or “oral squamous cell carcinoma”. Articles relevant to our topic (except for review articles) were included in this study. Results: The reviewed articles showed the inhibitory and suppressive effects of anthocyanins on OSCC, which were exerted by inhibiting NF-κB, p-Akt/PI3k, and JAK/STAT3 pathways, the induction of caspase-1 and caspase-3 overexpression, pyroptosis, mitochondrial-mediated apoptosis, and reduction of expression and production of matrix metalloproteinases and urokinase-type plasminogen activator. Conclusions: Based on the results, the anti-proliferative and apoptotic effects of anthocyanins on OSCC were dominant. Their antimetastatic effect was also reported. Therefore, anthocyanins seem to be promising natural compounds for the prevention and treatment of OSCC. In vivo studies and clinical trials are recommended to further confirm these results.

scholarly journals Metilasi DNA dan Mukosa Mulut

2019 ◽  
Vol 2 (2) ◽  
pp. 99-105
Author(s):  
Nanan Nuraeny ◽  
Dzulfikal DL Hakim ◽  
Fransisca S Susilaningsih ◽  
Dewi MD Herawati
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Dna Methyltransferase ◽  
Google Scholar

Pengaruh lingkungan eksternal pada gen manusia akan berpengaruh pada patogenesis penyakit, dan hal ini dapat diturunkan. Studi tentang perubahan gen fenotip yang diwariskan yang tidak disebabkan oleh perubahan urutan DNA disebut epigenetik. Salah satu mekanisme epigenetik adalah metilasi DNA yang penting dalam mengatur ekspresi gen. Ulasan ini akan menjelaskan studi tentang metilasi DNA pada mukosa mulut. Metode pencarian sistematis Google Scholar dan Pubmed dilakukan untuk semua studi dalam sepuluh tahun terakhir. Hasil pencarian mendapatkan sebanyak tujuh artikel dengan ukuran sampel yang bervariasi, 16 hingga 177 sampel, sebagian besar studi kasus-kontrol padaoral premalignan lesions (OPL), oral lichenoid disease (OLD), mucositis oral pada acute lymphoblactic leukemia (ALL), dan oral squamous cell carcinoma (OSCC). Metilasi DNA pada kanker mulut menunjukkan bahwa terdapat hipermetilasi beberapa gen, walaupun status metilasi DNA dalam beberapa kasus belum menunjukkan perbedaan yang signifikan antara gen yang diperiksa. Hasil penelitian lain menunjukkan bahwa tidak ada korelasi antara metilasi DNA dan perkembangan mukositis oral pada ALL yang menerima terapi metotreksat (MTX). Mekanisme metilasi DNA pada sel malignanadalah dengan menambahkan gugus metil ke sitosin dinukleotida di CpG (cytosine phosphate guanine) pada daerah promoter oleh enzim DNA methyltransferase sehingga dapat menghambat ekspresi beberapa gen terkait pertumbuhan sel, perbaikan DNA, dan penghambat metastasis. Metilasi DNA adalah biomarker penting dalam perkembangan penyakit mukosa mulut.

Role of Clinical Palpation in Evaluation of Cervical Lymph Node in Oral Squamous Cell Carcinoma

2013 ◽  
Vol 1 (2) ◽  
pp. 02-06
Author(s):  
SM Anwar Sadat ◽  
Sufia Nasrin Rita ◽  
Shoma Banik ◽  
Md Nazmul Hasan Khandker ◽  
Md Mahfuz Hossain ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Oral Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Value ◽  
Cervical Lymph Node ◽  
Betel Quid ◽  
Cervical Lymph Nodes

A cross sectional study of 29 cases of oral squamous cell carcinoma with or without  cervical lymph node metastasis was done among Bangladeshi patients from January 2006 to December 2007. Majority of the study subjects (34.5%) belonged to the age group of 40-49 years. 58.6% of the study subjects were male, while remaining 41.4% of them were female. 51.7% of the lesions were located in the alveolar ridge where the other common sites were buccal mucosa (27.6%) and retro molar area (13.8%). Half of the study subjects (51.7%) were habituated to betel quid chewing followed by 37.9% and 10.3% were habituated to smoking and betel quid-smoking respectively. Grade I lesions was most prevalent (75.9%) in the study subjects.  Majority of cases presented with Stage IV lesions (55.2%). The sensitivity, specificity, positive predictive value, negative predictive value & accuracy of clinical palpation method for determining metastatic cervical lymph nodes were 93.33%, 64.29%, 73.68%, 90% and 79.3% respectively. Careful and repeated clinical palpation plays important role in evaluation of cervical lymph nodes though several modern techniques may help additionally in the management of oral cancer.DOI: http://dx.doi.org/10.3329/updcj.v1i2.13978 Update Dent. Coll. j. 2011: 1(2): 02-06

Management of Neck in Oral Squamous Cell Carcinoma

2011 ◽  
Vol 3 (6) ◽  
pp. 419-422
Author(s):  
Dr. Shool Rohit S Dr. Shool Rohit S ◽  
◽  
Dr. Anand P Zingade ◽  
Dr. Manish Kumar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell
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