Correction to: The Allium triquetrum L. Leaves Mitigated Hepatotoxicity and Nephrotoxicity Induced by Lead Acetate in Wistar Rats

Abstract Objectives Lead primarily affects male reproductive functions via hormonal imbalance and morphological damage to the testicular tissue with significant alteration in sperm profile and oxidative markers. Though, different studies have reported that Cocos nucifera L. oil has a wide range of biological effects, this study aimed at investigating the effect of Cocos nucifera L. oil on lead acetate-induced reproductive toxicity in male Wistar rats. Methods Twenty (20) sexually matured male Wistar rats (55–65 days) were randomly distributed into four groups (n=5). Group I (negative control)—distilled water orally for 56 days, Group II (positive control)—5 mg/kg bwt lead acetate intraperitoneally (i.p.) for 14 days, Group III—6.7 mL/kg bwt Cocos nucifera L. oil orally for 56 days and Group IV—lead acetate intraperitoneally (i.p.) for 14 days and Cocos nucifera L. oil for orally for 56 days. Rats were sacrificed by diethyl ether, after which the serum, testis and epididymis were collected and used for semen analysis, biochemical and histological analysis. Results The lead acetate significantly increases (p<0.05) testicular and epididymal malondialdehyde (MDA) levels, while a significant reduction (p<0.05) in sperm parameters, organ weight, testosterone and luteinizing hormone was observed when compared with the negative control. The coadministration of Cocos nucifera oil with lead acetate significantly increases (p<0.05) testosterone, luteinizing hormone, sperm parameters and organ weight, with a significant decrease (p<0.05) in MDA levels compared with positive control. Histological analysis showed that lead acetate distorts testicular cytoarchitecture and germ cell integrity while this was normalized in the cotreated group. Conclusions Cocos nucifera oil attenuates the deleterious effects of lead acetate in male Wistar rats, which could be attributed to its polyphenol content and antioxidant properties.

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Protective Effect of Rasayana Herbs on Lead Acetate-induced Testicular Toxicity in Wistar Rats

Indian Journal of Natural Products ◽

10.5530/ijnp.2021.1.3 ◽

2021 ◽

Vol 35 (1) ◽

pp. 9-15

Author(s):

Vikas Sharma ◽

Nagendra S Chauhan ◽

Umesh K Patil ◽

Vinod Kumar Dixit

Keyword(s):

Protective Effect ◽

Lead Acetate ◽

Wistar Rats ◽

Testicular Toxicity

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The Allium triquetrum L. Leaves Mitigated Hepatotoxicity and Nephrotoxicity Induced by Lead Acetate in Wistar Rats

Biological Trace Element Research ◽

10.1007/s12011-021-03052-y ◽

2022 ◽

Author(s):

Labiba Kahalerras ◽

Ines Otmani ◽

Cherif Abdennour

Keyword(s):

Lead Acetate ◽

Wistar Rats

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Ameliorative effect of vitamin C on the haematological changes induced by exposure of chlorpyriphos and lead acetate in Wistar rats

Comparative Clinical Pathology ◽

10.1007/s00580-013-1697-5 ◽

2013 ◽

Vol 23 (4) ◽

pp. 829-834

Author(s):

Nisar Ahmad Nisar ◽

Mudasir Sultana ◽

Naseer Ahmad Baba ◽

Parveez Ahmad Para ◽

Hina Ashraf Waiz ◽

...

Keyword(s):

Vitamin C ◽

Lead Acetate ◽

Wistar Rats ◽

Ameliorative Effect ◽

Haematological Changes

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In vivo quercetol effect in lead acetate poisoning

Analele Universitatii Ovidius Constanta - Seria Chimie ◽

10.2478/auoc-2013-0014 ◽

2013 ◽

Vol 24 (2) ◽

pp. 73-78

Author(s):

Florentina Roncea ◽

Horatiu Miresan ◽

Adrian Cosmin Rosca ◽

Mihaela Bratu ◽

Antoanela Popescu

Keyword(s):

Lead Acetate ◽

Wistar Rats ◽

Aminolevulinic Acid ◽

Statistical Significance ◽

Urine Concentration ◽

Iron Complex ◽

Spectrophotometric Assay ◽

Homogeneous Groups ◽

Number Of Individuals

Abstract The present study investigated the influence of quercetol upon δ-aminolevulinic acid (△ -ALA) urine concentration as marker of lead poisoning. The study was conducted on six lots of 6 mature Wistar rats of both sexes, lots not poisoned treated with different concentrations of quercetol (Q1, Q2), control (L6M), lot poisoned untreated (L3Pb), lots poisoned and treated with Q (L4Q1Pb and L5Q2Pb). After 11 days urine from 24 hours was collected for △-ALA spectrophotometric assay and testing the significance of mean difference of by "t" test Student at p <0.05. Statistical analysis of the data presented shows that compared to L2Q2 and L6M the amount of δ-ALA excreted in urine under quercetol influence (L4Q1Pb) shows statistical significance compared to (L2Q2) the amount of δ-ALA excreted in urine compared to (L3Pb) shows statistical significance. Different concentrations of quercetol (Q1, Q2), did not produce significant changes in the δ-ALA excreted compared with values of (L3Pb). Difference between means is probably due to sampling fluctuation, is not significant, reduced growth to eliminate δ-ALA on L4Q1Pb and L5Q2Pb is believed to be due to iron complex formation, reducing hemoglobin synthesis. From the results we conclude that hem biosynthesis does not start to grow under quercetol protection. The obtained data are not relevant statistical since interpretations were performed on non homogeneous groups in number of individuals, the percentage of mortality variability and high levels of standard deviation calculated from each lot.

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