Delaying time to first nocturnal void may have beneficial effects on reducing blood glucose levels

It was long thought that the only hormone capable of reversing the catabolic consequences of diabetes was insulin. However, various studies have demonstrated that the adipocyte-derived hormone leptin can robustly lower blood glucose levels in rodent models of insulin-deficient diabetes. In addition, it has been suggested that some of the metabolic manifestations of insulin-deficient diabetes are due to hypoleptinemia as opposed to hypoinsulinemia. Because insulin therapy increases leptin levels, we sought to investigate the contribution of leptin to the beneficial effects of insulin therapy. To do this, we tested insulin therapy in streptozotocin (STZ) diabetic mice that were either on an ob/ ob background or that were given a leptin antagonist to determine if blocking leptin action would blunt the glucose-lowering effects of insulin therapy. We found that STZ diabetic ob/ ob mice have a diminished blood glucose-lowering effect in response to insulin therapy compared with STZ diabetic controls and exhibited more severe weight loss post-STZ injection. In addition, STZ diabetic mice administered a leptin antagonist through daily injection or plasmid expression respond less robustly to insulin therapy as assessed by both fasting blood glucose levels and blood glucose levels during an oral glucose tolerance test. However, leptin antagonism did not prevent the insulin-induced reduction in β-hydroxybutyrate and triglyceride levels. Therefore, we conclude that elevated leptin levels can contribute to the glucose-lowering effect of insulin therapy in insulin-deficient diabetes.

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Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy

Journal of Diabetes Research ◽

10.1155/2016/1786789 ◽

2016 ◽

Vol 2016 ◽

pp. 1-10 ◽

Cited By ~ 3

Author(s):

Tarek Kamal Abouzed ◽

Seiichi Munesue ◽

Ai Harashima ◽

Yusuke Masuo ◽

Yukio Kato ◽

...

Keyword(s):

Diabetic Nephropathy ◽

Blood Glucose ◽

Macrophage Infiltration ◽

Gene Expressions ◽

Beneficial Effects ◽

Glucose Levels ◽

Developmental Factors ◽

Blood Glucose Levels ◽

Patients With Diabetes ◽

Long Acting

Objective. Diabetic nephropathy is a life-threatening complication in patients with long-standing diabetes. Hemodynamic, inflammatory, and metabolic factors are considered as developmental factors for diabetic nephropathy. In this study, we evaluated whether pharmacological interventions with salicylate, compared to pyridoxamine, could prevent diabetic nephropathy in mice. Methods. Male mice overexpressing inducible nitric oxide synthase in pancreatic β-cells were employed as a diabetic model. Salicylate (3 g/kg diet) or pyridoxamine (1 g/L drinking water; ~200 mg/kg/day) was given for 16 weeks to assess the development of diabetic nephropathy. Treatment with long-acting insulin (Levemir 2 units/kg twice a day) was used as a control. Results. Although higher blood glucose levels were not significantly affected by pyridoxamine, early to late stage indices of nephropathy were attenuated, including kidney enlargement, albuminuria, and increased serum creatinine, glomerulosclerosis, and inflammatory and profibrotic gene expressions. Salicylate showed beneficial effects on diabetic nephropathy similar to those of pyridoxamine, which include lowering blood glucose levels and inhibiting macrophage infiltration into the kidneys. Attenuation of macrophage infiltration into the kidneys and upregulation of antiglycating enzyme glyoxalase 1 gene expression were found only in the salicylate treatment group. Conclusions. Treatment with salicylate and pyridoxamine could prevent the development of diabetic nephropathy in mice and, therefore, would be a potentially useful therapeutic strategy against kidney problems in patients with diabetes.

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The Beneficial Effects of SesaVitaTM on Lipid Profiles and Blood Glucose Levels in Subjects With Prediabetes and Mild-To-Moderate Hyperlipidemia in India

Journal of Food Research ◽

10.5539/jfr.v2n5p104 ◽

2013 ◽

Vol 2 (5) ◽

pp. 104 ◽

Cited By ~ 1

Author(s):

H. N. Shivaprasad ◽

M. Bhanumathy ◽

Ceyhun Tamer ◽

G. Sushma ◽

K. R. Raveendra ◽

...

Keyword(s):

Blood Glucose ◽

Lipid Profile ◽

Lifestyle Changes ◽

Secondary Outcome ◽

Oral Glucose ◽

Double Blind Study ◽

Beneficial Effects ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Normal Ranges

Individuals suffering from Type 2 diabetes develop prediabetes before progression of diabetes. In case of prediabetes people, the blood glucose levels are higher than normal but not sufficient to be diagnosed as diabetes. On the basis of existing reports on Sesame extract, SesaVitaTM which is an herbal food supplement containing Sesame seeds (Sesamum indicum L.) extract may provide an option for management of prediabetes. The objective of this study was to determine the beneficial effects of SesaVitaTM in prediabetes and mild to moderate hyperlipidemia subjects. This randomized, placebo-controlled, double-blind study comprised of 13 female and 07 male patients with prediabetes and mild to moderate hyperlipidemia, aged between 18 and 65 years. Twenty subjects were randomized to receive SesaVitaTM (500 mg/day) or placebo along with therapeutic lifestyle changes for 6 weeks. The primary outcome was the measure of efficacy in terms of change in serum lipid profile and glycaemic levels on week 3 and 6. Secondary outcome measures include safety and tolerability evaluated by physical examination and clinical laboratory evaluations. Improvements in lipid profile and glycaemic levels were observed in SesaVitaTM treated group when compared with placebo and baseline. A statistical significant reduction was observed in low density lipoprotein cholesterol (LDL-C), total cholesterol (TC), oral glucose tolerance test (OGTT) and fasting blood sugar (FBS) levels during week 3 and 6 when treated with SesaVitaTM extract. No adverse events occurred and all safety parameters were within normal ranges during the study. This study revealed that the treatment with SesaVitaTM was safe and well tolerated; may be beneficial in the management of prediabetes and mild-to-moderate hyperlipidemia.

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Beneficial effects of antioxidant property of Aegle marmelos leaves serum antioxidant status on blood glucose levels in diabetes type 2 subjects

Endocrine Abstracts ◽

10.1530/endoabs.37.ep462 ◽

2015 ◽

Author(s):

Vinita Nigam ◽

Vanisha Nambiar

Keyword(s):

Blood Glucose ◽

Antioxidant Status ◽

Diabetes Type 2 ◽

Antioxidant Property ◽

Diabetes Type ◽

Aegle Marmelos ◽

Beneficial Effects ◽

Glucose Levels ◽

Blood Glucose Levels

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Ginseng for the treatment of diabetes and diabetes-related cardiovascular complications: a discussion of the evidence

Canadian Journal of Physiology and Pharmacology ◽

10.1139/cjpp-2018-0440 ◽

2019 ◽

Vol 97 (4) ◽

pp. 265-276 ◽

Cited By ~ 2

Author(s):

Morris Karmazyn ◽

Xiaohong Tracey Gan

Keyword(s):

Blood Glucose ◽

Treatment Options ◽

Cardiovascular Complications ◽

Traditional Medicines ◽

Beneficial Effects ◽

Glucose Levels ◽

Production Type ◽

Blood Glucose Levels ◽

Treatment Of Diabetes ◽

Type 1 Dm

Diabetes mellitus (DM) is a chronic metabolic disorder associated with elevated blood glucose levels due either to insufficient insulin production (type 1 DM) or to insulin resistance (type 2 DM). The incidence of DM around the world continues to rise dramatically with more than 400 million cases reported today. Among the most serious consequences of chronic DM are cardiovascular complications that can have deleterious effects. Although numerous treatment options are available, including both pharmacological and nonpharmacological, there is substantial emerging interest in the use of traditional medicines for the treatment of this condition and its complications. Among these is ginseng, a medicinal herb that belongs to the genus Panax and has been used for thousands of years as a medicinal agent especially in Asian cultures. There is emerging evidence from both animal and clinical studies that ginseng, ginseng constituents including ginsenosides, and ginseng-containing formulations can produce beneficial effects in terms of normalization of blood glucose levels and attenuation of cardiovascular complications through a multiplicity of mechanisms. Although more research is required, ginseng may offer a useful therapy for the treatment of diabetes as well as its complications.

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Antidiabetic effect of Ruta montana L. in streptozotocin-induced diabetic rats

Journal of Basic and Clinical Physiology and Pharmacology ◽

10.1515/jbcpp-2016-0030 ◽

2017 ◽

Vol 28 (3) ◽

Cited By ~ 7

Author(s):

Omar Farid ◽

Morad Hebi ◽

Mohammed Ajebli ◽

Ahmed EL Hidani ◽

Mohamed Eddouks

Keyword(s):

Blood Glucose ◽

Diabetes Management ◽

Tolerance Test ◽

Diabetic Rats ◽

Diabetic Rat ◽

Oral Glucose ◽

Antidiabetic Effect ◽

Beneficial Effects ◽

Glucose Levels ◽

Blood Glucose Levels

AbstractBackground:(L.) is known as a medicinal plant with many beneficial effects, including those that can be used in the treatment of diabetes. The objective of the study was to investigate the antidiabetic effect of this plant in diabetic rat.Methods:This study investigated the effects of an aerial part aqueous extract (APAE) ofResults:Both single and repeated oral doses of APAE (5 mg/kg) produced significant reductions in the blood glucose levels in normal and STZ-induced rats. Oral glucose tolerance test results showed that, after the administration of 3 g/kg of glucose, RM APAE (5 mg/kg) improved the increase in blood glucose levels in normal rats at the 30th min (p<0.01) and 90th min (p<0.001).Conclusions:RM APAE exhibits a potent hypoglycemic effect in normal rats and an antidiabetic effect in STZ-induced rats. This finding supports the use of this plant in traditional Moroccan medicine for diabetes management.

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