Honey prevents neurobehavioural deficit and oxidative stress induced by lead acetate exposure in male wistar rats- a preliminary study

Purpose.This study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in a model of renal mass reduction.Methods. Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment(n=14); RMR + CAA: RMR rats treated with CAA(n=13); SO: SO rats without treatment(n=13); and SO + CAA: SO rats treated with CAA(n=13). CAA was intraperitoneally administered in a dose of 0.23 µg/Kg three times a week for six months.Results.RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity(p<0.05)and a decrease in reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. CAA administration significantly increased catalase and GR activity(p<0.05)and increased GSH/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio. No significant differences were found between the RMR groups in any of the parameters of renal function. However, CAA administration slightly improves some parameters of renal function.Conclusions.These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress.

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Ameliorative potential of Aframomum melegueta extract in cadmium-induced hepatic damage and oxidative stress in male Wistar rats

Journal of Applied Pharmaceutical Science ◽

10.7324/japs.2016.60714 ◽

2016 ◽

pp. 094-099 ◽

Cited By ~ 8

Author(s):

Babatunji Oyinloye ◽

Basiru Ajiboye ◽

Oluwafemi Ojo ◽

Habiba Musa ◽

Sunday Onikanni ◽

...

Keyword(s):

Oxidative Stress ◽

Wistar Rats ◽

Hepatic Damage ◽

Male Wistar Rats ◽

And Oxidative Stress

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Sex hormones and oxidative stress biomarkers of male Wistar rats treated with Moringa oleifera seed fractions

JBRA Assisted Reproduction ◽

10.5935/1518-0557.20190047 ◽

2019 ◽

Author(s):

Olawale Olaleye Obembe

Keyword(s):

Oxidative Stress ◽

Sex Hormones ◽

Wistar Rats ◽

Moringa Oleifera ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Male Wistar Rats ◽

And Oxidative Stress ◽

Moringa Oleifera Seed

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Effects of Aqueous Leaf Extract of Simarouba glauca DC (Simaroubaceae) on Lipoprotein Homeostasis and Oxidative Stress Biomarkers

Pharmacology and Toxicology of Natural Medicines (ISSN: 2756-6838) ◽

10.52406/ptnm.v1i1.12 ◽

2021 ◽

Vol 1 (1) ◽

pp. 20-29

Author(s):

Sammydavies E. Osagie-Eweka ◽

Noghayin J. Orhue ◽

Eric I. Omogbai

Keyword(s):

Oxidative Stress ◽

Wistar Rats ◽

Leaf Extract ◽

Biologically Active ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Male Wistar Rats ◽

Aqueous Leaf Extract ◽

Simarouba Glauca ◽

And Oxidative Stress

Background and Purpose: Simarouba glauca is widely reported to contain a number of biologically active compounds with potentials in the treatment of numerous diseases. The study was conducted to evaluate the sub-acute effects of the aqueous leaf extract of Simarouba glauca (AESG) on lipoproteins and oxidative stress biomarkers in male Wistar rats. Methods: Oral administration of AESG was carried out in line with the guidelines of the Organization for Economic Co-operation and Development (OECD), No. 425 using a total of 24 male Wistar rats allotted to four groups (n=6); given distilled water, 500, 1000, and 2000 mg/kg/day of AESG respectively for 30 days. Results: In plasma, there was a significant reduction (P?0.05) in HDL-cholesterol; elevated (P?0.05) triglycerides (TG) at 1000 and 2000 mg/kg/day; elevated (P?0.05), and LDL-cholesterol at 500 and 1000 mg/kg/day, relative to the control. While the level of liver total cholesterol (TC) reduced significantly, it increased in the heart. Catalase (CAT) activity in the liver increased significantly (P?0.05) at all doses. The dose of 1000 mg/kg/day significantly (P?0.05) elevated kidney CAT activity. The activities of superoxide dismutase (SOD) in liver and heart reduced (P?0.05) at 500 mg/kg/day. At all doses, the levels of reduced glutathione (GSH) in plasma, liver and heart were comparable with the control. Although, there were no significant changes in plasma and liver glutathione peroxidase (GSH-PX) activity at all doses, animals given 500 mg/kg had reduction (P?0.05) in the heart GSH-PX activity compared to the control. Conclusion: Oral sub-acute AESG at high doses altered lipid homeostasis in plasma and heart without lipid peroxidation or oxidative stress. The extract has the potential to cause hyperlipidemia.

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Ameliorative Effect of Trevo Dietary Supplement Against Lead Acetate Nephrotoxicity

Iranian Jornal of Toxicology ◽

10.32598/ijt.16.1.857.1 ◽

2022 ◽

Vol 16 (1) ◽

pp. 34-42

Author(s):

Omotayo B. Ilesanmi ◽

◽

Eni-yimini Solomon Agoro ◽

Keyword(s):

Oxidative Stress ◽

Uric Acid ◽

Lead Acetate ◽

Wistar Rats ◽

Antioxidant Properties ◽

Kidney Tissue ◽

Lead Toxicity ◽

Serum Levels ◽

Tissue Samples ◽

Male Wistar Rats

Background: Trevo is a nutritional supplement with numerous bioactive natural products, with detoxifying and antioxidant properties. The purpose of this study was to investigate the ability of Trévo to protect against oxidative stress induced by lead in the kidneys of male Wistar rats. Methods: Thirty-five healthy male Wistar rats were divided into five groups of seven rats each, using a randomized design. I=control; II=15 mg/kg of lead acetate (PbA); III=2 ml/kg of trevo+PbA; IV=5 ml/kg of trevo+PbA; V=5 ml/kg of trevo. Animals were treated with trevo for five days before co-administration with lead intraperitoneally for 10 consecutive days. Animals were sacrificed 24hr after the last administration, blood samples were collected via cardiac puncture, and processed for assessment of urea, creatinine, and uric acid (UA), while the kidney samples were excised and processed for the following biochemical assays: Malondialdehyde (MDA), Glutathione-S-Transferase (GST), Catalase (CAT), Superoxide Dismutase (SOD), and Reduced Glutathione (GSH). Results: Injection of PbA caused a significant increase in the serum levels of urea, creatinine, and uric acid, and a significant increase (P<0.001) in the MDA concentration, and decreases in GSH concentration, CAT, SOD, and GST activities (P<0.05) as compared to the controls. Pretreatment with trevo prevented the oxidative stress induced by lead acetate in the kidney tissue samples and improve the renal function. The protective effect was evident at 5 ml/kg of trevo. Conclusion: The results showed that trevo was nephroprotective against lead toxicity and the activity might be linked to the presence of numerous antioxidant phytochemicals present in trevo.

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