scholarly journals Expression Profiling of Notch Signalling Pathway and Gamma-Secretase Activity in the Brain of Ts1Cje Mouse Model of Down Syndrome

2019 ◽  
Vol 67 (4) ◽  
pp. 632-642
Author(s):  
Hadri Hadi Yusof ◽  
Han-Chung Lee ◽  
Eryse Amira Seth ◽  
Xiangzhong Wu ◽  
Chelsee A. Hewitt ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Expression Profiling ◽  
Notch Signalling ◽  
Signalling Pathway ◽  
Gamma Secretase ◽  
Notch Signalling Pathway ◽  
Secretase Activity ◽  
The Brain

scholarly journals The role of Notch ligand, Delta-like ligand 4 (DLL4), in cancer angiogenesis—implications for therapy

2021 ◽  
Author(s):  
Marlena Brzozowa-Zasada
Keyword(s):  
Cancer Therapy ◽  
Notch Signalling ◽  
Signalling Pathway ◽  
Gamma Secretase ◽  
Tumour Angiogenesis ◽  
Notch Signalling Pathway ◽  
Expression Levels ◽  
Blocking Agents ◽  
Anti Cancer

Summary Background It is generally accepted that angiogenesis is a complex and tightly regulated process characterized by the growth of blood vessels from existing vasculature. Activation of the Notch signalling pathway affects multiple aspects of vascular development. One of the components of the Notch signalling pathway, Delta-like ligand 4 (DLL4), has recently appeared as a critical regulator of tumour angiogenesis and thus as a promising therapeutic target. Methods This review article includes available data from peer-reviewed publications associated with the role of DLL4 in cancer angiogenesis. Searches were performed in PubMed, EMBASE, Google Scholar and Web of Science using the terms “tumour angiogenesis”, “DLL4”, “Notch signalling” and “anti-cancer therapy”. Results The survival curves of cancer patients revealed that the patients with high DLL4 expression levels had significantly shorter survival times than the patients with low DLL4 expression. Moreover, a positive correlation was also identified between DLL4 and VEGF receptorsʼ expression levels. It seems that inhibition of DLL4 may exert potent growth inhibitory effects on some tumours resistant to anti-VEGF therapies. A great number of blocking agents of DLL4/Notch signalling including anti-DLL4 antibodies, DNA vaccination, Notch antibodies and gamma-secretase inhibitors have been studied in preclinical tumour models. Conclusion DLL4 seems to be a promising target in anti-cancer therapy. Nevertheless, the careful evaluation of adverse effects on normal physiological processes in relation to therapeutic doses of anti-DLL4 drugs will be significant for advancement of DLL4 blocking agents in clinical oncology.

scholarly journals The role of JAK-STAT signalling pathway promotes neurogenic-to-gliogenic shift in the brain of Ts1cje mouse model for Down syndrome

2016 ◽  
Vol 10 ◽  
Author(s):  
Lee Han-Chung ◽  
Nordin Norshariza ◽  
Vidyadaran Sharmili ◽  
Cheah Pike-See ◽  
Ling King-Hwa
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Signalling Pathway ◽  
The Brain

scholarly journals Disrupted interferon-related molecular networks and the over-expressed Ifnar1 in the brain of adult Ts1Cje mouse model of Down syndrome

2016 ◽  
Vol 10 ◽  
Author(s):  
Tan Kai-Leng ◽  
Lee Han-Chung ◽  
Ling King-Hwa ◽  
Scott Hamish. S. ◽  
Lai Mei-I ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Molecular Networks ◽  
The Brain

scholarly journals Novel players in the Notch signalling pathway

2007 ◽  
Vol 306 (1) ◽  
pp. 301
Author(s):  
Hugo J. Bellen ◽  
Melih Acar ◽  
Hamed Jafar Nejad ◽  
Anchi Tien ◽  
Akhila Rajan
Keyword(s):  
Notch Signalling ◽  
Signalling Pathway ◽  
Notch Signalling Pathway

Conservation of the Notch signalling pathway in mammalian neurogenesis

Development ◽  
1997 ◽  
Vol 124 (6) ◽  
pp. 1139-1148 ◽  
Author(s):  
J.L. Pompa de la ◽  
A. Wakeham ◽  
K.M. Correia ◽  
E. Samper ◽  
S. Brown ◽  
...  
Keyword(s):  
Cell Fate ◽  
Notch Pathway ◽  
Stem Cell Differentiation ◽  
Notch Signalling ◽  
Signalling Pathway ◽  
Notch Signalling Pathway ◽  
Altered Expression ◽  
Cell Fate Decisions ◽  
Targeted Mutation ◽  
Multiple Cell

The Notch pathway functions in multiple cell fate determination processes in invertebrate embryos, including the decision between the neuroblast and epidermoblast lineages in Drosophila. In the mouse, targeted mutation of the Notch pathway genes Notch1 and RBP-Jk has demonstrated a role for these genes in somite segmentation, but a function in neurogenesis and in cell fate decisions has not been shown. Here we show that these mutations lead to altered expression of the Notch signalling pathway homologues Hes-5, Mash-1 and Dll1, resulting in enhanced neurogenesis. Precocious neuronal differentiation is indicated by the expanded expression domains of Math4A, neuroD and NSCL-1. The RBP-Jk mutation has stronger effects on expression of these genes than does the Notch1 mutation, consistent with functional redundancy of Notch genes in neurogenesis. Our results demonstrate conservation of the Notch pathway and its regulatory mechanisms from fly to mouse, and support a role for the murine Notch signalling pathway in the regulation of neural stem cell differentiation.

Matrine promotes hepatic oval cells differentiation into hepatocytes and alleviates liver injury by suppression of Notch signalling pathway

Life Sciences ◽  
2020 ◽  
Vol 261 ◽  
pp. 118354
Author(s):  
Jianfei Shi ◽  
Guangjie Han ◽  
Jinfeng Wang ◽  
Xin Han ◽  
Man Zhao ◽  
...  
Keyword(s):  
Liver Injury ◽  
Notch Signalling ◽  
Signalling Pathway ◽  
Oval Cells ◽  
Notch Signalling Pathway ◽  
Hepatic Oval Cells

The Notch Signalling Pathway in the Development of the Mouse Placenta

Placenta ◽  
2008 ◽  
Vol 29 (8) ◽  
pp. 651-659 ◽  
Author(s):  
M. Gasperowicz ◽  
F. Otto
Keyword(s):  
Notch Signalling ◽  
Signalling Pathway ◽  
Notch Signalling Pathway ◽  
Mouse Placenta

Gene and protein expression profiles of JAK-STAT signalling pathway in the developing brain of the Ts1Cje down syndrome mouse model

2019 ◽  
Vol 129 (9) ◽  
pp. 871-881 ◽  
Author(s):  
Han-Chung Lee ◽  
Hadri Hadi Md Yusof ◽  
Melody Pui-Yee Leong ◽  
Shahidee Zainal Abidin ◽  
Eryse Amira Seth ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Protein Expression ◽  
Expression Profiles ◽  
Developing Brain ◽  
Signalling Pathway ◽  
Gene And Protein Expression ◽  
Protein Expression Profiles
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